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protein coding gene - pmh1 (SPBC776.18c) - transcription factor TFIIK complex ubiquitin-protein ligase E3 subunit, Pmh1

Gene summary

Standard name
pmh1
Systematic ID
SPBC776.18c
Product
transcription factor TFIIK complex ubiquitin-protein ligase E3 subunit, Pmh1
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
mcr1
UniProt ID
O94684
ORFeome ID
50/50D12
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 3211191..3213716 reverse strand

Annotation

Comment

PBO:0000206 - deletion mutant expression profiling

References:

GO biological process

GO:0006289 - nucleotide-excision repair

References:

GO:0006357 - regulation of transcription by RNA polymerase II

References:

GO:0006367 - transcription initiation at RNA polymerase II promoter

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GO cellular component

GO:0005829 - cytosol

References:

GO:0000112 - nucleotide-excision repair factor 3 complex

References:

GO:0005634 - nucleus

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GO:0070985 - transcription factor TFIIK complex

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GO molecular function

GO:0061575 - cyclin-dependent protein serine/threonine kinase activator activity

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GO:0016251 - RNA polymerase II general transcription initiation factor activity

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GO:0061630 - ubiquitin protein ligase activity

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Modification

MOD:00046 - O-phospho-L-serine

References:

MOD:00696 - phosphorylated residue

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Multi-locus phenotype

FYPO:0002430 - inviable after spore germination, multiple cell divisions

References:

Genotypes:

FYPO:0004495 - inviable branched, swollen, elongated, multiseptate vegetative cell

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

Protein features

PBO:0111749 - ubiquitin-protein ligase E3

PBO:0111746 - zf-C3HC4 type (RING finger)

PBO:0111743 - zinc finger protein

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0000082 - decreased cell population growth at high temperature

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Genotypes:

FYPO:0004903 - decreased level of cell separation after cytokinesis gene mRNA during vegetative growth

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Genotypes:

FYPO:0005090 - decreased level of cytokinesis gene mRNA during vegetative growth

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Genotypes:

FYPO:0004068 - decreased phosphorylation of RNA polymerase II C-terminal domain serine 5 residues during vegetative growth

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Genotypes:

FYPO:0001324 - decreased protein level during vegetative growth

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Genotypes:

FYPO:0003836 - decreased RNA polymerase II carboxy-terminal domain kinase activity

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Genotypes:

FYPO:0005088 - inviable after spore germination, multiple cell divisions, binucleate septated cell

References:

Genotypes:

FYPO:0002170 - inviable after spore germination, multiple cell divisions, branched, elongated cell

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0002888 - mitotic cell cycle arrest before cell separation

References:

Genotypes:

FYPO:0001252 - multinucleate multiseptate vegetative cell

References:

Genotypes:

FYPO:0001164 - normal growth on glucose carbon source

References:

Genotypes:

FYPO:0004423 - normal protein threonine phosphorylation

References:

Genotypes:

FYPO:0001317 - normal RNA level during vegetative growth

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF06391MAT1MAT1_centrePfam
PF17121zf-C3HC4_5Znf_RINGPfam
cd16573RING-HC_TFB3-likeCDD
PS00518ZF_RING_1Znf_RING_CSPROSITE patterns
PS50089ZF_RING_2Znf_RINGPROSITE profiles
G3DSA:3.30.40.10:FF:000037CATH-FunFam
G3DSA:3.30.40.10Znf_RING/FYVE/PHDCATH-Gene3D
SSF57850SUPERFAMILY
PTHR12683PANTHER
PIRSF003338MAT1_metazoaMAT1/Tfb3PIRSF
TIGR00570cdk7MAT1/Tfb3NCBIFAM
CoilCOILS

Orthologs

References / Literature

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:39476757 - Characterization of Ksg1 protein kinase-dependent phosphoproteome in the fission yeast S. pombe.
Cipak L et al. Biochem Biophys Res Commun 2024 Oct 25;736:150895
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:15829570 - Impairment of the TFIIH-associated CDK-activating kinase selectively affects cell cycle-regulated gene expression in fission yeast.
Lee KM et al. Mol Biol Cell 2005 Jun;16(6):2734-45
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:15555586 - Mcs2 and a novel CAK subunit Pmh1 associate with Skp1 in fission yeast.
Bamps S et al. Biochem Biophys Res Commun 2004 Dec 24;325(4):1424-32
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:27298342 - Identification of S-phase DNA damage-response targets in fission yeast reveals conservation of damage-response networks.
Willis NA et al. Proc Natl Acad Sci U S A 2016 Jun 28;113(26):E3676-85
PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.
Halova L et al. Open Biol 2021 Apr;11(4):200405
PMID:14534314 - Mediator influences Schizosaccharomyces pombe RNA polymerase II-dependent transcription in vitro.
Spahr H et al. J Biol Chem 2003 Dec 19;278(51):51301-6
PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.
Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514
PMID:20118936 - Schizosaccharomyces pombe genome-wide nucleosome mapping reveals positioning mechanisms distinct from those of Saccharomyces cerevisiae.
Lantermann AB et al. Nat Struct Mol Biol 2010 Feb;17(2):251-7
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:17016471 - Repression of ergosterol level during oxidative stress by fission yeast F-box protein Pof14 independently of SCF.
Tafforeau L et al. EMBO J 2006 Oct 04;25(19):4547-56
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:39094570 - A replisome-associated histone H3-H4 chaperone required for epigenetic inheritance.
Yu J et al. Cell 2024 Sep 05;187(18):5010-5028.e24
GO_REF:0000050 - Manual transfer of GO annotation data to genes by curator judgment of sequence model