protein coding gene - int6 (SPBC646.09c) - translation initiation factor eIF3e
Gene summary
- Standard name
- int6
- Systematic ID
- SPBC646.09c
- Product
- translation initiation factor eIF3e
- Organism
- Schizosaccharomyces pombe
(fission yeast)
- Synonyms
- yin6, tif305
- UniProt ID
- O94513
- ORFeome ID
- 40/40F02
- Characterisation status
- biological role published
- Feature type
- mRNA gene
- Genomic location
- chromosome II: 938621..940308 reverse strand
Annotation
Qualitative gene expression
Quantitative gene expression
Protein features
| ID | Name | InterPro name | DB name |
| PF09440 | eIF3_N | eIF3e_N | Pfam |
| cd21378 | eIF3E | eIF3e | CDD |
| PS50250 | PCI | PCI_dom | PROSITE profiles |
| SM01186 | eIF3_N | eIF3e_N | SMART |
| PTHR10317 | | eIF3e | PANTHER |
| PIRSF016255 | eIF3e_su6 | eIF3e | PIRSF |
| Coil | | | COILS |
| MF_03004 | eIF3e | eIF3e | HAMAP |
Orthologs
- EIF3E (HGNC:3277) Homo sapiens
- int6 (SJAG_02376) Schizosaccharomyces japonicus
References / Literature
- PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.
- Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6
- PMID:11121040 - Yin6, a fission yeast Int6 homolog, complexes with Moe1 and plays a role in chromosome segregation.
- Yen HC et al. Proc Natl Acad Sci U S A 2000 Dec 19;97(26):14370-5
- PMID:18257517 - Phosphoproteome analysis of fission yeast.
- Wilson-Grady JT et al. J Proteome Res 2008 Mar;7(3):1088-97
- PMID:12136010 - Role of the Tsc1-Tsc2 complex in signaling and transport across the cell membrane in the fission yeast Schizosaccharomyces pombe.
- Matsumoto S et al. Genetics 2002 Jul;161(3):1053-63
- PMID:12553909 - Schizosaccharomyces pombe Int6 and Ras homologs regulate cell division and mitotic fidelity via the proteasome.
- Yen HC et al. Cell 2003 Jan 24;112(2):207-17
- PMID:19061185 - Fission yeast translation initiation factor 3 subunit eIF3h is not essential for global translation initiation, but deletion of eif3h+ affects spore formation.
- Ray A et al. Yeast 2008 Nov;25(11):809-23
- PMID:19547744 - Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.
- Beltrao P et al. PLoS Biol 2009 Jun 16;7(6):e1000134
- PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
- Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
- PMID:11705997 - Moe1 and spInt6, the fission yeast homologues of mammalian translation initiation factor 3 subunits p66 (eIF3d) and p48 (eIF3e), respectively, are required for stable association of eIF3 subunits.
- Bandyopadhyay A et al. J Biol Chem 2002 Jan 18;277(3):2360-7
- GO_REF:0000002 - Comments
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- PMID:20875427 - The roles of stress-activated Sty1 and Gcn2 kinases and of the protooncoprotein homologue Int6/eIF3e in responses to endogenous oxidative stress during histidine starvation.
- Nemoto N et al. J Mol Biol 2010 Nov 26;404(2):183-201
- GO_REF:0000104 - Electronic Gene Ontology annotations created by transferring manual GO annotations between related proteins based on shared sequence features.
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- PMID:23163955 - Analysis of stress-induced duplex destabilization (SIDD) properties of replication origins, genes and intergenes in the fission yeast, Schizosaccharomyces pombe.
- Yadav MP et al. BMC Res Notes 2012 Nov 19;5:643
- PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
- Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
- PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
- Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
- PMID:27298342 - Identification of S-phase DNA damage-response targets in fission yeast reveals conservation of damage-response networks.
- Willis NA et al. Proc Natl Acad Sci U S A 2016 Jun 28;113(26):E3676-85
- PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.
- Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514
- PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
- Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
- PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.
- Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160
- PMID:34984977 - Functional profiling of long intergenic non-coding RNAs in fission yeast.
- Rodriguez-Lopez M et al. Elife 2022 Jan 05;11
- PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
- Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
- PMID:18502752 - Int6/eIF3e promotes general translation and Atf1 abundance to modulate Sty1 MAPK-dependent stress response in fission yeast.
- Udagawa T et al. J Biol Chem 2008 Aug 08;283(32):22063-75
- PMID:28218250 - Chromatin remodeller Fun30 Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.
- Lee J et al. Nat Commun 2017 Feb 20;8:14527
- PMID:12006658 - Sum1, a component of the fission yeast eIF3 translation initiation complex, is rapidly relocalized during environmental stress and interacts with components of the 26S proteasome.
- Dunand-Sauthier I et al. Mol Biol Cell 2002 May;13(5):1626-40
- PMID:22119525 - SIN-inhibitory phosphatase complex promotes Cdc11p dephosphorylation and propagates SIN asymmetry in fission yeast.
- Singh NS et al. Curr Biol 2011 Dec 06;21(23):1968-78
- PMID:39476757 - Characterization of Ksg1 protein kinase-dependent phosphoproteome in the fission yeast S. pombe.
- Cipak L et al. Biochem Biophys Res Commun 2024 Oct 25;736:150895
- PMID:26412298 - A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.
- Beckley JR et al. Mol Cell Proteomics 2015 Dec;14(12):3132-41
- PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
- Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
- PMID:26537787 - Targeting of SUMO substrates to a Cdc48-Ufd1-Npl4 segregase and STUbL pathway in fission yeast.
- Køhler JB et al. Nat Commun 2015 Nov 05;6:8827
- PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
- Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
- PMID:35320724 - Cdc48 influence on separase levels is independent of mitosis and suggests translational sensitivity of separase.
- Vijayakumari D et al. Cell Rep 2022 Mar 22;38(12):110554
- PMID:30355493 - Expanded Interactome of the Intrinsically Disordered Protein Dss1.
- Schenstrøm SM et al. Cell Rep 2018 Oct 23;25(4):862-870
- PMID:21511999 - Comparative functional genomics of the fission yeasts.
- Rhind N et al. Science 2011 May 20;332(6032):930-6
- PMID:11134033 - Fission yeast homolog of murine Int-6 protein, encoded by mouse mammary tumor virus integration site, is associated with the conserved core subunits of eukaryotic translation initiation factor 3.
- Akiyoshi Y et al. J Biol Chem 2001 Mar 30;276(13):10056-62
- PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
- Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
- PMID:19818717 - The eIF3 interactome reveals the translasome, a supercomplex linking protein synthesis and degradation machineries.
- Sha Z et al. Mol Cell 2009 Oct 09;36(1):141-52
- PMID:24634168 - Proteome-wide search for PP2A substrates in fission yeast.
- Bernal M et al. Proteomics 2014 Jun;14(11):1367-80
- PMID:27918601 - Identifying genes required for respiratory growth of fission yeast.
- Malecki M et al. Wellcome Open Res 2016;1:12
- PMID:19139265 - The SH3 domains of two PCH family members cooperate in assembly of the Schizosaccharomyces pombe contractile ring.
- Roberts-Galbraith RH et al. J Cell Biol 2009 Jan 12;184(1):113-27
- PMID:11071923 - Fission yeast Int6 is not essential for global translation initiation, but deletion of int6(+) causes hypersensitivity to caffeine and affects spore formation.
- Bandyopadhyay A et al. Mol Biol Cell 2000 Nov;11(11):4005-18
- PMID:16278451 - Activation of AP-1-dependent transcription by a truncated translation initiation factor.
- Jenkins CC et al. Eukaryot Cell 2005 Nov;4(11):1840-50
- PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
- Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
- PMID:21386897 - Systematic two-hybrid and comparative proteomic analyses reveal novel yeast pre-mRNA splicing factors connected to Prp19.
- Ren L et al. PLoS One 2011 Feb 28;6(2):e16719
- PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
- Hayles J et al. Open Biol 2013 May 22;3(5):130053
- PMID:11071922 - A fission yeast homolog of Int-6, the mammalian oncoprotein and eIF3 subunit, induces drug resistance when overexpressed.
- Crane R et al. Mol Biol Cell 2000 Nov;11(11):3993-4003
- PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
- Rodríguez-López M et al. Elife 2023 Oct 03;12
- PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
- Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
- PMID:15904532 - PCI proteins eIF3e and eIF3m define distinct translation initiation factor 3 complexes.
- Zhou C et al. BMC Biol 2005 May 17;3:14
- PMID:36478272 - Translation-complex profiling of fission yeast cells reveals dynamic rearrangements of scanning ribosomal subunits upon nutritional stress.
- Duncan CDS et al. Nucleic Acids Res 2022 Dec 09;50(22):13011-13025
- PMID:28281664 - Genetic interactions and functional analyses of the fission yeast gsk3 and amk2 single and double mutants defective in TORC1-dependent processes.
- Rallis C et al. Sci Rep 2017 Mar 10;7:44257
- PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.
- Halova L et al. Open Biol 2021 Apr;11(4):200405
- PMID:20668161 - Proteasome nuclear import mediated by Arc3 can influence efficient DNA damage repair and mitosis in Schizosaccharomyces pombe.
- Cabrera R et al. Mol Biol Cell 2010 Sep 15;21(18):3125-36
