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protein coding gene - egt2 (SPBC660.12c) - hercynylcysteine sulfoxide lyase activity (ergothioneine-forming) Egt2

Gene summary

Standard name
egt2
Systematic ID
SPBC660.12c
Product
hercynylcysteine sulfoxide lyase activity (ergothioneine-forming) Egt2
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O94431
ORFeome ID
18/18F12
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 215522..218349 reverse strand

Annotation

GO biological process

GO:0052699 - ergothioneine biosynthetic process

References:

GO:1903257 - selenoneine biosynthetic process

References:

GO cellular component

GO:0005829 - cytosol

References:

GO:0005634 - nucleus

References:

GO molecular function

GO:1990411 - hercynylcysteine sulfoxide lyase activity (ergothioneine-forming)

References:

Modification

MOD:00128 - N6-pyridoxal phosphate-L-lysine

References:

Multi-locus phenotype

FYPO:0003523 - increased cellular hercynylselenocysteine level

References:

Genotypes:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0003521 - decreased cellular L-ergothioneine level

References:

Genotypes:

FYPO:0003522 - increased cellular hercynylcysteine sulfoxide level

References:

Genotypes:

FYPO:0001357 - normal vegetative cell population growth

References:

Genotypes:

FYPO:0009038 - resistance to egtazic acid

References:

Genotypes:

FYPO:0009043 - resistance to potassium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0000055 - no apparent S. cerevisiae ortholog

Protein features

IDNameInterPro nameDB name
PF00266Aminotran_5Aminotrans_V_domPfam
G3DSA:3.40.640.10PyrdxlP-dep_Trfase_majorCATH-Gene3D
G3DSA:3.90.1150.10PyrdxlP-dep_Trfase_smallCATH-Gene3D
SSF53383PyrdxlP-dep_TrfaseSUPERFAMILY
PTHR43092PANTHER

Orthologs

References / Literature

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:19714215 - The fission yeast homeodomain protein Yox1p binds to MBF and confines MBF-dependent cell-cycle transcription to G1-S via negative feedback.
Aligianni S et al. PLoS Genet 2009 Aug;5(8):e1000626
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:24828577 - Genetic and metabolomic dissection of the ergothioneine and selenoneine biosynthetic pathway in the fission yeast, S. pombe, and construction of an overproduction system.
Pluskal T et al. PLoS One 2014;9(5):e97774
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.
Skribbe M et al. Mol Cell 2025 Feb 19;
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83