protein coding gene - sds23 (SPBC646.13) - serine/threonine protein phosphatase PP2A inhibitor Sds23/Moc1

Gene summary

Standard name

sds23

Systematic ID

SPBC646.13

Product

serine/threonine protein phosphatase PP2A inhibitor Sds23/Moc1

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

psp1, moc1

UniProt ID

Q09826

ORFeome ID

32/32F09

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome II: 950777..952292 forward strand

Annotation

Protein features

Orthologs

• sds23 (SJAG_02380) Schizosaccharomyces japonicus
• SDS24 (YBR214W) Saccharomyces cerevisiae
• SDS23 (YGL056C) Saccharomyces cerevisiae

References / Literature

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704

PMID:1944266 - The fission yeast dis3+ gene encodes a 110-kDa essential protein implicated in mitotic control.

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PMID:26167880 - SR protein kinases promote splicing of nonconsensus introns.

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PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

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PMID:25411338 - Mechanisms of expression and translocation of major fission yeast glucose transporters regulated by CaMKK/phosphatases, nuclear shuttling, and TOR.

Saitoh S et al. Mol Biol Cell 2015 Jan 15;26(2):373-86

PMID:33280247 - The phosphatase inhibitor Sds23 promotes symmetric spindle positioning in fission yeast.

Schutt KL et al. Cytoskeleton (Hoboken) 2020 Dec;77(12):544-557

PMID:34984977 - Functional profiling of long intergenic non-coding RNAs in fission yeast.

Rodriguez-Lopez M et al. Elife 2022 Jan 05;11

PMID:35924983 - Genetic-interaction screens uncover novel biological roles and regulators of transcription factors in fission yeast.

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PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

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PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.

Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963

PMID:8978689 - Requirement for PP1 phosphatase and 20S cyclosome/APC for the onset of anaphase is lessened by the dosage increase of a novel gene sds23+.

Ishii K et al. EMBO J 1996 Dec 02;15(23):6629-40

PMID:28410370 - A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.

Dudin O et al. PLoS Genet 2017 Apr;13(4):e1006721

PMID:21680738 - Glucose controls phosphoregulation of hydroxymethylglutaryl coenzyme A reductase through the protein phosphatase 2A-related phosphatase protein, Ppe1, and Insig in fission yeast.

Burg JS et al. J Biol Chem 2011 Aug 05;286(31):27139-46

PMID:31553675 - The phosphatase inhibitor Sds23 regulates cell division symmetry in fission yeast.

Schutt KL et al. Mol Biol Cell 2019 Nov 01;30(23):2880-2889

PMID:28223368 - Phosphatases Generate Signal Specificity Downstream of Ssp1 Kinase in Fission Yeast.

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PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

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PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.

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PMID:25452419 - Parallel profiling of fission yeast deletion mutants for proliferation and for lifespan during long-term quiescence.

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PMID:19547744 - Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

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PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:16273369 - Moc3, a novel Zn finger type protein involved in sexual development, ascus formation, and stress response of Schizosaccharomyces pombe.

Goldar MM et al. Curr Genet 2005 Dec;48(6):345-55

PMID:21869531 - Complex formation, phosphorylation, and localization of protein kinase A of Schizosaccharomyces pombe upon glucose starvation.

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PMID:34296454 - The TOR-dependent phosphoproteome and regulation of cellular protein synthesis.

Mak T et al. EMBO J 2021 Aug 16;40(16):e107911

PMID:16819157 - Involvement of Moc1 in sexual development and survival of Schizosaccharomyces pombe.

Yakura M et al. Biosci Biotechnol Biochem 2006 Jul;70(7):1740-9

PMID:1846086 - S. pombe gene sds22+ essential for a midmitotic transition encodes a leucine-rich repeat protein that positively modulates protein phosphatase-1.

Ohkura H et al. Cell 1991 Jan 11;64(1):149-57

PMID:21801748 - Regulation of HMG-CoA reductase in mammals and yeast.

Burg JS et al. Prog Lipid Res 2011 Oct;50(4):403-10

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:22540037 - Predicting the fission yeast protein interaction network.

Pancaldi V et al. G3 (Bethesda) 2012 Apr;2(4):453-67

PMID:26152587 - TORC1 Regulates Developmental Responses to Nitrogen Stress via Regulation of the GATA Transcription Factor Gaf1.

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PMID:27053105 - Mga2 Transcription Factor Regulates an Oxygen-responsive Lipid Homeostasis Pathway in Fission Yeast.

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PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.

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PMID:26412298 - A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

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PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.

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PMID:10582241 - Control of metaphase-anaphase progression by proteolysis: cyclosome function regulated by the protein kinase A pathway, ubiquitination and localization.

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PMID:18794354 - Schizosaccharomyces pombe Ddb1 recruits substrate-specific adaptor proteins through a novel protein motif, the DDB-box.

Fukumoto Y et al. Mol Cell Biol 2008 Nov;28(22):6746-56

PMID:23950735 - Global analysis of fission yeast mating genes reveals new autophagy factors.

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PMID:24013502 - Epe1 recruits BET family bromodomain protein Bdf2 to establish heterochromatin boundaries.

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PMID:16041152 - Functional conservation between fission yeast moc1/sds23 and its two orthologs, budding yeast SDS23 and SDS24, and phenotypic differences in their disruptants.

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PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

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PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.

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PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.

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PMID:20118936 - Schizosaccharomyces pombe genome-wide nucleosome mapping reveals positioning mechanisms distinct from those of Saccharomyces cerevisiae.

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PMID:9242669 - A novel protein, Psp1, essential for cell cycle progression of Schizosaccharomyces pombe is phosphorylated by Cdc2-Cdc13 upon entry into G0-like stationary phase of cell growth.

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PMID:22730331 - Dual recruitment of Cdc48 (p97)-Ufd1-Npl4 ubiquitin-selective segregase by small ubiquitin-like modifier protein (SUMO) and ubiquitin in SUMO-targeted ubiquitin ligase-mediated genome stability functions.

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GO_REF:0000051 - S. pombe keyword mapping

PMID:30116786 - Genetic regulation of mitotic competence in G 0 quiescent cells.

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PMID:25076038 - Large scale screening of genetic interaction with sgf73(+) in fission yeast.

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PMID:29852001 - New insights into donor directionality of mating-type switching in Schizosaccharomyces pombe.

Maki T et al. PLoS Genet 2018 May;14(5):e1007424

PMID:23640764 - Phosphorylations of Sds23/Psp1/Moc1 by stress-activated kinase and cAMP-dependent kinase are essential for regulating cell viability in prolonged stationary phase.

Jang YJ et al. Yeast 2013 Oct;30(10):379-94

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

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PMID:19682301 - A large complex mediated by Moc1, Moc2 and Cpc2 regulates sexual differentiation in fission yeast.

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PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

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PMID:20536828 - A screen for genes involved in respiration control and longevity in Schizosaccharomyces pombe.

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PMID:29432178 - General amino acid control in fission yeast is regulated by a nonconserved transcription factor, with functions analogous to Gcn4/Atf4.

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PMID:21511999 - Comparative functional genomics of the fission yeasts.

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PMID:39476757 - Characterization of Ksg1 protein kinase-dependent phosphoproteome in the fission yeast S. pombe.

Cipak L et al. Biochem Biophys Res Commun 2024 Oct 25;736:150895

PMID:15507118 - An interactive gene network for securin-separase, condensin, cohesin, Dis1/Mtc1 and histones constructed by mass transformation.

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PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:19371376 - Schizosaccharomyces pombe cell division cycle under limited glucose requires Ssp1 kinase, the putative CaMKK, and Sds23, a PP2A-related phosphatase inhibitor.

Hanyu Y et al. Genes Cells 2009 May;14(5):539-54

PMID:35820914 - Antagonistic effects of mitochondrial matrix and intermembrane space proteases on yeast aging.

Vega M et al. BMC Biol 2022 Jul 12;20(1):160