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protein coding gene - dld2 (SPBC713.03) - mitochondrial (R)-2-hydroxyglutarate dehydrogenase/ D-lactate dehydrogenase, cytochrome Dld2

Gene summary

Standard name
dld2
Systematic ID
SPBC713.03
Product
mitochondrial (R)-2-hydroxyglutarate dehydrogenase/ D-lactate dehydrogenase, cytochrome Dld2
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q9C1X2
ORFeome ID
49/49A09
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome II: 871202..873408 forward strand

Annotation

Disease association

MONDO:0024554 - D-2-hydroxyglutaric aciduria 1

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GO biological process

GO:1990748 - cellular detoxification

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GO:1903457 - lactate catabolic process

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GO cellular component

GO:0005759 - mitochondrial matrix

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GO:0005739 - mitochondrion

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GO molecular function

GO:0099615 - (R)-2-hydroxyglutarate-pyruvate transhydrogenase activity

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GO:0004458 - D-lactate dehydrogenase (cytochrome) activity

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GO:0071949 - FAD binding

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Protein sequence feature

SO:0001808 - mitochondrial_targeting_signal

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Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

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PomGeneEx:0000012 - RNA level decreased

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Quantitative gene expression

PBO:0006310 - protein level

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PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0000251 - decreased cell population growth on galactose carbon source

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Genotypes:

FYPO:0009094 - increased cell population growth on lysine and proline nitrogen source

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Genotypes:

FYPO:0009072 - increased cell population growth on lysine nitrogen source

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Genotypes:

FYPO:0001309 - increased viability in stationary phase

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Genotypes:

FYPO:0009031 - resistance to bleomycin

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Genotypes:

FYPO:0000067 - resistance to brefeldin A

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Genotypes:

FYPO:0002693 - resistance to diamide

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Genotypes:

FYPO:0009038 - resistance to egtazic acid

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Genotypes:

FYPO:0009070 - resistance to itraconazole

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Genotypes:

FYPO:0001583 - resistance to lithium

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Genotypes:

FYPO:0009087 - resistance to magnesium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0009043 - resistance to potassium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0003383 - resistance to tert-butyl hydroperoxide

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Genotypes:

FYPO:0001034 - resistance to tunicamycin

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Genotypes:

FYPO:0000785 - sensitive to formamide

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Genotypes:

FYPO:0001234 - slow vegetative cell population growth

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

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Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF01565FAD_binding_4Oxid_FAD_bind_NPfam
PF02913FAD-oxidase_CFAD-bd_oxidored_4_CPfam
PS51387FAD_PCMHFAD-bd_PCMHPROSITE profiles
G3DSA:1.10.45.10:FF:000001CATH-FunFam
G3DSA:3.30.43.10:FF:000002CATH-FunFam
G3DSA:3.30.465.10:FF:000001CATH-FunFam
G3DSA:3.30.70.2190:FF:000001CATH-FunFam
G3DSA:3.30.70.2740:FF:000002CATH-FunFam
G3DSA:1.10.45.10Vanillyl_alc_oxidase_C-sub2CATH-Gene3D
G3DSA:3.30.43.10FAD-bd_PCMH_sub1CATH-Gene3D
G3DSA:3.30.465.10FAD-bd_PCMH_sub2CATH-Gene3D
G3DSA:3.30.70.2190CATH-Gene3D
G3DSA:3.30.70.2740CATH-Gene3D
SSF55103FAD-linked_Oxase-like_CSUPERFAMILY
SSF56176FAD-bd_PCMH-like_sfSUPERFAMILY
PTHR43716FAD-oxidored/transferase_4PANTHER

Orthologs

References / Literature

GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
PMID:25452419 - Parallel profiling of fission yeast deletion mutants for proliferation and for lifespan during long-term quiescence.
Sideri T et al. G3 (Bethesda) 2014 Dec 01;5(1):145-55
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
GO_REF:0000002 - Comments
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:22540037 - Predicting the fission yeast protein interaction network.
Pancaldi V et al. G3 (Bethesda) 2012 Apr;2(4):453-67
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:35820914 - Antagonistic effects of mitochondrial matrix and intermembrane space proteases on yeast aging.
Vega M et al. BMC Biol 2022 Jul 12;20(1):160
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105