protein coding gene - brc1 (SPBC582.05c) - BRCT domain protein Brc1

Gene summary

Standard name

brc1

Systematic ID

SPBC582.05c

Product

BRCT domain protein Brc1

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

Q10337

ORFeome ID

47/47C11

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome II: 426160..428919 reverse strand

Annotation

Protein features

Orthologs

• PAXIP1 (HGNC:8624) Homo sapiens
• brc1 (SJAG_04142) Schizosaccharomyces japonicus
• RTT107 (YHR154W) Saccharomyces cerevisiae

References / Literature

PMID:22927644 - Replication fork collapse and genome instability in a deoxycytidylate deaminase mutant.

Sánchez A et al. Mol Cell Biol 2012 Nov;32(21):4445-54

PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.

Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6

PMID:23656778 - Brc1 links replication stress response and centromere function.

Lee SY et al. Cell Cycle 2013 Jun 01;12(11):1665-71

PMID:15485909 - Rad62 protein functionally and physically associates with the smc5/smc6 protein complex and is required for chromosome integrity and recombination repair in fission yeast.

Morikawa H et al. Mol Cell Biol 2004 Nov;24(21):9401-13

PMID:26368543 - Critical Function of γH2A in S-Phase.

Mejia-Ramirez E et al. PLoS Genet 2015 Sep;11(9):e1005517

PMID:19528228 - Smc5-Smc6-dependent removal of cohesin from mitotic chromosomes.

Outwin EA et al. Mol Cell Biol 2009 Aug;29(16):4363-75

PMID:23628481 - A proteome-wide visual screen identifies fission yeast proteins localizing to DNA double-strand breaks.

Yu Y et al. DNA Repair (Amst) 2013 Jun 01;12(6):433-43

PMID:30148840 - Tdp1 processes chromate-induced single-strand DNA breaks that collapse replication forks.

Ganguly A et al. PLoS Genet 2018 Aug;14(8):e1007595

PMID:27168121 - Discovery of genes involved in mitosis, cell division, cell wall integrity and chromosome segregation through construction of Schizosaccharomyces pombe deletion strains.

Chen JS et al. Yeast 2016 Sep;33(9):507-17

PMID:30348841 - Brc1 Promotes the Focal Accumulation and SUMO Ligase Activity of Smc5-Smc6 during Replication Stress.

Oravcová M et al. Mol Cell Biol 2019 Jan 15;39(2)

PMID:33260998 - High-Throughput Flow Cytometry Combined with Genetic Analysis Brings New Insights into the Understanding of Chromatin Regulation of Cellular Quiescence.

Zahedi Y et al. Int J Mol Sci 2020 Nov 27;21(23)

PMID:20118936 - Schizosaccharomyces pombe genome-wide nucleosome mapping reveals positioning mechanisms distinct from those of Saccharomyces cerevisiae.

Lantermann AB et al. Nat Struct Mol Biol 2010 Feb;17(2):251-7

PMID:23703609 - TORC2 is required to maintain genome stability during S phase in fission yeast.

Schonbrun M et al. J Biol Chem 2013 Jul 05;288(27):19649-60

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:15331764 - Nse1, Nse2, and a novel subunit of the Smc5-Smc6 complex, Nse3, play a crucial role in meiosis.

Pebernard S et al. Mol Biol Cell 2004 Nov;15(11):4866-76

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704

PMID:20661445 - Rad3 decorates critical chromosomal domains with gammaH2A to protect genome integrity during S-Phase in fission yeast.

Rozenzhak S et al. PLoS Genet 2010 Jul 22;6(7):e1001032

PMID:26446992 - Chromatin association of the SMC5/6 complex is dependent on binding of its NSE3 subunit to DNA.

Zabrady K et al. Nucleic Acids Res 2016 Feb 18;44(3):1064-79

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:17277362 - Brc1-mediated rescue of Smc5/6 deficiency: requirement for multiple nucleases and a novel Rad18 function.

Lee KM et al. Genetics 2007 Apr;175(4):1585-95

PMID:28784724 - Multi-BRCT Domain Protein Brc1 Links Rhp18/Rad18 and γH2A To Maintain Genome Stability during S Phase.

Reubens MC et al. Mol Cell Biol 2017 Nov 15;37(22)

PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.

Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514

PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.

Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160

PMID:36793083 - The SAGA histone acetyltransferase module targets SMC5/6 to specific genes.

Mahrik L et al. Epigenetics Chromatin 2023 Feb 16;16(1):6

PMID:10473635 - Rad18 is required for DNA repair and checkpoint responses in fission yeast.

Verkade HM et al. Mol Biol Cell 1999 Sep;10(9):2905-18

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:19547744 - Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Beltrao P et al. PLoS Biol 2009 Jun 16;7(6):e1000134

PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.

Mata J et al. Nat Genet 2002 Sep;32(1):143-7

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:20094029 - gammaH2A binds Brc1 to maintain genome integrity during S-phase.

Williams JS et al. EMBO J 2010 Mar 17;29(6):1136-48

PMID:25965521 - Ku stabilizes replication forks in the absence of Brc1.

Sánchez A et al. PLoS One 2015;10(5):e0126598

PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

Halova L et al. Open Biol 2021 Apr;11(4):200405

PMID:28922417 - Lingering single-strand breaks trigger Rad51-independent homology-directed repair of collapsed replication forks in the polynucleotide kinase/phosphatase mutant of fission yeast.

Sanchez A et al. PLoS Genet 2017 Sep;13(9):e1007013

PMID:30600397 - Recruitment, loading, and activation of the Smc5-Smc6 SUMO ligase.

Oravcová M et al. Curr Genet 2019 Jun;65(3):669-676

PMID:12618370 - Schizosaccharomyces pombe essential genes: a pilot study.

Decottignies A et al. Genome Res 2003 Mar;13(3):399-406

PMID:20885790 - Critical functions of Rpa3/Ssb3 in S-phase DNA damage responses in fission yeast.

Cavero S et al. PLoS Genet 2010 Sep 23;6(9):e1001138

PMID:23358415 - γH2A-binding protein Brc1 affects centromere function in fission yeast.

Lee SY et al. Mol Cell Biol 2013 Apr;33(7):1410-6

PMID:22366461 - Brc1-dependent recovery from replication stress.

Bass KL et al. J Cell Sci 2012 Jun 01;125(Pt 11):2753-64

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.

Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87

PMID:25795664 - Genetic Interaction Landscape Reveals Critical Requirements for Schizosaccharomyces pombe Brc1 in DNA Damage Response Mutants.

Sánchez A et al. G3 (Bethesda) 2015 Mar 19;5(5):953-62

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:20679485 - BRCT domain interactions with phospho-histone H2A target Crb2 to chromatin at double-strand breaks and maintain the DNA damage checkpoint.

Sofueva S et al. Mol Cell Biol 2010 Oct;30(19):4732-43

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:28718400 - Histone H3G34R mutation causes replication stress, homologous recombination defects and genomic instability in S. pombe .

Yadav RK et al. Elife 2017 Jul 18;6

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:39476757 - Characterization of Ksg1 protein kinase-dependent phosphoproteome in the fission yeast S. pombe.

Cipak L et al. Biochem Biophys Res Commun 2024 Oct 25;736:150895

PMID:17213188 - Regulation of the nuclear poly(A)-binding protein by arginine methylation in fission yeast.

Perreault A et al. J Biol Chem 2007 Mar 09;282(10):7552-62

PMID:15972456 - Brc1-mediated DNA repair and damage tolerance.

Sheedy DM et al. Genetics 2005 Oct;171(2):457-68

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7