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protein coding gene - rpc1 (SPBC651.08c) - DNA-directed RNA polymerase III complex large subunit Rpc1

Gene summary

Standard name
rpc1
Systematic ID
SPBC651.08c
Product
DNA-directed RNA polymerase III complex large subunit Rpc1
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O94666
ORFeome ID
30/30G05
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome II: 1249831..1254446 reverse strand

Annotation

PBO:0000445 - 2.7.7.6

Disease association

MONDO:0011897 - leukodystrophy, hypomyelinating, 7, with or without oligodontia and/or hypogonadotropic hypogonadism

References:

MONDO:0009910 - Wiedemann-Rautenstrauch syndrome

References:

GO biological process

GO:0042797 - tRNA transcription by RNA polymerase III

References:

GO cellular component

GO:0000785 - chromatin

References:

GO:0005666 - RNA polymerase III complex

References:

GO molecular function

GO:0003677 - DNA binding

References:

GO:0003899 - DNA-directed RNA polymerase activity

References:

Modification

MOD:01148 - ubiquitinylated lysine

References:

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0002151 - inviable spore

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0001029 - resistance to canavanine

References:

Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF00623RNA_pol_Rpb1_2RNA_pol_asuPfam
PF04983RNA_pol_Rpb1_3RNA_pol_Rpb1_3Pfam
PF04997RNA_pol_Rpb1_1RNA_pol_Rpb1_1Pfam
PF04998RNA_pol_Rpb1_5RNA_pol_Rpb1_5Pfam
PF05000RNA_pol_Rpb1_4RNA_pol_Rpb1_4Pfam
cd02583RNAP_III_RPC1_NRNAP_III_RPC1_NCDD
cd02736RNAP_III_Rpc1_CRNAP_III_Rpc1_CCDD
SM00663RPOLA_NRNA_pol_NSMART
G3DSA:1.10.132.30:FF:000001CATH-FunFam
G3DSA:1.10.150.390:FF:000004CATH-FunFam
G3DSA:1.10.274.100:FF:000008CATH-FunFam
G3DSA:2.40.40.20:FF:000019CATH-FunFam
G3DSA:4.10.860.120:FF:000004CATH-FunFam
G3DSA:1.10.132.30Rpb1_funnel_sfCATH-Gene3D
G3DSA:1.10.150.390CATH-Gene3D
G3DSA:1.10.274.100RNA_pol_Rpb1_3_sfCATH-Gene3D
G3DSA:2.40.40.20CATH-Gene3D
G3DSA:3.30.1490.180CATH-Gene3D
G3DSA:4.10.860.120RNA_pol_Rpb1_clamp_domainCATH-Gene3D
G3DSA:6.10.250.2940CATH-Gene3D
G3DSA:6.20.50.80CATH-Gene3D
SSF64484SUPERFAMILY
PTHR48446RPC1PANTHER
NF006336PRK08566.1NCBIFAM

Orthologs

References / Literature

PMID:26412298 - A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.
Beckley JR et al. Mol Cell Proteomics 2015 Dec;14(12):3132-41
GO_REF:0000033 - Annotation inferences using phylogenetic trees
GO_REF:0000002 - Comments
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:27611590 - Pfh1 Is an Accessory Replicative Helicase that Interacts with the Replisome to Facilitate Fork Progression and Preserve Genome Integrity.
McDonald KR et al. PLoS Genet 2016 Sep;12(9):e1006238
PMID:24013502 - Epe1 recruits BET family bromodomain protein Bdf2 to establish heterochromatin boundaries.
Wang J et al. Genes Dev 2013 Sep 01;27(17):1886-902
PMID:25392932 - RNA processing factors Swd2.2 and Sen1 antagonize RNA Pol III-dependent transcription and the localization of condensin at Pol III genes.
Legros P et al. PLoS Genet 2014 Nov;10(11):e1004794
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:31294478 - Senataxin homologue Sen1 is required for efficient termination of RNA polymerase III transcription.
Rivosecchi J et al. EMBO J 2019 Aug 15;38(16):e101955
PMID:19443688 - Diverse roles of HP1 proteins in heterochromatin assembly and functions in fission yeast.
Fischer T et al. Proc Natl Acad Sci U S A 2009 Jun 02;106(22):8998-9003
PMID:22540037 - Predicting the fission yeast protein interaction network.
Pancaldi V et al. G3 (Bethesda) 2012 Apr;2(4):453-67
PMID:23163955 - Analysis of stress-induced duplex destabilization (SIDD) properties of replication origins, genes and intergenes in the fission yeast, Schizosaccharomyces pombe.
Yadav MP et al. BMC Res Notes 2012 Nov 19;5:643
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:38404922 - Diverse modes of chromosome terminal deletion in spontaneous canavanine-resistant Schizosaccharomyces pombe mutants.
Lyu XH et al. MicroPubl Biol 2024;2024
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:31883795 - Positioning Heterochromatin at the Nuclear Periphery Suppresses Histone Turnover to Promote Epigenetic Inheritance.
Holla S et al. Cell 2020 Jan 09;180(1):150-164.e15
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83