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protein coding gene - ste13 (SPBC776.09) - ATP-dependent RNA helicase Ste13/Dhh1

Gene summary

Standard name
ste13
Systematic ID
SPBC776.09
Product
ATP-dependent RNA helicase Ste13/Dhh1
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
dhh1
UniProt ID
Q09181
ORFeome ID
33/33B08
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 3191317..3193807 forward strand

Annotation

Complementation

PBO:0015694 - functionally complemented by D. melanogaster ME31B

References:

Disease association

MONDO:0032851 - intellectual developmental disorder with impaired language and dysmorphic facies

References:

GO biological process

GO:0000290 - deadenylation-dependent decapping of nuclear-transcribed mRNA

References:

GO:0033962 - P-body assembly

References:

GO:0034063 - stress granule assembly

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GO cellular component

GO:0005737 - cytoplasm

References:

GO:0010494 - cytoplasmic stress granule

References:

GO:0000932 - P-body

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GO molecular function

GO:0005524 - ATP binding

References:

GO:0003729 - mRNA binding

References:

GO:0003724 - RNA helicase activity

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Modification

MOD:00046 - O-phospho-L-serine

References:

MOD:00047 - O-phospho-L-threonine

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MOD:01149 - sumoylated lysine

References:

MOD:01148 - ubiquitinylated lysine

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Multi-locus phenotype

FYPO:0003612 - viable spore population

References:

Genotypes:

Protein features

PBO:0111747 - DEAD/DEAH box helicase

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

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PomGeneEx:0000014 - RNA present

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Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0003345 - abolished cell cycle arrest in mitotic G1 phase in response to nitrogen starvation

References:

Genotypes:

FYPO:0000474 - abolished meiosis

References:

Genotypes:

FYPO:0000684 - decreased cell population growth on glycerol carbon source

References:

Genotypes:

FYPO:0006541 - decreased protein level during mating

References:

Genotypes:

FYPO:0001897 - P-bodies present in decreased numbers during vegetative growth

References:

Genotypes:

FYPO:0000280 - sterile

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF00270DEADDEAD/DEAH_box_helicase_domPfam
PF00271Helicase_CHelicase_C-likePfam
cd17940DEADc_DDX6CDD
cd18787SF2_C_DEADCDD
PS00039DEAD_ATP_HELICASERNA-helicase_DEAD-box_CSPROSITE patterns
PS51192HELICASE_ATP_BIND_1Helicase_ATP-bdPROSITE profiles
PS51194HELICASE_CTERHelicase_C-likePROSITE profiles
PS51195Q_MOTIFRNA_helicase_DEAD_Q_motifPROSITE profiles
SM00487DEXDcHelicase_ATP-bdSMART
SM00490HELICcHelicase_C-likeSMART
G3DSA:3.40.50.300:FF:000114CATH-FunFam
G3DSA:3.40.50.300:FF:000364CATH-FunFam
G3DSA:3.40.50.300P-loop_NTPaseCATH-Gene3D
SSF52540P-loop_NTPaseSUPERFAMILY
PTHR47960PANTHER
mobidb-lite-Disorderdisorder_predictionMobiDB-Disorder

Orthologs

References / Literature

PMID:28031482 - Involvement of fission yeast Pdc2 in RNA degradation and P-body function.
Wang CY et al. RNA 2017 Apr;23(4):493-503
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:39476757 - Characterization of Ksg1 protein kinase-dependent phosphoproteome in the fission yeast S. pombe.
Cipak L et al. Biochem Biophys Res Commun 2024 Oct 25;736:150895
PMID:34496258 - Transcription and chromatin-based surveillance mechanism controls suppression of cryptic antisense transcription.
Heo DH et al. Cell Rep 2021 Sep 07;36(10):109671
PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.
Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:26537787 - Targeting of SUMO substrates to a Cdc48-Ufd1-Npl4 segregase and STUbL pathway in fission yeast.
Køhler JB et al. Nat Commun 2015 Nov 05;6:8827
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.
Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:8078473 - The ste13+ gene encoding a putative RNA helicase is essential for nitrogen starvation-induced G1 arrest and initiation of sexual development in the fission yeast Schizosaccharomyces pombe.
Maekawa H et al. Mol Gen Genet 1994 Sep 01;244(5):456-64
PMID:31822915 - Mkt1 is required for RNAi-mediated silencing and establishment of heterochromatin in fission yeast.
Taglini F et al. Nucleic Acids Res 2020 Feb 20;48(3):1239-1253
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
GO_REF:0000002 - Comments
PMID:41298081 - Gamete fusion triggers cytosolic functions and P-body recruitment of the RNA-binding protein Mei2 to drive fission yeast zygotic development.
Araoyinbo A et al. Genes Dev 2025 Nov 26;
PMID:32071154 - Fission Yeast Puf2, a Pumilio and FBF Family RNA-Binding Protein, Links Stress Granules to Processing Bodies.
Hsiao WY et al. Mol Cell Biol 2020 Apr 13;40(9)
PMID:26412298 - A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.
Beckley JR et al. Mol Cell Proteomics 2015 Dec;14(12):3132-41
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:23319050 - Pdc1 functions in the assembly of P bodies in Schizosaccharomyces pombe.
Wang CY et al. Mol Cell Biol 2013 Mar;33(6):1244-53
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:19336419 - Cotranscriptional recruitment of the nuclear poly(A)-binding protein Pab2 to nascent transcripts and association with translating mRNPs.
Lemieux C et al. Nucleic Acids Res 2009 Jun;37(10):3418-30
PMID:24713849 - Post-transcriptional regulation of meiotic genes by a nuclear RNA silencing complex.
Egan ED et al. RNA 2014 Jun;20(6):867-81
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:28218250 - Chromatin remodeller Fun30 Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.
Lee J et al. Nat Commun 2017 Feb 20;8:14527
PMID:27354705 - The S. pombe mRNA decapping complex recruits cofactors and an Edc1-like activator through a single dynamic surface.
Wurm JP et al. RNA 2016 Sep;22(9):1360-72
PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.
Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.
Halova L et al. Open Biol 2021 Apr;11(4):200405
PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.
Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514
PMID:8575018 - Two novel genes involved in the sexual development of Schizosaccharomyces pombe.
Molnar M et al. Curr Genet 1995 Oct;28(5):447-53
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:27918601 - Identifying genes required for respiratory growth of fission yeast.
Malecki M et al. Wellcome Open Res 2016;1:12