protein coding gene - nse5 (SPBC651.10) - Smc5-6 complex non-SMC subunit Nse5
Gene summary
- Standard name
- nse5
- Systematic ID
- SPBC651.10
- Product
- Smc5-6 complex non-SMC subunit Nse5
- Organism
- Schizosaccharomyces pombe
(fission yeast)
- UniProt ID
- O94668
- ORFeome ID
- 18/18D12
- Characterisation status
- biological role published
- Feature type
- mRNA gene
- Genomic location
- chromosome II: 1257903..1259192 forward strand
Annotation
Qualitative gene expression
Quantitative gene expression
Protein features
| ID | Name | InterPro name | DB name |
| PF08691 | Nse5 | DNA_repair_Nse5/Nse6 | PFAM |
Orthologs
- SLF1 (HGNC:25408) Homo sapiens
- nse5 (SJAG_04932) Schizosaccharomyces japonicus
- NSE5 (YML023C) Saccharomyces cerevisiae
References / Literature
- PMID:28945192 - Regulated Ire1-dependent mRNA decay requires no-go mRNA degradation to maintain endoplasmic reticulum homeostasis in S. pombe .
- Guydosh NR et al. Elife 2017 Sep 25;6
- PMID:23695164 - Cross-species protein interactome mapping reveals species-specific wiring of stress response pathways.
- Das J et al. Sci Signal 2013 May 21;6(276):ra38
- PMID:22927644 - Replication fork collapse and genome instability in a deoxycytidylate deaminase mutant.
- Sánchez A et al. Mol Cell Biol 2012 Nov;32(21):4445-54
- PMID:17005570 - The Smc5-Smc6 DNA repair complex. bridging of the Smc5-Smc6 heads by the KLEISIN, Nse4, and non-Kleisin subunits.
- Palecek J et al. J Biol Chem 2006 Dec 01;281(48):36952-9
- PMID:36793083 - The SAGA histone acetyltransferase module targets SMC5/6 to specific genes.
- Mahrik L et al. Epigenetics Chromatin 2023 Feb 16;16(1):6
- PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.
- Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
- PMID:32546830 - A role of the Nse4 kleisin and Nse1/Nse3 KITE subunits in the ATPase cycle of SMC5/6.
- Vondrova L et al. Sci Rep 2020 Jun 16;10(1):9694
- PMID:17762865 - SUMO-targeted ubiquitin ligases in genome stability.
- Prudden J et al. EMBO J 2007 Sep 19;26(18):4089-101
- PMID:19264558 - Screening a genome-wide S. pombe deletion library identifies novel genes and pathways involved in genome stability maintenance.
- Deshpande GP et al. DNA Repair (Amst) 2009 May 01;8(5):672-9
- PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
- Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
- GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
-
- PMID:25002536 - A novel histone deacetylase complex in the control of transcription and genome stability.
- Zilio N et al. Mol Cell Biol 2014 Sep 15;34(18):3500-14
- PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
- Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
- PMID:29259000 - Genes Important for Schizosaccharomyces pombe Meiosis Identified Through a Functional Genomics Screen.
- Blyth J et al. Genetics 2018 Feb;208(2):589-603
- PMID:18931302 - Significant conservation of synthetic lethal genetic interaction networks between distantly related eukaryotes.
- Dixon SJ et al. Proc Natl Acad Sci U S A 2008 Oct 28;105(43):16653-8
- PMID:18684775 - A genome-wide screen of genes involved in cadmium tolerance in Schizosaccharomyces pombe.
- Kennedy PJ et al. Toxicol Sci 2008 Nov;106(1):124-39
- PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
- Hayles J et al. Open Biol 2013 May 22;3(5):130053
- PMID:15331764 - Nse1, Nse2, and a novel subunit of the Smc5-Smc6 complex, Nse3, play a crucial role in meiosis.
- Pebernard S et al. Mol Biol Cell 2004 Nov;15(11):4866-76
- PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.
- Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6
- PMID:21965289 - Nsk1 ensures accurate chromosome segregation by promoting association of kinetochores to spindle poles during anaphase B.
- Buttrick GJ et al. Mol Biol Cell 2011 Dec;22(23):4486-502
- PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
- Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
- PMID:25552606 - Identification of new players in cell division, DNA damage response, and morphogenesis through construction of Schizosaccharomyces pombe deletion strains.
- Chen JS et al. G3 (Bethesda) 2014 Dec 31;5(3):361-70
- PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
- Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
- PMID:30348841 - Brc1 Promotes the Focal Accumulation and SUMO Ligase Activity of Smc5-Smc6 during Replication Stress.
- Oravcová M et al. Mol Cell Biol 2019 Jan 15;39(2)
- PMID:25483073 - Chromosome segregation and organization are targets of 5'-Fluorouracil in eukaryotic cells.
- Mojardín L et al. Cell Cycle 2015;14(2):206-18
- PMID:21215368 - The Cul4-Ddb1(Cdt)² ubiquitin ligase inhibits invasion of a boundary-associated antisilencing factor into heterochromatin.
- Braun S et al. Cell 2011 Jan 07;144(1):41-54
- PMID:16478984 - The Nse5-Nse6 dimer mediates DNA repair roles of the Smc5-Smc6 complex.
- Pebernard S et al. Mol Cell Biol 2006 Mar;26(5):1617-30
- PMID:21511999 - Comparative functional genomics of the fission yeasts.
- Rhind N et al. Science 2011 May 20;332(6032):930-6
- PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
- Rodríguez-López M et al. Elife 2023 Oct 03;12
- PMID:30600397 - Recruitment, loading, and activation of the Smc5-Smc6 SUMO ligase.
- Oravcová M et al. Curr Genet 2019 Jun;65(3):669-676
