protein coding gene - cdc13 (SPBC582.03) - G2/M B-type cyclin Cdc13

Gene summary

Standard name

cdc13

Systematic ID

SPBC582.03

Product

G2/M B-type cyclin Cdc13

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

P10815

ORFeome ID

23/23D02

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome II: 420111..423276 forward strand

Annotation

Protein features

Orthologs

• CCNB1 (HGNC:1579) Homo sapiens
• CCNB2 (HGNC:1580) Homo sapiens
• CCNB3 (HGNC:18709) Homo sapiens
• cdc13 (SJAG_04140) Schizosaccharomyces japonicus
• CLB1 (YGR108W) Saccharomyces cerevisiae
• CLB2 (YPR119W) Saccharomyces cerevisiae

References / Literature

PMID:20739936 - Phosphorylation of the CPC by Cdk1 promotes chromosome bi-orientation.

Tsukahara T et al. Nature 2010 Oct 07;467(7316):719-23

PMID:8413179 - Genetic analysis of human p34CDC2 function in fission yeast.

MacNeill SA et al. Mol Gen Genet 1993 Sep;240(3):315-22

PMID:19366728 - Genetic control of cellular quiescence in S. pombe.

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PMID:15923565 - Multiple reaction monitoring to identify sites of protein phosphorylation with high sensitivity.

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PMID:26670050 - Regulation of mRNA Levels by Decay-Promoting Introns that Recruit the Exosome Specificity Factor Mmi1.

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PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

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PMID:1828291 - Identification of a G1-type cyclin puc1+ in the fission yeast Schizosaccharomyces pombe.

Forsburg SL et al. Nature 1991 May 16;351(6323):245-8

PMID:1655416 - Phosphorylation at Thr167 is required for Schizosaccharomyces pombe p34cdc2 function.

Gould KL et al. EMBO J 1991 Nov;10(11):3297-309

PMID:2004705 - Genetic and molecular analysis of cdr1/nim1 in Schizosaccharomyces pombe.

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PMID:7909513 - A B-type cyclin negatively regulates conjugation via interacting with cell cycle 'start' genes in fission yeast.

Obara-Ishihara T et al. EMBO J 1994 Apr 15;13(8):1863-72

PMID:17531813 - Cdc18 enforces long-term maintenance of the S phase checkpoint by anchoring the Rad3-Rad26 complex to chromatin.

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PMID:8657126 - Cig2, a B-type cyclin, promotes the onset of S in Schizosaccharomyces pombe.

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PMID:9303312 - Control of S-phase periodic transcription in the fission yeast mitotic cycle.

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PMID:9571240 - Fission yeast Ste9, a homolog of Hct1/Cdh1 and Fizzy-related, is a novel negative regulator of cell cycle progression during G1-phase.

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PMID:15347659 - DNA replication checkpoint control mediated by the spindle checkpoint protein Mad2p in fission yeast.

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PMID:18059475 - Cdc2p controls the forkhead transcription factor Fkh2p by phosphorylation during sexual differentiation in fission yeast.

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PMID:16390871 - Activity of Cdc2 and its interaction with the cyclin Cdc13 depend on the molecular chaperone Cdc37 in Schizosaccharomyces pombe.

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PMID:23695164 - Cross-species protein interactome mapping reveals species-specific wiring of stress response pathways.

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PMID:8087848 - Temporal order of S phase and mitosis in fission yeast is determined by the state of the p34cdc2-mitotic B cyclin complex.

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PMID:19592249 - A novel protein phosphatase 1-dependent spindle checkpoint silencing mechanism.

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PMID:24074952 - Phosphorylation-dependent assembly and coordination of the DNA damage checkpoint apparatus by Rad4(TopBP1).

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PMID:9303310 - p25rum1 promotes proteolysis of the mitotic B-cyclin p56cdc13 during G1 of the fission yeast cell cycle.

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PMID:16079915 - The DASH complex and Klp5/Klp6 kinesin coordinate bipolar chromosome attachment in fission yeast.

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PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.

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PMID:21540296 - Condensin phosphorylated by the Aurora-B-like kinase Ark1 is continuously required until telophase in a mode distinct from Top2.

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PMID:23442800 - An E2 enzyme Ubc11 is required for ubiquitination of Slp1/Cdc20 and spindle checkpoint silencing in fission yeast.

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PMID:12419251 - Stable association of mitotic cyclin B/Cdc2 to replication origins prevents endoreduplication.

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PMID:14985109 - Cdk inhibitor ste9p/srw1p is involved in response to protein synthesis inhibition in fission yeast.

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PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

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PMID:35811551 - Mitotic checkpoint gene expression is tuned by codon usage bias.

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PMID:37463585 - The fission yeast cell size control system integrates pathways measuring cell surface area, volume, and time.

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PMID:9552380 - Regulation of G1 progression in fission yeast by the rum1+ gene product.

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PMID:11937031 - CDK phosphorylation of Drc1 regulates DNA replication in fission yeast.

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PMID:9398669 - A WD repeat protein controls the cell cycle and differentiation by negatively regulating Cdc2/B-type cyclin complexes.

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PMID:8521500 - p25rum1 orders S phase and mitosis by acting as an inhibitor of the p34cdc2 mitotic kinase.

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PMID:12724408 - Two ubiquitin-conjugating enzymes, UbcP1/Ubc4 and UbcP4/Ubc11, have distinct functions for ubiquitination of mitotic cyclin.

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PMID:24583014 - Slow checkpoint activation kinetics as a safety device in anaphase.

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PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

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PMID:12093738 - G(1)/S CDK is inhibited to restrain mitotic onset when DNA replication is blocked in fission yeast.

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PMID:26131711 - Two Distinct Cdc2 Pools Regulate Cell Cycle Progression and the DNA Damage Response in the Fission Yeast S.pombe.

Caspari T et al. PLoS One 2015;10(7):e0130748

PMID:2847913 - Involvement of cdc13+ in mitotic control in Schizosaccharomyces pombe: possible interaction of the gene product with microtubules.

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PMID:1533272 - A dominant negative allele of p34cdc2 shows altered phosphoamino acid content and sequesters p56cdc13 cyclin.

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PMID:25891897 - A single cyclin-CDK complex is sufficient for both mitotic and meiotic progression in fission yeast.

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PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

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PMID:7957098 - Fission yeast cut5 links nuclear chromatin and M phase regulator in the replication checkpoint control.

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PMID:29466359 - CDK activity provides temporal and quantitative cues for organizing genome duplication.

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PMID:11486016 - Control of DNA rereplication via Cdc2 phosphorylation sites in the origin recognition complex.

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PMID:11084332 - Cut8, essential for anaphase, controls localization of 26S proteasome, facilitating destruction of cyclin and Cut2.

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PMID:22119525 - SIN-inhibitory phosphatase complex promotes Cdc11p dephosphorylation and propagates SIN asymmetry in fission yeast.

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PMID:11533255 - Study of cyclin proteolysis in anaphase-promoting complex (APC) mutant cells reveals the requirement for APC function in the final steps of the fission yeast septation initiation network.

Chang L et al. Mol Cell Biol 2001 Oct;21(19):6681-94

PMID:19696784 - Nucleocytoplasmic transport of Alp7/TACC organizes spatiotemporal microtubule formation in fission yeast.

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PMID:22084378 - Nutrient limitations alter cell division control and chromosome segregation through growth-related kinases and phosphatases.

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PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

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PMID:27618268 - Bub3-Bub1 Binding to Spc7/KNL1 Toggles the Spindle Checkpoint Switch by Licensing the Interaction of Bub1 with Mad1-Mad2.

Mora-Santos MD et al. Curr Biol 2016 Oct 10;26(19):2642-2650

PMID:2320127 - Regulation of mitosis by cyclic accumulation of p80cdc25 mitotic inducer in fission yeast.

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PMID:19487461 - Cyclin-dependent kinase inhibits reinitiation of a normal S-phase program during G2 in fission yeast.

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PMID:28178520 - Identification of a Sgo2-Dependent but Mad2-Independent Pathway Controlling Anaphase Onset in Fission Yeast.

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PMID:18303049 - Chemical genetic analysis of the regulatory role of Cdc2p in the S. pombe septation initiation network.

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PMID:10581266 - The identification of Wos2, a p23 homologue that interacts with Wee1 and Cdc2 in the mitotic control of fission yeasts.

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PMID:29046339 - A checkpoint-independent mechanism delays entry into mitosis after UV irradiation.

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PMID:15466421 - A screen for Schizosaccharomyces pombe mutants defective in rereplication identifies new alleles of rad4+, cut9+ and psf2+.

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PMID:33176152 - Acute Heat Stress Leads to Reversible Aggregation of Nuclear Proteins into Nucleolar Rings in Fission Yeast.

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PMID:33419777 - Identification of mutants with increased variation in cell size at onset of mitosis in fission yeast.

Scotchman E et al. J Cell Sci 2021 Feb 11;134(3)

PMID:7796804 - A pre-start checkpoint preventing mitosis in fission yeast acts independently of p34cdc2 tyrosine phosphorylation.

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PMID:8437586 - Mutational analysis of the fission yeast p34cdc2 protein kinase gene.

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PMID:1934126 - Common genes and pathways in the regulation of the mitotic and meiotic cell cycles of Schizosaccharomyces pombe.

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PMID:10921878 - Fission yeast Fizzy-related protein srw1p is a G(1)-specific promoter of mitotic cyclin B degradation.

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PMID:11493649 - Fission yeast mfr1 activates APC and coordinates meiotic nuclear division with sporulation.

Blanco MA et al. J Cell Sci 2001 Jun;114(Pt 11):2135-43

PMID:2245912 - stf1: non-wee mutations epistatic to cdc25 in the fission yeast Schizosaccharomyces pombe.

Hudson JD et al. Genetics 1990 Oct;126(2):309-15

PMID:8631306 - A single fission yeast mitotic cyclin B p34cdc2 kinase promotes both S-phase and mitosis in the absence of G1 cyclins.

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PMID:17178839 - Fission yeast Cut8 is required for the repair of DNA double-strand breaks, ribosomal DNA maintenance, and cell survival in the absence of Rqh1 helicase.

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PMID:8918880 - 20S cyclosome complex formation and proteolytic activity inhibited by the cAMP/PKA pathway.

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PMID:9034336 - Fission yeast pheromone blocks S-phase by inhibiting the G1 cyclin B-p34cdc2 kinase.

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PMID:9436991 - Negative regulation of Cdc18 DNA replication protein by Cdc2.

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PMID:16049013 - Regulation of Cdc2p and Cdc13p is required for cell cycle arrest induced by defective RNA splicing in fission yeast.

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PMID:8887552 - A novel S phase inhibitor in fission yeast.

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PMID:9614176 - Cyclin B proteolysis and the cyclin-dependent kinase inhibitor rum1p are required for pheromone-induced G1 arrest in fission yeast.

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PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.

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PMID:11683390 - In vivo localisation of fission yeast cyclin-dependent kinase cdc2p and cyclin B cdc13p during mitosis and meiosis.

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PMID:37128864 - CDK actively contributes to establishment of the stationary phase state in fission yeast.

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PMID:2569363 - The fission yeast cdc2/cdc13/suc1 protein kinase: regulation of catalytic activity and nuclear localization.

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PMID:10725227 - A fission yeast general translation factor reveals links between protein synthesis and cell cycle controls.

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PMID:24506453 - The RNA-binding protein Spo5 promotes meiosis II by regulating cyclin Cdc13 in fission yeast.

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PMID:10947840 - Mis3 with a conserved RNA binding motif is essential for ribosome biogenesis and implicated in the start of cell growth and S phase checkpoint.

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PMID:2474475 - cdc2 and the regulation of mitosis: six interacting mcs genes.

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PMID:26527280 - Robust Ordering of Anaphase Events by Adaptive Thresholds and Competing Degradation Pathways.

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PMID:9755169 - Cdc18 transcription and proteolysis couple S phase to passage through mitosis.

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PMID:9632761 - Tyrosine phosphorylation of cdc2 is required for the replication checkpoint in Schizosaccharomyces pombe.

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PMID:2908246 - Cloning and sequencing of the cyclin-related cdc13+ gene and a cytological study of its role in fission yeast mitosis.

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PMID:21511999 - Comparative functional genomics of the fission yeasts.

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PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.

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PMID:19686686 - Phospho-regulated interaction between kinesin-6 Klp9p and microtubule bundler Ase1p promotes spindle elongation.

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PMID:11777938 - Polo boxes and Cut23 (Apc8) mediate an interaction between polo kinase and the anaphase-promoting complex for fission yeast mitosis.

May KM et al. J Cell Biol 2002 Jan 07;156(1):23-8

PMID:1699136 - Distinct nuclear and spindle pole body population of cyclin-cdc2 in fission yeast.

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PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.

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PMID:12023299 - Cdc2-cyclin B kinase activity links Crb2 and Rqh1-topoisomerase III.

Caspari T et al. Genes Dev 2002 May 15;16(10):1195-208

PMID:11460168 - A MAP kinase-dependent actin checkpoint ensures proper spindle orientation in fission yeast.

Gachet Y et al. Nature 2001 Jul 19;412(6844):352-5

PMID:20133687 - Synergistic roles of the proteasome and autophagy for mitochondrial maintenance and chronological lifespan in fission yeast.

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PMID:21389117 - Mes1 controls the meiosis I to meiosis II transition by distinctly regulating the anaphase-promoting complex/cyclosome coactivators Fzr1/Mfr1 and Slp1 in fission yeast.

Kimata Y et al. Mol Biol Cell 2011 May;22(9):1486-94

PMID:27736299 - A genome-wide screen to identify genes controlling the rate of entry into mitosis in fission yeast.

Moris N et al. Cell Cycle 2016 Nov 16;15(22):3121-3130

PMID:29813053 - Specific detection of fission yeast primary septum reveals septum and cleavage furrow ingression during early anaphase independent of mitosis completion.

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PMID:30640914 - CDK contribution to DSB formation and recombination in fission yeast meiosis.

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PMID:6943408 - Cell division cycle mutants altered in DNA replication and mitosis in the fission yeast Schizosaccharomyces pombe.

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PMID:8895572 - The role of proteolysis in cell cycle progression in Schizosaccharomyces pombe.

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PMID:9353247 - Regulation of the replication initiator protein p65cdc18 by CDK phosphorylation.

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PMID:12618370 - Schizosaccharomyces pombe essential genes: a pilot study.

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PMID:9739083 - Cdc18p can block mitosis by two independent mechanisms.

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PMID:18331722 - A mutual inhibition between APC/C and its substrate Mes1 required for meiotic progression in fission yeast.

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PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:9843577 - The cdr2(+) gene encodes a regulator of G2/M progression and cytokinesis in Schizosaccharomyces pombe.

Breeding CS et al. Mol Biol Cell 1998 Dec;9(12):3399-415

PMID:10388806 - Rereplication phenomenon in fission yeast requires MCM proteins and other S phase genes.

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PMID:28103117 - Wee1 and Cdc25 are controlled by conserved PP2A-dependent mechanisms in fission yeast.

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PMID:11711540 - The Ded1 DEAD box helicase interacts with Chk1 and Cdc2.

Liu HY et al. J Biol Chem 2002 Jan 25;277(4):2637-43

PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.

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PMID:9154838 - A ubiquitin-conjugating enzyme in fission yeast that is essential for the onset of anaphase in mitosis.

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PMID:22768388 - Translational control of cell division by Elongator.

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PMID:36108046 - Recovery from spindle checkpoint-mediated arrest requires a novel Dnt1-dependent APC/C activation mechanism.

Bai S et al. PLoS Genet 2022 Sep;18(9):e1010397

PMID:6828164 - Control of timing of cell cycle events in fission yeast by the wee 1+ gene.

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PMID:15911625 - Functional homology among human and fission yeast Cdc14 phosphatases.

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PMID:23628763 - Cuf2 boosts the transcription of APC/C activator Fzr1 to terminate the meiotic division cycle.

Aoi Y et al. EMBO Rep 2013 Jun;14(6):553-60

PMID:9430640 - Regulation of the G1 phase of the cell cycle by periodic stabilization and degradation of the p25rum1 CDK inhibitor.

Benito J et al. EMBO J 1998 Jan 15;17(2):482-97

PMID:7593289 - Interaction of cdc2 and rum1 regulates Start and S-phase in fission yeast.

Labib K et al. J Cell Sci 1995 Oct;108 ( Pt 10):3285-94

PMID:15483052 - BAF53/Arp4 homolog Alp5 in fission yeast is required for histone H4 acetylation, kinetochore-spindle attachment, and gene silencing at centromere.

Minoda A et al. Mol Biol Cell 2005 Jan;16(1):316-27

PMID:32361273 - Requirement of PP2A-B56 Par1 for the Stabilization of the CDK Inhibitor Rum1 and Activation of APC/C Ste9 during Pre-Start G1 in S. pombe.

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PMID:11329175 - Vectors and gene targeting modules for tandem affinity purification in Schizosaccharomyces pombe.

Tasto JJ et al. Yeast 2001 May;18(7):657-62

PMID:16824200 - Schizosaccharomyces pombe homolog of Survivin, Bir1p, exhibits a novel dynamic behavior at the spindle mid-zone.

Rajagopalan S et al. Genes Cells 2006 Jul;11(7):815-27

PMID:8552194 - Interaction of Cdc2 and Cdc18 with a fission yeast ORC2-like protein.

Leatherwood J et al. Nature 1996 Jan 25;379(6563):360-3

PMID:39473973 - Limiting 20S proteasome assembly leads to unbalanced nucleo-cytoplasmic distribution of 26S/30S proteasomes and chronic proteotoxicity.

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PMID:10462529 - Translational control of the cdc25 cell cycle phosphatase: a molecular mechanism coupling mitosis to cell growth.

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PMID:7774573 - Dominant mutants identify new roles for p34cdc2 in mitosis.

Labib K et al. EMBO J 1995 May 15;14(10):2155-65

PMID:8041632 - SCR: novel human suppressors of cdc2/cdc13 mutants of Schizosaccharomyces pombe harbour motifs for RNA binding proteins.

Kanaoka Y et al. Nucleic Acids Res 1994 Jul 11;22(13):2687-93

PMID:15791259 - Fission yeast Mes1p ensures the onset of meiosis II by blocking degradation of cyclin Cdc13p.

Izawa D et al. Nature 2005 Mar 24;434(7032):529-33

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:12399381 - The sal3(+) gene encodes an importin-beta implicated in the nuclear import of Cdc25 in Schizosaccharomyces pombe.

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