protein coding gene - gta1 (SPBC646.03) - mitochondrial glutamyl-tRNA amidotransferase alpha subunit Gta1

Gene summary

Standard name: gta1
Systematic ID: SPBC646.03
Product: mitochondrial glutamyl-tRNA amidotransferase alpha subunit Gta1
Organism: Schizosaccharomyces pombe (fission yeast)
Synonyms: her2
UniProt ID: O94509
ORFeome ID: 24/24E01
Characterisation status: biological role inferred
Feature type: mRNA gene
Genomic location: chromosome II: 926784..928797 forward strand

Annotation

Disease association

MONDO:0030006 - combined oxidative phosphorylation deficiency 40

References:

PB_REF:0000006

GO biological process

GO:0032543 - mitochondrial translation

References:

GO_REF:0000033

GO cellular component

GO:0005737 - cytoplasm

References:

PMID:16823372

GO:0030956 - glutamyl-tRNA(Gln) amidotransferase complex

References:

GO_REF:0000033

GO:0005759 - mitochondrial matrix

References:

GO_REF:0000111

GO molecular function

GO:0050567 - glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity

References:

GO_REF:0000033

Qualitative gene expression

PomGeneEx:0000011 - RNA level increased

References:

Quantitative gene expression

PBO:0011963 - RNA level

References:

PMID:23101633

Single locus phenotype

FYPO:0002111 - inviable tapered vegetative cell

References:

PMID:23697806

Genotypes:

gta1delta

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

gta1delta

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

ID	Name	InterPro name	DB name
PF01425	Amidase	Amidase_dom	PFAM
PS00571	AMIDASES	Amidase_CS	PROSITE_PATTERNS
SSF75304	Amidase signature (AS) enzymes	AS_sf	SUPERFAMILY
G3DSA:3.90.1300.10	Amidase signature (AS) domain	AS_sf	GENE3D
PTHR11895	TRANSAMIDASE	Amidase	PANTHER
MF_00120	GatA	GatA	HAMAP

Orthologs

QRSL1 (HGNC:21020) Homo sapiens
gta1 (SJAG_02721) Schizosaccharomyces japonicus
HER2 (YMR293C) Saccharomyces cerevisiae

References / Literature

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.: Hayles J et al. Open Biol 2013 May 22;3(5):130053
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.: Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.: Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.: Mata J et al. Nat Genet 2002 Sep;32(1):143-7
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:21511999 - Comparative functional genomics of the fission yeasts.: Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.: Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.: Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
GO_REF:0000033 - Annotation inferences using phylogenetic trees