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protein coding gene - adl1 (SPBC713.06) - DNA ligase

Gene summary

Standard name
adl1
Systematic ID
SPBC713.06
Product
DNA ligase
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
lig3
UniProt ID
Q9C1W9
ORFeome ID
49/49E03
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome II: 877504..882319 forward strand

Annotation

Disease association

MONDO:0030693 - immunodeficiency 96

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GO biological process

GO:0071897 - DNA biosynthetic process

References:

GO:0006310 - DNA recombination

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GO:0006281 - DNA repair

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GO:0006273 - lagging strand elongation

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GO cellular component

GO:0005634 - nucleus

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GO molecular function

GO:0005524 - ATP binding

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GO:0003677 - DNA binding

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GO:0003910 - DNA ligase (ATP) activity

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Modification

MOD:00046 - O-phospho-L-serine

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MOD:00047 - O-phospho-L-threonine

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MOD:00048 - O4'-phospho-L-tyrosine

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Qualitative gene expression

PomGeneEx:0000011 - RNA level increased

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Quantitative gene expression

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0009094 - increased cell population growth on lysine and proline nitrogen source

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Genotypes:

FYPO:0009072 - increased cell population growth on lysine nitrogen source

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Genotypes:

FYPO:0006518 - loss of viability in G0

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Genotypes:

FYPO:0007553 - normal G1 to G0 transition

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Genotypes:

FYPO:0000067 - resistance to brefeldin A

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Genotypes:

FYPO:0000763 - resistance to cadmium

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Genotypes:

FYPO:0002693 - resistance to diamide

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Genotypes:

FYPO:0002578 - resistance to hydroxyurea

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Genotypes:

FYPO:0009085 - resistance to lithium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0009087 - resistance to magnesium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0009039 - resistance to potassium chloride

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Genotypes:

FYPO:0002767 - resistance to terbinafine

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Genotypes:

FYPO:0003383 - resistance to tert-butyl hydroperoxide

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Genotypes:

FYPO:0007808 - resistance to valproic acid

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Genotypes:

FYPO:0000830 - resistance to vanadate

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

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Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0009798 - faster evolving duplicate

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF04675DNA_ligase_A_NDNA_ligase_ATP-dep_NPFAM
PF01068DNA_ligase_A_MDNA_ligase_ATP-dep_centPFAM
PF04679DNA_ligase_A_CDNA_ligase_ATP-dep_CPFAM
cd07969OBF_DNA_ligase_ICDD
cd07900Adenylation_DNA_ligase_I_EukCDD
PS00697DNA_LIGASE_A1DNA_ligase_ATP-dep_CSPROSITE_PATTERNS
PS50160DNA_LIGASE_A3DNA_ligase_ATP-dep_centPROSITE_PROFILES
G3DSA:3.30.470.30:FF:000002FUNFAM
G3DSA:2.40.50.140:FF:000062FUNFAM
SSF117018ATP-dependent DNA ligase DNA-binding domainDNA_ligase_N_sfSUPERFAMILY
SSF56091DNA ligase/mRNA capping enzyme, catalytic domainSUPERFAMILY
SSF50249Nucleic acid-binding proteinsNA-bd_OB-foldSUPERFAMILY
G3DSA:2.40.50.140NA-bd_OB-foldGENE3D
G3DSA:1.10.3260.10DNA_ligase_N_sfGENE3D
G3DSA:3.30.470.30DNA ligase/mRNA capping enzymeGENE3D
G3DSA:3.30.1490.70GENE3D
PTHR45674DNA LIGASE 1/3 FAMILY MEMBERATP-dep_DNA_ligasePANTHER
mobidb-lite-Disorderdisorder_predictionMOBIDB-Disorder
TIGR00574dnl1DNA_ligase_ATP-depNCBIFAM

Orthologs

References / Literature

PMID:33260998 - High-Throughput Flow Cytometry Combined with Genetic Analysis Brings New Insights into the Understanding of Chromatin Regulation of Cellular Quiescence.
Zahedi Y et al. Int J Mol Sci 2020 Nov 27;21(23)
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.
Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101
GO_REF:0000002 - Comments
GO_REF:0000033 - Annotation inferences using phylogenetic trees
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053