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protein coding gene - erg9 (SPBC646.05c) - farnesyldiphosphate:farnesyldiphosphatefarnesyltransferase (squalene synthase) Erg9

Gene summary

Standard name
erg9
Systematic ID
SPBC646.05c
Product
farnesyldiphosphate:farnesyldiphosphatefarnesyltransferase (squalene synthase) Erg9
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
P36596
ORFeome ID
32/32H09
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 931002..932472 reverse strand

Annotation

PBO:0003390 - 2.5.1.21

Disease association

MONDO:0032566 - squalene synthase deficiency

References:

GO biological process

GO:0006696 - ergosterol biosynthetic process

References:

GO:0008204 - ergosterol metabolic process

References:

GO:0045338 - farnesyl diphosphate metabolic process

References:

GO cellular component

GO:0098554 - cytoplasmic side of endoplasmic reticulum membrane

References:

GO:0005783 - endoplasmic reticulum

References:

GO:0005789 - endoplasmic reticulum membrane

References:

GO:0042175 - nuclear outer membrane-endoplasmic reticulum membrane network

References:

GO molecular function

GO:0051996 - squalene synthase [NAD(P)H] activity

References:

Modification

MOD:00006 - N-glycosylated residue

References:

MOD:00046 - O-phospho-L-serine

References:

MOD:01148 - ubiquitinylated lysine

References:

Protein sequence feature

SO:0001812 - transmembrane_helix

References:

Qualitative gene expression

PomGeneEx:0000018 - protein level increased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0002420 - inviable after spore germination, single cell division, abnormal cell shape

References:

Genotypes:

FYPO:0002151 - inviable spore

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Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF00494SQS_PSYSqu/phyt_synthsePfam
cd00683Trans_IPPS_HHTrans_IPPS_HHCDD
PS01044SQUALEN_PHYTOEN_SYN_1Squalene/phytoene_synthase_CSPROSITE patterns
PS01045SQUALEN_PHYTOEN_SYN_2Squalene/phytoene_synthase_CSPROSITE patterns
G3DSA:1.10.600.10:FF:000003CATH-FunFam
G3DSA:1.10.600.10Isoprenoid_synthase_dom_sfCATH-Gene3D
SSF48576Isoprenoid_synthase_dom_sfSUPERFAMILY
PTHR11626Trans_IPPS_euk-typePANTHER
TIGR01559squal_synthSqual_synth-likeNCBIFAM
SFLDG01018Squalene/Phytoene_Synthase_LikSqu/phyt_synthseSFLD
SFLDS00005Isoprenoid_Synthase_Type_ISFLD
Transmembrane alpha helixDeepTMHMM

Orthologs

References / Literature

GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:8474436 - Conservation between human and fungal squalene synthetases: similarities in structure, function, and regulation.
Robinson GW et al. Mol Cell Biol 1993 May;13(5):2706-17
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:31474649 - Identification of 15 New Bypassable Essential Genes of Fission Yeast.
Takeda A et al. Cell Struct Funct 2019 Sep 27;44(2):113-119
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:33109728 - High-Throughput Identification of Nuclear Envelope Protein Interactions in Schizosaccharomyces pombe Using an Arrayed Membrane Yeast-Two Hybrid Library.
Varberg JM et al. G3 (Bethesda) 2020 Dec 03;10(12):4649-4663
PMID:26412298 - A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.
Beckley JR et al. Mol Cell Proteomics 2015 Dec;14(12):3132-41
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.
Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.
Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80
PMID:17016471 - Repression of ergosterol level during oxidative stress by fission yeast F-box protein Pof14 independently of SCF.
Tafforeau L et al. EMBO J 2006 Oct 04;25(19):4547-56
PMID:23695164 - Cross-species protein interactome mapping reveals species-specific wiring of stress response pathways.
Das J et al. Sci Signal 2013 May 21;6(276):ra38
PMID:28218250 - Chromatin remodeller Fun30 Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.
Lee J et al. Nat Commun 2017 Feb 20;8:14527
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:22633491 - Mapping N-glycosylation sites across seven evolutionarily distant species reveals a divergent substrate proteome despite a common core machinery.
Zielinska DF et al. Mol Cell 2012 May 25;46(4):542-8