PomBase home

protein coding gene - ptn1 (SPBC609.02) - phosphatidylinositol-3,4,5-trisphosphate3-phosphatase Ptn1

Gene summary

Standard name
ptn1
Systematic ID
SPBC609.02
Product
phosphatidylinositol-3,4,5-trisphosphate3-phosphatase Ptn1
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O94526
ORFeome ID
15/15H11
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 3161729..3162941 forward strand

Annotation

Disease association

MONDO:0008021 - Cowden syndrome 1

References:

MONDO:0011789 - familial meningioma

References:

MONDO:0013092 - glioma susceptibility 2

References:

MONDO:0011537 - macrocephaly-autism syndrome

References:

MONDO:0700275 - prostate cancer, hereditary

References:

MONDO:0017623 - PTEN hamartoma tumor syndrome

References:

GO biological process

GO:0046854 - phosphatidylinositol phosphate biosynthetic process

References:

GO cellular component

GO:0032153 - cell division site

References:

GO:0031410 - cytoplasmic vesicle

References:

GO:0005829 - cytosol

References:

GO:0005770 - late endosome

References:

GO molecular function

GO:0016314 - phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity

References:

GO:0004439 - phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity

References:

Multi-locus phenotype

FYPO:0006623 - decreased phosphatidylinositol-3,4,5-trisphosphate level in plasma membrane

References:

Genotypes:

FYPO:0006487 - increased cellular phosphatidylinositol-3,4-bisphosphate level

References:

Genotypes:

FYPO:0006624 - increased phosphatidylinositol-3,4,5-trisphosphate level in plasma membrane

References:

Genotypes:

Qualitative gene expression

PomGeneEx:0000012 - RNA level decreased

References:

Quantitative gene expression

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0000251 - decreased cell population growth on galactose carbon source

References:

Genotypes:

FYPO:0000684 - decreased cell population growth on glycerol carbon source

References:

Genotypes:

FYPO:0000250 - decreased cell population growth on proline nitrogen source

References:

Genotypes:

FYPO:0009072 - increased cell population growth on lysine nitrogen source

References:

Genotypes:

FYPO:0006488 - increased cellular phosphatidylinositol-3,4,5-trisphosphate level

References:

Genotypes:

FYPO:0006487 - increased cellular phosphatidylinositol-3,4-bisphosphate level

References:

Genotypes:

FYPO:0006624 - increased phosphatidylinositol-3,4,5-trisphosphate level in plasma membrane

References:

Genotypes:

FYPO:0001309 - increased viability in stationary phase

References:

Genotypes:

FYPO:0006489 - normal cellular phosphatidylinositol-3-phosphate level

References:

Genotypes:

FYPO:0002253 - normal septum location

References:

Genotypes:

FYPO:0009041 - resistance to 2,2′-dipyridyl

References:

Genotypes:

FYPO:0001986 - resistance to 5-fluorouracil

References:

Genotypes:

FYPO:0009030 - resistance to amitrole

References:

Genotypes:

FYPO:0009068 - resistance to ciclopirox olamine

References:

Genotypes:

FYPO:0009038 - resistance to egtazic acid

References:

Genotypes:

FYPO:0000725 - resistance to methyl methanesulfonate

References:

Genotypes:

FYPO:0005253 - resistance to tamoxifen

References:

Genotypes:

FYPO:0002767 - resistance to terbinafine

References:

Genotypes:

FYPO:0003383 - resistance to tert-butyl hydroperoxide

References:

Genotypes:

FYPO:0000096 - sensitive to cadmium

References:

Genotypes:

FYPO:0009080 - sensitive to calcofluor and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0003384 - sensitive to chromium

References:

Genotypes:

FYPO:0000799 - sensitive to diamide

References:

Genotypes:

FYPO:0000022 - shmoo with long tip

References:

Genotypes:

FYPO:0002788 - small vacuoles during vegetative growth

References:

Genotypes:

FYPO:0000647 - vegetative cell lysis

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

Protein features

IDNameInterPro nameDB name
PF22784PTP-SAKPTP-SAKPFAM
cd14497PTP_PTEN-likeCDD
PS00383TYR_PHOSPHATASE_1Tyr_Pase_ASPROSITE_PATTERNS
PS50056TYR_PHOSPHATASE_2Tyr_Pase_domPROSITE_PROFILES
PS51181PPASE_TENSINTensin_phosphatasePROSITE_PROFILES
SSF52799(Phosphotyrosine protein) phosphatases IIProt-tyrosine_phosphatase-likeSUPERFAMILY
G3DSA:3.90.190.10Protein tyrosine phosphatase superfamilyProt-tyrosine_phosphatase-likeGENE3D
PTHR12305PHOSPHATASE WITH HOMOLOGY TO TENSINDual-spec_lipid-protein_phosphPANTHER

Orthologs

References / Literature

PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.
Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160
PMID:27255861 - Genetic evidence for involvement of membrane trafficking in the action of 5-fluorouracil.
Hu L et al. Fungal Genet Biol 2016 Aug;93:17-24
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:27887640 - Functional and regulatory profiling of energy metabolism in fission yeast.
Malecki M et al. Genome Biol 2016 Nov 25;17(1):240
PMID:28410370 - A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.
Dudin O et al. PLoS Genet 2017 Apr;13(4):e1006721
PMID:23050226 - A genetic screen to discover pathways affecting cohesin function in Schizosaccharomyces pombe identifies chromatin effectors.
Chen Z et al. G3 (Bethesda) 2012 Oct;2(10):1161-8
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:26098123 - Promoter nucleosome dynamics regulated by signalling through the CTD code.
Materne P et al. Elife 2015 Jun 22;4:e09008
PMID:20118936 - Schizosaccharomyces pombe genome-wide nucleosome mapping reveals positioning mechanisms distinct from those of Saccharomyces cerevisiae.
Lantermann AB et al. Nat Struct Mol Biol 2010 Feb;17(2):251-7
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:15249580 - A novel phosphatidylinositol(3,4,5)P3 pathway in fission yeast.
Mitra P et al. J Cell Biol 2004 Jul 19;166(2):205-11
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:18818364 - Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast.
Roguev A et al. Science 2008 Oct 17;322(5900):405-10
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:26628015 - Characterization of Tamoxifen as an Antifungal Agent Using the Yeast Schizosaccharomyces Pombe Model Organism.
Zhang X et al. Kobe J Med Sci 2015 Oct 09;61(2):E54-63
PMID:27558664 - Global Fitness Profiling Identifies Arsenic and Cadmium Tolerance Mechanisms in Fission Yeast.
Guo L et al. G3 (Bethesda) 2016 Oct 13;6(10):3317-3333
PMID:28281664 - Genetic interactions and functional analyses of the fission yeast gsk3 and amk2 single and double mutants defective in TORC1-dependent processes.
Rallis C et al. Sci Rep 2017 Mar 10;7:44257
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:29975157 - Analysis of the contribution of phosphoinositides to medial septation in fission yeast highlights the importance of PI(4,5)P 2 for medial contractile ring anchoring.
Snider CE et al. Mol Biol Cell 2018 Sep 01;29(18):2148-2155
PMID:30148840 - Tdp1 processes chromate-induced single-strand DNA breaks that collapse replication forks.
Ganguly A et al. PLoS Genet 2018 Aug;14(8):e1007595