protein coding gene - dis2 (SPBC776.02c) - serine/threonine protein phosphatase PP1 catalytic subunit Dis2

Gene summary

Standard name

dis2

Systematic ID

SPBC776.02c

Product

serine/threonine protein phosphatase PP1 catalytic subunit Dis2

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

sds1, bws1

UniProt ID

P13681

ORFeome ID

40/40E03

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome II: 3173165..3175098 reverse strand

Annotation

Protein features

Orthologs

• PPP1CA (HGNC:9281) Homo sapiens
• PPP1CB (HGNC:9282) Homo sapiens
• PPP1CC (HGNC:9283) Homo sapiens
• dis2 (SJAG_03126) Schizosaccharomyces japonicus
• GLC7 (YER133W) Saccharomyces cerevisiae

References / Literature

PMID:35012333 - Cleavage-Polyadenylation Factor Cft1 and SPX Domain Proteins Are Agents of Inositol Pyrophosphate Toxicosis in Fission Yeast.

Schwer B et al. mBio 2022 Feb 22;13(1):e0347621

PMID:36882296 - Duf89 abets lncRNA control of fission yeast phosphate homeostasis via its antagonism of precocious lncRNA transcription termination.

Sanchez AM et al. RNA 2023 Jun;29(6):808-825

PMID:39156640 - Fission yeast Bgs1 glucan synthase participates in the control of growth polarity and membrane traffic.

Ramos M et al. iScience 2024 Aug 16;27(8):110477

PMID:8387356 - Isolation and characterization of the fission yeast protein phosphatase gene ppe1+ involved in cell shape control and mitosis.

Shimanuki M et al. Mol Biol Cell 1993 Mar;4(3):303-13

PMID:7957097 - Phosphorylation of dis2 protein phosphatase at the C-terminal cdc2 consensus and its potential role in cell cycle regulation.

Yamano H et al. EMBO J 1994 Nov 15;13(22):5310-8

PMID:8978689 - Requirement for PP1 phosphatase and 20S cyclosome/APC for the onset of anaphase is lessened by the dosage increase of a novel gene sds23+.

Ishii K et al. EMBO J 1996 Dec 02;15(23):6629-40

PMID:10545451 - spp42, identified as a classical suppressor of prp4-73, which encodes a kinase involved in pre-mRNA splicing in fission yeast, is a homologue of the splicing factor Prp8p.

Schmidt H et al. Genetics 1999 Nov;153(3):1183-91

PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.

Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31

PMID:22521786 - Phosphodependent recruitment of Bub1 and Bub3 to Spc7/KNL1 by Mph1 kinase maintains the spindle checkpoint.

Shepperd LA et al. Curr Biol 2012 May 22;22(10):891-9

PMID:29852001 - New insights into donor directionality of mating-type switching in Schizosaccharomyces pombe.

Maki T et al. PLoS Genet 2018 May;14(5):e1007424

PMID:22375062 - Plo1 phosphorylates Dam1 to promote chromosome bi-orientation in fission yeast.

Buttrick GJ et al. J Cell Sci 2012 Apr 01;125(Pt 7):1645-51

PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.

Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323

PMID:2170029 - Distinct, essential roles of type 1 and 2A protein phosphatases in the control of the fission yeast cell division cycle.

Kinoshita N et al. Cell 1990 Oct 19;63(2):405-15

PMID:14617822 - A comparative analysis of an orthologous proteomic environment in the yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe.

Roguev A et al. Mol Cell Proteomics 2004 Feb;3(2):125-32

PMID:30355770 - RNA polymerase II CTD interactome with 3' processing and termination factors in fission yeast and its impact on phosphate homeostasis.

Sanchez AM et al. Proc Natl Acad Sci U S A 2018 Nov 06;115(45):E10652-E10661

PMID:22065639 - Cdk1 phosphorylation of the kinetochore protein Nsk1 prevents error-prone chromosome segregation.

Chen JS et al. J Cell Biol 2011 Nov 14;195(4):583-93

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:21703453 - A phosphorylation cycle shapes gradients of the DYRK family kinase Pom1 at the plasma membrane.

Hachet O et al. Cell 2011 Jun 24;145(7):1116-28

PMID:31276588 - Inositol pyrophosphates impact phosphate homeostasis via modulation of RNA 3' processing and transcription termination.

Sanchez AM et al. Nucleic Acids Res 2019 Sep 19;47(16):8452-8469

PMID:36006032 - Analysis of the potential role of fission yeast PP2A in spindle assembly checkpoint inactivation.

Deng DJ et al. FASEB J 2022 Sep;36(9):e22524

PMID:9264466 - Distinct subunit functions and cell cycle regulated phosphorylation of 20S APC/cyclosome required for anaphase in fission yeast.

Yamada H et al. J Cell Sci 1997 Aug;110 ( Pt 15):1793-804

PMID:25764183 - Condensin HEAT subunits required for DNA repair, kinetochore/centromere function and ploidy maintenance in fission yeast.

Xu X et al. PLoS One 2015;10(3):e0119347

PMID:21965289 - Nsk1 ensures accurate chromosome segregation by promoting association of kinetochores to spindle poles during anaphase B.

Buttrick GJ et al. Mol Biol Cell 2011 Dec;22(23):4486-502

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:32282918 - Genetic interactions and transcriptomics implicate fission yeast CTD prolyl isomerase Pin1 as an agent of RNA 3' processing and transcription termination that functions via its effects on CTD phosphatase Ssu72.

Sanchez AM et al. Nucleic Acids Res 2020 May 21;48(9):4811-4826

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:16688222 - Histone H2B mutations in inner region affect ubiquitination, centromere function, silencing and chromosome segregation.

Maruyama T et al. EMBO J 2006 Jun 07;25(11):2420-31

PMID:33260998 - High-Throughput Flow Cytometry Combined with Genetic Analysis Brings New Insights into the Understanding of Chromatin Regulation of Cellular Quiescence.

Zahedi Y et al. Int J Mol Sci 2020 Nov 27;21(23)

PMID:31269446 - CPF Recruitment to Non-canonical Transcription Termination Sites Triggers Heterochromatin Assembly and Gene Silencing.

Vo TV et al. Cell Rep 2019 Jul 02;28(1):267-281.e5

PMID:15335873 - Mitotic regulation of protein phosphatases by the fission yeast sds22 protein.

Stone EM et al. Curr Biol 1993 Jan;3(1):13-26

PMID:30282034 - Elongation/Termination Factor Exchange Mediated by PP1 Phosphatase Orchestrates Transcription Termination.

Kecman T et al. Cell Rep 2018 Oct 02;25(1):259-269.e5

PMID:34967420 - Genetic screen for suppression of transcriptional interference reveals fission yeast 14-3-3 protein Rad24 as an antagonist of precocious Pol2 transcription termination.

Garg A et al. Nucleic Acids Res 2022 Jan 25;50(2):803-819

PMID:9200612 - tea1 and the microtubular cytoskeleton are important for generating global spatial order within the fission yeast cell.

Mata J et al. Cell 1997 Jun 13;89(6):939-49

PMID:2544292 - Involvement of a type 1 protein phosphatase encoded by bws1+ in fission yeast mitotic control.

Booher R et al. Cell 1989 Jun 16;57(6):1009-16

PMID:7628693 - p93dis1, which is required for sister chromatid separation, is a novel microtubule and spindle pole body-associating protein phosphorylated at the Cdc2 target sites.

Nabeshima K et al. Genes Dev 1995 Jul 01;9(13):1572-85

PMID:29899453 - A Cdk9-PP1 switch regulates the elongation-termination transition of RNA polymerase II.

Parua PK et al. Nature 2018 Jun;558(7710):460-464

PMID:3409871 - Cold-sensitive and caffeine-supersensitive mutants of the Schizosaccharomyces pombe dis genes implicated in sister chromatid separation during mitosis.

Ohkura H et al. EMBO J 1988 May;7(5):1465-73

PMID:28041796 - A PP2A-B55-Mediated Crosstalk between TORC1 and TORC2 Regulates the Differentiation Response in Fission Yeast.

Martín R et al. Curr Biol 2017 Jan 23;27(2):175-188

PMID:2245912 - stf1: non-wee mutations epistatic to cdc25 in the fission yeast Schizosaccharomyces pombe.

Hudson JD et al. Genetics 1990 Oct;126(2):309-15

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:34389684 - Genetic screen for suppression of transcriptional interference identifies a gain-of-function mutation in Pol2 termination factor Seb1.

Schwer B et al. Proc Natl Acad Sci U S A 2021 Aug 17;118(33)

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:21664573 - Spindle checkpoint silencing requires association of PP1 to both Spc7 and kinesin-8 motors.

Meadows JC et al. Dev Cell 2011 Jun 14;20(6):739-50

PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.

Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160

PMID:9339378 - Genomic organization and functional analysis of the murine protein phosphatase 1c gamma (Ppp1cc) gene.

Okano K et al. Genomics 1997 Oct 01;45(1):211-5

PMID:26525038 - Casein kinase 1γ acts as a molecular switch for cell polarization through phosphorylation of the polarity factor Tea1 in fission yeast.

Koyano T et al. Genes Cells 2015 Dec;20(12):1046-58

PMID:11084332 - Cut8, essential for anaphase, controls localization of 26S proteasome, facilitating destruction of cyclin and Cut2.

Tatebe H et al. Curr Biol 2000 Nov 02;10(21):1329-38

PMID:23333317 - Removal of centrosomal PP1 by NIMA kinase unlocks the MPF feedback loop to promote mitotic commitment in S. pombe.

Grallert A et al. Curr Biol 2013 Feb 04;23(3):213-22

PMID:7983142 - A calcineurin-like gene ppb1+ in fission yeast: mutant defects in cytokinesis, cell polarity, mating and spindle pole body positioning.

Yoshida T et al. J Cell Sci 1994 Jul;107 ( Pt 7):1725-35

PMID:10582241 - Control of metaphase-anaphase progression by proteolysis: cyclosome function regulated by the protein kinase A pathway, ubiquitination and localization.

Yanagida M et al. Philos Trans R Soc Lond B Biol Sci 1999 Sep 29;354(1389):1559-69; discussion 1569-70

GO_REF:0000108 - Automatic assignment of GO terms using logical inference, based on on inter-ontology links.

PMID:2544298 - The fission yeast dis2+ gene required for chromosome disjoining encodes one of two putative type 1 protein phosphatases.

Ohkura H et al. Cell 1989 Jun 16;57(6):997-1007

PMID:14765108 - Recovery from DNA damage checkpoint arrest by PP1-mediated inhibition of Chk1.

den Elzen NR et al. EMBO J 2004 Feb 25;23(4):908-18

PMID:2561424 - Gene products required for chromosome separation.

Yanagida M J Cell Sci Suppl 1989;12:213-29

PMID:24713849 - Post-transcriptional regulation of meiotic genes by a nuclear RNA silencing complex.

Egan ED et al. RNA 2014 Jun;20(6):867-81

PMID:34133210 - Cdk1 phosphorylation of fission yeast paxillin inhibits its cytokinetic ring localization.

Mangione MC et al. Mol Biol Cell 2021 Aug 15;32(17):1534-1544

PMID:38971312 - TORC2 is required for accumulation of γH2A in response to DNA damage.

Cohen A et al. J Biol Chem 2024 Jul 04;:107531

PMID:24554432 - The Tea4-PP1 landmark promotes local growth by dual Cdc42 GEF recruitment and GAP exclusion.

Kokkoris K et al. J Cell Sci 2014 May 01;127(Pt 9):2005-16

PMID:28180297 - Fission yeast Stn1 is crucial for semi-conservative replication at telomeres and subtelomeres.

Takikawa M et al. Nucleic Acids Res 2017 Feb 17;45(3):1255-1269

PMID:24656819 - Protein phosphatase 1 recruitment by Rif1 regulates DNA replication origin firing by counteracting DDK activity.

Davé A et al. Cell Rep 2014 Apr 10;7(1):53-61

PMID:28974540 - The fission yeast nucleoporin Alm1 is required for proteasomal degradation of kinetochore components.

Salas-Pino S et al. J Cell Biol 2017 Nov 06;216(11):3591-3608

GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference

PMID:32361273 - Requirement of PP2A-B56 Par1 for the Stabilization of the CDK Inhibitor Rum1 and Activation of APC/C Ste9 during Pre-Start G1 in S. pombe.

Stonyte V et al. iScience 2020 May 22;23(5):101063

PMID:37772819 - Activities, substrate specificity, and genetic interactions of fission yeast Siw14, a cysteinyl-phosphatase-type inositol pyrophosphatase.

Sanchez AM et al. mBio 2023 Sep 29;14(5):e0205623

PMID:1944266 - The fission yeast dis3+ gene encodes a 110-kDa essential protein implicated in mitotic control.

Kinoshita N et al. Mol Cell Biol 1991 Dec;11(12):5839-47

PMID:8389306 - Negative regulation of mitosis by the fission yeast protein phosphatase ppa2.

Kinoshita N et al. Genes Dev 1993 Jun;7(6):1059-71

PMID:16079915 - The DASH complex and Klp5/Klp6 kinesin coordinate bipolar chromosome attachment in fission yeast.

Sanchez-Perez I et al. EMBO J 2005 Aug 17;24(16):2931-43

PMID:25472718 - Alp7/TACC recruits kinesin-8-PP1 to the Ndc80 kinetochore protein for timely mitotic progression and chromosome movement.

Tang NH et al. J Cell Sci 2015 Jan 15;128(2):354-63

PMID:23163955 - Analysis of stress-induced duplex destabilization (SIDD) properties of replication origins, genes and intergenes in the fission yeast, Schizosaccharomyces pombe.

Yadav MP et al. BMC Res Notes 2012 Nov 19;5:643

PMID:27618268 - Bub3-Bub1 Binding to Spc7/KNL1 Toggles the Spindle Checkpoint Switch by Licensing the Interaction of Bub1 with Mad1-Mad2.

Mora-Santos MD et al. Curr Biol 2016 Oct 10;26(19):2642-2650

PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.

Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514

PMID:33579781 - Transcriptional profiling of fission yeast RNA polymerase II CTD mutants.

Garg A et al. RNA 2021 Feb 12;27(5):560-70

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

Halova L et al. Open Biol 2021 Apr;11(4):200405

PMID:1846086 - S. pombe gene sds22+ essential for a midmitotic transition encodes a leucine-rich repeat protein that positively modulates protein phosphatase-1.

Ohkura H et al. Cell 1991 Jan 11;64(1):149-57

PMID:19592249 - A novel protein phosphatase 1-dependent spindle checkpoint silencing mechanism.

Vanoosthuyse V et al. Curr Biol 2009 Jul 28;19(14):1176-81

PMID:23297348 - Comprehensive proteomics analysis reveals new substrates and regulators of the fission yeast clp1/cdc14 phosphatase.

Chen JS et al. Mol Cell Proteomics 2013 May;12(5):1074-86

PMID:10947840 - Mis3 with a conserved RNA binding motif is essential for ribosome biogenesis and implicated in the start of cell growth and S phase checkpoint.

Kondoh H et al. Genes Cells 2000 Jul;5(7):525-41

PMID:12376568 - An evolutionarily conserved fission yeast protein, Ned1, implicated in normal nuclear morphology and chromosome stability, interacts with Dis3, Pim1/RCC1 and an essential nucleoporin.

Tange Y et al. J Cell Sci 2002 Nov 15;115(Pt 22):4375-85

PMID:16920624 - CDC2 phosphorylation of the fission yeast dis1 ensures accurate chromosome segregation.

Aoki K et al. Curr Biol 2006 Aug 22;16(16):1627-35

PMID:23438755 - A chemical biology strategy to analyze rheostat-like protein kinase-dependent regulation.

Kawashima SA et al. Chem Biol 2013 Feb 21;20(2):262-71

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:25487150 - A PP1-PP2A phosphatase relay controls mitotic progression.

Grallert A et al. Nature 2015 Jan 01;517(7532):94-98

PMID:28218250 - Chromatin remodeller Fun30 Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Lee J et al. Nat Commun 2017 Feb 20;8:14527

PMID:17895368 - Schizosaccharomyces pombe protein phosphatase 1 in mitosis, endocytosis and a partnership with Wsh3/Tea4 to control polarised growth.

Alvarez-Tabarés I et al. J Cell Sci 2007 Oct 15;120(Pt 20):3589-601

PMID:24945319 - CPF-associated phosphatase activity opposes condensin-mediated chromosome condensation.

Vanoosthuyse V et al. PLoS Genet 2014 Jun;10(6):e1004415

PMID:33010152 - A genetic screen for suppressors of hyper-repression of the fission yeast PHO regulon by Pol2 CTD mutation T4A implicates inositol 1-pyrophosphates as agonists of precocious lncRNA transcription termination.

Garg A et al. Nucleic Acids Res 2020 Nov 04;48(19):10739-10752

PMID:32546512 - Inactivation of fission yeast Erh1 de-represses pho1 expression: evidence that Erh1 is a negative regulator of prt lncRNA termination.

Schwer B et al. RNA 2020 Oct;26(10):1334-1344

PMID:33711009 - Structure-function analysis of fission yeast cleavage and polyadenylation factor (CPF) subunit Ppn1 and its interactions with Dis2 and Swd22.

Benjamin B et al. PLoS Genet 2021 Mar;17(3):e1009452