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protein coding gene - sec2302 (SPBC776.04) - COPII vesicle coat, GAP for Sar1, Sec23b

Gene summary

Standard name
sec2302
Systematic ID
SPBC776.04
Product
COPII vesicle coat, GAP for Sar1, Sec23b
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
sec23-b
UniProt ID
O94672
ORFeome ID
29/29D04
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 3178553..3181338 forward strand

Annotation

Disease association

MONDO:0009134 - congenital dyserythropoietic anemia type 2

References:

MONDO:0014802 - Cowden syndrome 7

References:

MONDO:0011911 - craniolenticulosutural dysplasia

References:

GO biological process

GO:0090110 - COPII-coated vesicle cargo loading

References:

GO:0006886 - intracellular protein transport

References:

GO cellular component

GO:0030127 - COPII vesicle coat

References:

GO:0005829 - cytosol

References:

GO:0070971 - endoplasmic reticulum exit site

References:

GO:0005634 - nucleus

References:

GO molecular function

GO:0005096 - GTPase activator activity

References:

GO:0008270 - zinc ion binding

References:

Modification

MOD:00046 - O-phospho-L-serine

References:

MOD:01148 - ubiquitinylated lysine

References:

Qualitative gene expression

PomGeneEx:0000011 - RNA level increased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0000708 - decreased mating efficiency

References:

Genotypes:

FYPO:0005261 - increased cell population growth on galactose carbon source

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0001986 - resistance to 5-fluorouracil

References:

Genotypes:

FYPO:0009031 - resistance to bleomycin

References:

Genotypes:

FYPO:0002634 - resistance to cobalt

References:

Genotypes:

FYPO:0000764 - resistance to cycloheximide

References:

Genotypes:

FYPO:0009038 - resistance to egtazic acid

References:

Genotypes:

FYPO:0001583 - resistance to lithium

References:

Genotypes:

FYPO:0009083 - resistance to lithium chloride and methyl methanesulfonate

References:

Genotypes:

FYPO:0009039 - resistance to potassium chloride

References:

Genotypes:

FYPO:0000830 - resistance to vanadate

References:

Genotypes:

FYPO:0000085 - sensitive to camptothecin

References:

Genotypes:

FYPO:0001492 - viable elongated vegetative cell

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002197 - viable vegetative cell with abnormal cell shape

References:

Genotypes:

FYPO:0001510 - viable vegetative cell, abnormal cell shape, normal cell size

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

Protein features

IDNameInterPro nameDB name
PF00626GelsolinGelsolin-like_domPfam
PF04810zf-Sec23_Sec24Znf_Sec23_Sec24Pfam
PF04811Sec23_trunkSec23/24_trunk_domPfam
PF04815Sec23_helicalSec23/24_helical_domPfam
PF08033Sec23_BSBeta-sandwich_Sec23_24Pfam
cd01478Sec23-likeCDD
cd11287Sec23_CSec23_CCDD
G3DSA:1.20.120.730:FF:000005CATH-FunFam
G3DSA:2.30.30.380:FF:000001CATH-FunFam
G3DSA:3.40.20.10:FF:000006CATH-FunFam
G3DSA:3.40.50.410:FF:000008CATH-FunFam
G3DSA:1.20.120.730CATH-Gene3D
G3DSA:2.30.30.380CATH-Gene3D
G3DSA:2.60.40.1670CATH-Gene3D
G3DSA:3.40.20.10ADF-H/Gelsolin-like_dom_sfCATH-Gene3D
G3DSA:3.40.50.410vWFA_dom_sfCATH-Gene3D
SSF53300vWFA_dom_sfSUPERFAMILY
SSF81811Sec23/24_helical_dom_sfSUPERFAMILY
SSF81995SUPERFAMILY
SSF82754Gelsolin-like_dom_sfSUPERFAMILY
SSF82919Znf_Sec23_Sec24_sfSUPERFAMILY
PTHR11141Sec23PANTHER

Orthologs

References / Literature

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:25373780 - A genomic Multiprocess survey of machineries that control and link cell shape, microtubule organization, and cell-cycle progression.
Graml V et al. Dev Cell 2014 Oct 27;31(2):227-239
PMID:22806344 - Genome-wide screen reveals novel mechanisms for regulating cobalt uptake and detoxification in fission yeast.
Ryuko S et al. Mol Genet Genomics 2012 Aug;287(8):651-62
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:18257517 - Phosphoproteome analysis of fission yeast.
Wilson-Grady JT et al. J Proteome Res 2008 Mar;7(3):1088-97
PMID:20537132 - Global fitness profiling of fission yeast deletion strains by barcode sequencing.
Han TX et al. Genome Biol 2010;11(6):R60
PMID:21340088 - Microarray-based target identification using drug hypersensitive fission yeast expressing ORFeome.
Arita Y et al. Mol Biosyst 2011 May;7(5):1463-72
PMID:23950735 - Global analysis of fission yeast mating genes reveals new autophagy factors.
Sun LL et al. PLoS Genet 2013;9(8):e1003715
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.
Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.
Mata J et al. Nat Genet 2002 Sep;32(1):143-7
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:27255861 - Genetic evidence for involvement of membrane trafficking in the action of 5-fluorouracil.
Hu L et al. Fungal Genet Biol 2016 Aug;93:17-24
PMID:28410370 - A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.
Dudin O et al. PLoS Genet 2017 Apr;13(4):e1006721
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
GO_REF:0000002 - Comments
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)