protein coding gene - res1 (SPBC725.16) - MBF transcription factor complex subunit Res1

Gene summary

Standard name

res1

Systematic ID

SPBC725.16

Product

MBF transcription factor complex subunit Res1

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

sct1

UniProt ID

P33520

ORFeome ID

40/40G10

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome II: 1232586..1235587 forward strand

Annotation

Protein features

Orthologs

• res1 (SJAG_00693) Schizosaccharomyces japonicus
• SWI4 (YER111C) Saccharomyces cerevisiae

References / Literature

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:24006488 - The DNA damage and the DNA replication checkpoints converge at the MBF transcription factor.

Ivanova T et al. Mol Biol Cell 2013 Nov;24(21):3350-7

PMID:17936710 - Ctp1 is a cell-cycle-regulated protein that functions with Mre11 complex to control double-strand break repair by homologous recombination.

Limbo O et al. Mol Cell 2007 Oct 12;28(1):134-46

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704

PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.

Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514

PMID:39476757 - Characterization of Ksg1 protein kinase-dependent phosphoproteome in the fission yeast S. pombe.

Cipak L et al. Biochem Biophys Res Commun 2024 Oct 25;736:150895

PMID:26890608 - A functional genome-wide genetic screening identifies new pathways controlling the G1/S transcriptional wave.

Gaspa L et al. Cell Cycle 2016;15(5):720-9

PMID:19714215 - The fission yeast homeodomain protein Yox1p binds to MBF and confines MBF-dependent cell-cycle transcription to G1-S via negative feedback.

Aligianni S et al. PLoS Genet 2009 Aug;5(8):e1000626

PMID:18257517 - Phosphoproteome analysis of fission yeast.

Wilson-Grady JT et al. J Proteome Res 2008 Mar;7(3):1088-97

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:21132016 - Yox1 links MBF-dependent transcription to completion of DNA synthesis.

Gómez-Escoda B et al. EMBO Rep 2011 Jan;12(1):84-9

PMID:26912660 - Gad8 Protein Is Found in the Nucleus Where It Interacts with the MluI Cell Cycle Box-binding Factor (MBF) Transcriptional Complex to Regulate the Response to DNA Replication Stress.

Cohen A et al. J Biol Chem 2016 Apr 22;291(17):9371-81

PMID:9614195 - Functional domains of rep2, a transcriptional activator subunit for Res2-Cdc10, controlling the cell cycle "start".

Tahara S et al. Mol Biol Cell 1998 Jun;9(6):1577-88

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:19547744 - Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Beltrao P et al. PLoS Biol 2009 Jun 16;7(6):e1000134

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:30134042 - The INO80 complex activates the transcription of S-phase genes in a cell cycle-regulated manner.

Knezevic I et al. FEBS J 2018 Oct;285(20):3870-3881

PMID:1522142 - Cytoskeletal and DNA structure abnormalities result from bypass of requirement for the cdc10 start gene in the fission yeast Schizosaccharomyces pombe.

Marks J et al. J Cell Sci 1992 Mar;101 ( Pt 3):517-28

PMID:14648198 - DSC1-MCB regulation of meiotic transcription in Schizosaccharomyces pombe.

Cunliffe L et al. Mol Genet Genomics 2004 Feb;271(1):60-71

PMID:11029045 - A role for the START gene-specific transcription factor complex in the inactivation of cyclin B and Cut2 destruction.

Tournier S et al. Mol Biol Cell 2000 Oct;11(10):3411-24

PMID:10564266 - Cell cycle-regulated transcription in fission yeast: Cdc10-Res protein interactions during the cell cycle and domains required for regulated transcription.

Whitehall S et al. Mol Biol Cell 1999 Nov;10(11):3705-15

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.

Skribbe M et al. Mol Cell 2025 Feb 19;

PMID:7588609 - Fission yeast Rep2 is a putative transcriptional activator subunit for the cell cycle 'start' function of Res2-Cdc10.

Nakashima N et al. EMBO J 1995 Oct 02;14(19):4794-802

PMID:1464317 - A new cdc gene required for S phase entry of Schizosaccharomyces pombe encodes a protein similar to the cdc 10+ and SWI4 gene products.

Tanaka K et al. EMBO J 1992 Dec;11(13):4923-32

PMID:7739540 - The Schizosaccharomyces pombe MBF complex requires heterodimerization for entry into S phase.

Ayté J et al. Mol Cell Biol 1995 May;15(5):2589-99

PMID:25533348 - Tolerance of deregulated G1/S transcription depends on critical G1/S regulon genes to prevent catastrophic genome instability.

Caetano C et al. Cell Rep 2014 Dec 24;9(6):2279-89

PMID:30824696 - Systematic analysis reveals the prevalence and principles of bypassable gene essentiality.

Li J et al. Nat Commun 2019 Mar 01;10(1):1002

PMID:8168486 - A zinc finger protein controls the onset of premeiotic DNA synthesis of fission yeast in a Mei2-independent cascade.

Sugiyama A et al. EMBO J 1994 Apr 15;13(8):1881-7

PMID:9201720 - Ran1 functions to control the Cdc10/Sct1 complex through Puc1.

Caligiuri M et al. Mol Biol Cell 1997 Jun;8(6):1117-28

PMID:26730850 - Prp4 Kinase Grants the License to Splice: Control of Weak Splice Sites during Spliceosome Activation.

Eckert D et al. PLoS Genet 2016 Jan;12(1):e1005768

PMID:9034336 - Fission yeast pheromone blocks S-phase by inhibiting the G1 cyclin B-p34cdc2 kinase.

Stern B et al. EMBO J 1997 Feb 03;16(3):534-44

PMID:7916653 - Sct1 functions in partnership with Cdc10 in a transcription complex that activates cell cycle START and inhibits differentiation.

Caligiuri M et al. Cell 1993 Feb 26;72(4):607-19

PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

Halova L et al. Open Biol 2021 Apr;11(4):200405

PMID:9118941 - Functional characterization of the fission yeast Start-specific transcription factor Res2.

Zhu Y et al. EMBO J 1997 Mar 03;16(5):1023-34

PMID:23695302 - Functional characterization of fission yeast transcription factors by overexpression analysis.

Vachon L et al. Genetics 2013 Aug;194(4):873-84

PMID:28903048 - Set2 Methyltransferase Facilitates DNA Replication and Promotes Genotoxic Stress Responses through MBF-Dependent Transcription.

Pai CC et al. Cell Rep 2017 Sep 12;20(11):2693-2705

PMID:8970158 - Domains determining the functional distinction of the fission yeast cell cycle "start" molecules Res1 and Res2.

Sturm S et al. Mol Biol Cell 1996 Dec;7(12):1967-76

PMID:11389847 - Transcriptional termination factors for RNA polymerase II in yeast.

Aranda A et al. Mol Cell 2001 May;7(5):1003-11

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.

Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87

PMID:7909513 - A B-type cyclin negatively regulates conjugation via interacting with cell cycle 'start' genes in fission yeast.

Obara-Ishihara T et al. EMBO J 1994 Apr 15;13(8):1863-72

PMID:11781565 - Feedback regulation of the MBF transcription factor by cyclin Cig2.

Ayté J et al. Nat Cell Biol 2001 Dec;3(12):1043-50

PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.

Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6

PMID:8223442 - The activity of S.pombe DSC-1-like factor is cell cycle regulated and dependent on the activity of p34cdc2.

Reymond A et al. EMBO J 1993 Nov;12(11):4325-34

PMID:9755169 - Cdc18 transcription and proteolysis couple S phase to passage through mitosis.

Baum B et al. EMBO J 1998 Oct 01;17(19):5689-98

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:23297348 - Comprehensive proteomics analysis reveals new substrates and regulators of the fission yeast clp1/cdc14 phosphatase.

Chen JS et al. Mol Cell Proteomics 2013 May;12(5):1074-86

PMID:8168485 - res2+, a new member of the cdc10+/SWI4 family, controls the 'start' of mitotic and meiotic cycles in fission yeast.

Miyamoto M et al. EMBO J 1994 Apr 15;13(8):1873-80

PMID:9303312 - Control of S-phase periodic transcription in the fission yeast mitotic cycle.

Baum B et al. EMBO J 1997 Aug 01;16(15):4676-88