protein coding gene - prp1 (SPBC6B1.07) - U4/U6 x U5 tri-snRNP complex subunit Prp1

Gene summary

Standard name

prp1

Systematic ID

SPBC6B1.07

Product

U4/U6 x U5 tri-snRNP complex subunit Prp1

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

zer1

UniProt ID

Q12381

ORFeome ID

47/47B06

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome II: 2641921..2644897 forward strand

Annotation

Protein features

Orthologs

• PRPF6 (HGNC:15860) Homo sapiens
• prp1 (SJAG_00643) Schizosaccharomyces japonicus
• PRP6 (YBR055C) Saccharomyces cerevisiae

References / Literature

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.

Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:21386897 - Systematic two-hybrid and comparative proteomic analyses reveal novel yeast pre-mRNA splicing factors connected to Prp19.

Ren L et al. PLoS One 2011 Feb 28;6(2):e16719

PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.

Strachan J et al. J Cell Sci 2023 Dec 01;136(23)

PMID:2798130 - Splicing of the U6 RNA precursor is impaired in fission yeast pre-mRNA splicing mutants.

Potashkin J et al. Nucleic Acids Res 1989 Oct 11;17(19):7821-31

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:8862522 - A connection between pre-mRNA splicing and the cell cycle in fission yeast: cdc28+ is allelic with prp8+ and encodes an RNA-dependent ATPase/helicase.

Lundgren K et al. Mol Biol Cell 1996 Jul;7(7):1083-94

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:16133344 - Multiple genetic and biochemical interactions of Brr2, Prp8, Prp31, Prp1 and Prp4 kinase suggest a function in the control of the activation of spliceosomes in Schizosaccharomyces pombe.

Bottner CA et al. Curr Genet 2005 Sep;48(3):151-61

PMID:23754748 - Splicing functions and global dependency on fission yeast slu7 reveal diversity in spliceosome assembly.

Banerjee S et al. Mol Cell Biol 2013 Aug;33(16):3125-36

PMID:2721492 - Pre-mRNA splicing mutants of Schizosaccharomyces pombe.

Potashkin J et al. EMBO J 1989 Feb;8(2):551-9

PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

Halova L et al. Open Biol 2021 Apr;11(4):200405

PMID:20028739 - Splicing factor Spf30 assists exosome-mediated gene silencing in fission yeast.

Bernard P et al. Mol Cell Biol 2010 Mar;30(5):1145-57

PMID:20007600 - The N-terminus of Prp1 (Prp6/U5-102 K) is essential for spliceosome activation in vivo.

Lützelberger M et al. Nucleic Acids Res 2010 Mar;38(5):1610-22

PMID:37637271 - Isolation of mutant alleles of the U6 snRNA m 6 A methyltransferase Mtl16 and characterization of their genetic interactions with splicing mutants in Schizosaccharomyces pombe .

Willet AH et al. MicroPubl Biol 2023;2023

PMID:27350684 - Mutant allele of rna14 in fission yeast affects pre-mRNA splicing.

Yadav S et al. J Genet 2016 Jun;95(2):389-97

PMID:9003295 - Isolation of novel pre-mRNA splicing mutants of Schizosaccharomyces pombe.

Urushiyama S et al. Mol Gen Genet 1996 Nov 27;253(1-2):118-27

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.

Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323

PMID:28446597 - The histone variant H2A.Z promotes splicing of weak introns.

Nissen KE et al. Genes Dev 2017 Apr 01;31(7):688-701

PMID:11350031 - Mutation in the prp12+ gene encoding a homolog of SAP130/SF3b130 causes differential inhibition of pre-mRNA splicing and arrest of cell-cycle progression in Schizosaccharomyces pombe.

Habara Y et al. RNA 2001 May;7(5):671-81

PMID:9286671 - The prp1+ gene required for pre-mRNA splicing in Schizosaccharomyces pombe encodes a protein that contains TPR motifs and is similar to Prp6p of budding yeast.

Urushiyama S et al. Genetics 1997 Sep;147(1):101-15

PMID:11252721 - Fission yeast Prp4p kinase regulates pre-mRNA splicing by phosphorylating a non-SR-splicing factor.

Schwelnus W et al. EMBO Rep 2001 Jan;2(1):35-41

PMID:27298342 - Identification of S-phase DNA damage-response targets in fission yeast reveals conservation of damage-response networks.

Willis NA et al. Proc Natl Acad Sci U S A 2016 Jun 28;113(26):E3676-85

PMID:28947618 - Sde2 is an intron-specific pre-mRNA splicing regulator activated by ubiquitin-like processing.

Thakran P et al. EMBO J 2018 Jan 04;37(1):89-101

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:18257517 - Phosphoproteome analysis of fission yeast.

Wilson-Grady JT et al. J Proteome Res 2008 Mar;7(3):1088-97

PMID:18948543 - Splicing factors facilitate RNAi-directed silencing in fission yeast.

Bayne EH et al. Science 2008 Oct 24;322(5901):602-6

PMID:2034223 - prp4 from Schizosaccharomyces pombe, a mutant deficient in pre-mRNA splicing isolated using genes containing artificial introns.

Rosenberg GH et al. Mol Gen Genet 1991 Apr;226(1-2):305-9

PMID:24713849 - Post-transcriptional regulation of meiotic genes by a nuclear RNA silencing complex.

Egan ED et al. RNA 2014 Jun;20(6):867-81

PMID:26582768 - Abo1, a conserved bromodomain AAA-ATPase, maintains global nucleosome occupancy and organisation.

Gal C et al. EMBO Rep 2016 Jan;17(1):79-93

PMID:15755920 - Dim1p is required for efficient splicing and export of mRNA encoding lid1p, a component of the fission yeast anaphase-promoting complex.

Carnahan RH et al. Eukaryot Cell 2005 Mar;4(3):577-87

PMID:17450151 - Distinct roles of HDAC complexes in promoter silencing, antisense suppression and DNA damage protection.

Nicolas E et al. Nat Struct Mol Biol 2007 May;14(5):372-80

PMID:22990236 - Hrp3 controls nucleosome positioning to suppress non-coding transcription in eu- and heterochromatin.

Shim YS et al. EMBO J 2012 Nov 28;31(23):4375-87

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:22240020 - Characterization of the ptr5+ gene involved in nuclear mRNA export in fission yeast.

Watanabe N et al. Biochem Biophys Res Commun 2012 Feb 03;418(1):62-6

PMID:24014766 - Structural and functional characterization of the N terminus of Schizosaccharomyces pombe Cwf10.

Livesay SB et al. Eukaryot Cell 2013 Nov;12(11):1472-89

PMID:24081329 - Poly(A) tail-mediated gene regulation by opposing roles of Nab2 and Pab2 nuclear poly(A)-binding proteins in pre-mRNA decay.

Grenier St-Sauveur V et al. Mol Cell Biol 2013 Dec;33(23):4718-31