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protein coding gene - dic1 (SPBC646.17c) - meiotic dynein intermediate chain Dic1

Gene summary

Standard name
dic1
Systematic ID
SPBC646.17c
Product
meiotic dynein intermediate chain Dic1
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
SPBC855.01c, SPBP35G2.01c, mug44
UniProt ID
O94518
ORFeome ID
35/35F04
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 958669..960389 reverse strand

Annotation

Disease association

MONDO:0032779 - neurodevelopmental disorder with microcephaly and structural brain anomalies

References:

GO biological process

GO:0030989 - dynein-driven meiotic oscillatory nuclear movement

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GO cellular component

GO:0030981 - cortical microtubule cytoskeleton

References:

GO:0005868 - cytoplasmic dynein complex

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GO:0005829 - cytosol

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GO:0035974 - meiotic spindle pole body

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GO molecular function

GO:0045504 - dynein heavy chain binding

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GO:0045503 - dynein light chain binding

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Protein features

PBO:0111751 - WD repeat protein

Qualitative gene expression

PomGeneEx:0000018 - protein level increased

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PomGeneEx:0000011 - RNA level increased

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Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0000151 - abnormal meiotic chromosome segregation

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Genotypes:

FYPO:0003066 - abnormal sporulation resulting in formation of ascus with fewer than four spores

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Genotypes:

FYPO:0000927 - abolished horsetail movement

References:

Genotypes:

FYPO:0000485 - decreased meiotic recombination

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Genotypes:

FYPO:0000933 - decreased protein localization to microtubule cytoskeleton during vegetative growth

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Genotypes:

FYPO:0000940 - decreased protein localization to mitotic spindle pole body

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Genotypes:

FYPO:0004806 - incomplete cell wall disassembly at cell fusion site

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Genotypes:

FYPO:0003848 - sensitive to hydrazinocurcumin

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

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Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0000055 - no apparent S. cerevisiae ortholog

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF00400WD40WD40_rptPFAM
PS50082WD_REPEATS_2WD40_rptPROSITE_PROFILES
SM00320WD40_4WD40_rptSMART
G3DSA:2.130.10.10:FF:000745FUNFAM
SSF50978WD40 repeat-likeWD40_repeat_dom_sfSUPERFAMILY
G3DSA:2.130.10.10WD40/YVTN_repeat-like_dom_sfGENE3D
PTHR12442DYNEIN INTERMEDIATE CHAINDynein_ICPANTHER

Orthologs

References / Literature

PMID:18309270 - Genome-wide drug-induced haploinsufficient screening of fission yeast for identification of hydrazinocurcumin targets.
Baek ST et al. J Microbiol Biotechnol 2008 Feb;18(2):263-9
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:23658229 - Red5 and three nuclear pore components are essential for efficient suppression of specific mRNAs during vegetative growth of fission yeast.
Sugiyama T et al. Nucleic Acids Res 2013 Jul;41(13):6674-86
PMID:15509865 - The p150-Glued Ssm4p regulates microtubular dynamics and nuclear movement in fission yeast.
Niccoli T et al. J Cell Sci 2004 Nov 01;117(Pt 23):5543-56
PMID:25736293 - Dynactin and Num1 cooperate to establish the cortical anchoring of cytoplasmic dynein in S. pombe.
Fujita I et al. J Cell Sci 2015 Apr 15;128(8):1555-67
PMID:26670050 - Regulation of mRNA Levels by Decay-Promoting Introns that Recruit the Exosome Specificity Factor Mmi1.
Kilchert C et al. Cell Rep 2015 Dec 22;13(11):2504-2515
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:28410370 - A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.
Dudin O et al. PLoS Genet 2017 Apr;13(4):e1006721
PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.
Mata J et al. Nat Genet 2002 Sep;32(1):143-7
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:20298435 - Contribution of dynein light intermediate and intermediate chains to subcellular localization of the dynein-dynactin motor complex in Schizosaccharomyces pombe.
Fujita I et al. Genes Cells 2010 Apr 01;15(4):359-72
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:25375137 - Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.
Hasan A et al. PLoS Genet 2014 Nov;10(11):e1004684
PMID:25869666 - Microtubule minus end motors kinesin-14 and dynein drive nuclear congression in parallel pathways.
Scheffler K et al. J Cell Biol 2015 Apr 13;209(1):47-58
PMID:29259000 - Genes Important for Schizosaccharomyces pombe Meiosis Identified Through a Functional Genomics Screen.
Blyth J et al. Genetics 2018 Feb;208(2):589-603
PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.
Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105