protein coding gene - clr3 (SPBC800.03) - SHREC complex histone deacetylase (class II) subunit, Clr3

Gene summary

Standard name

clr3

Systematic ID

SPBC800.03

Product

SHREC complex histone deacetylase (class II) subunit, Clr3

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

P56523

ORFeome ID

37/37C08

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome II: 254686..257138 forward strand

Annotation

Protein features

Orthologs

• HDAC6 (HGNC:14064) Homo sapiens
• HDAC10 (HGNC:18128) Homo sapiens
• clr3 (SJAG_03844) Schizosaccharomyces japonicus
• HDA1 (YNL021W) Saccharomyces cerevisiae

References / Literature

PMID:38815580 - RNA quality control factors nucleate Clr4/SUV39H and trigger constitutive heterochromatin assembly.

Khanduja JS et al. Cell 2024 May 21;

PMID:28942089 - Biochemical Basis for Distinct Roles of the Heterochromatin Proteins Swi6 and Chp2.

Isaac RS et al. J Mol Biol 2017 Nov 24;429(23):3666-3677

PMID:26205977 - Highly condensed chromatins are formed adjacent to subtelomeric and decondensed silent chromatin in fission yeast.

Matsuda A et al. Nat Commun 2015 Jul 24;6:7753

PMID:23695164 - Cross-species protein interactome mapping reveals species-specific wiring of stress response pathways.

Das J et al. Sci Signal 2013 May 21;6(276):ra38

PMID:25245948 - Tls1 regulates splicing of shelterin components to control telomeric heterochromatin assembly and telomere length.

Wang J et al. Nucleic Acids Res 2014 Oct;42(18):11419-32

PMID:19443688 - Diverse roles of HP1 proteins in heterochromatin assembly and functions in fission yeast.

Fischer T et al. Proc Natl Acad Sci U S A 2009 Jun 02;106(22):8998-9003

PMID:39096900 - Nucleosome remodeler exclusion by histone deacetylation enforces heterochromatic silencing and epigenetic inheritance.

Sahu RK et al. Mol Cell 2024 Sep 05;84(17):3175-3191.e8

PMID:23572080 - Distinct roles for Sir2 and RNAi in centromeric heterochromatin nucleation, spreading and maintenance.

Buscaino A et al. EMBO J 2013 May 02;32(9):1250-64

PMID:25831549 - Epigenetics. Epigenetic inheritance uncoupled from sequence-specific recruitment.

Ragunathan K et al. Science 2015 Apr 03;348(6230):1258699

PMID:24957674 - Yeast X-chromosome-associated protein 5 (Xap5) functions with H2A.Z to suppress aberrant transcripts.

Anver S et al. EMBO Rep 2014 Aug;15(8):894-902

PMID:21892171 - Defects in RNA quality control factors reveal RNAi-independent nucleation of heterochromatin.

Reyes-Turcu FE et al. Nat Struct Mol Biol 2011 Sep 04;18(10):1132-8

PMID:22302936 - Tel1(ATM) and Rad3(ATR) phosphorylate the telomere protein Ccq1 to recruit telomerase and elongate telomeres in fission yeast.

Yamazaki H et al. Genes Dev 2012 Feb 01;26(3):241-6

PMID:26510788 - Escape from Mitotic Arrest: An Unexpected Connection Between Microtubule Dynamics and Epigenetic Regulation of Centromeric Chromatin in Schizosaccharomyces pombe.

George AA et al. Genetics 2015 Dec;201(4):1467-78

PMID:21253571 - H3K9me-independent gene silencing in fission yeast heterochromatin by Clr5 and histone deacetylases.

Hansen KR et al. PLoS Genet 2011 Jan 06;7(1):e1001268

PMID:32435206 - Posttranslational Arginylation Enzyme Arginyltransferase1 Shows Genetic Interactions With Specific Cellular Pathways in vivo .

Wiley DJ et al. Front Physiol 2020;11:427

PMID:19164572 - Msc1 links dynamic Swi6/HP1 binding to cell fate determination.

Lawrence RJ et al. Proc Natl Acad Sci U S A 2009 Jan 27;106(4):1163-8

PMID:18354085 - Diminishing HDACs by drugs or mutations promotes normal or abnormal sister chromatid separation by affecting APC/C and adherin.

Kimata Y et al. J Cell Sci 2008 Apr 01;121(Pt 7):1107-18

PMID:34731638 - The histone chaperone FACT facilitates heterochromatin spreading by regulating histone turnover and H3K9 methylation states.

Murawska M et al. Cell Rep 2021 Nov 02;37(5):109944

PMID:16246721 - The nucleation and maintenance of heterochromatin by a histone deacetylase in fission yeast.

Yamada T et al. Mol Cell 2005 Oct 28;20(2):173-85

PMID:18684775 - A genome-wide screen of genes involved in cadmium tolerance in Schizosaccharomyces pombe.

Kennedy PJ et al. Toxicol Sci 2008 Nov;106(1):124-39

PMID:21333630 - Sde2: a novel nuclear protein essential for telomeric silencing and genomic stability in Schizosaccharomyces pombe.

Sugioka-Sugiyama R et al. Biochem Biophys Res Commun 2011 Mar 18;406(3):444-8

PMID:20194963 - Transformation/transcription domain-associated protein (TRRAP)-mediated regulation of Wee1.

Calonge TM et al. Genetics 2010 May;185(1):81-93

PMID:20299449 - A chromodomain switch mediated by histone H3 Lys 4 acetylation regulates heterochromatin assembly.

Xhemalce B et al. Genes Dev 2010 Apr 01;24(7):647-52

PMID:8937982 - Mutations in the fission yeast silencing factors clr4+ and rik1+ disrupt the localisation of the chromo domain protein Swi6p and impair centromere function.

Ekwall K et al. J Cell Sci 1996 Nov;109 ( Pt 11):2637-48

PMID:23050226 - A genetic screen to discover pathways affecting cohesin function in Schizosaccharomyces pombe identifies chromatin effectors.

Chen Z et al. G3 (Bethesda) 2012 Oct;2(10):1161-8

PMID:23851719 - Spt6 prevents transcription-coupled loss of posttranslationally modified histone H3.

Kato H et al. Sci Rep 2013;3:2186

PMID:26354422 - Ccq1-Tpz1TPP1 interaction facilitates telomerase and SHREC association with telomeres in fission yeast.

Moser BA et al. Mol Biol Cell 2015 Nov 01;26(21):3857-66

PMID:32269268 - Abo1 is required for the H3K9me2 to H3K9me3 transition in heterochromatin.

Dong W et al. Sci Rep 2020 Apr 08;10(1):6055

PMID:22144463 - RNA elimination machinery targeting meiotic mRNAs promotes facultative heterochromatin formation.

Zofall M et al. Science 2012 Jan 06;335(6064):96-100

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:30355493 - Expanded Interactome of the Intrinsically Disordered Protein Dss1.

Schenstrøm SM et al. Cell Rep 2018 Oct 23;25(4):862-870

PMID:11884604 - Functional divergence between histone deacetylases in fission yeast by distinct cellular localization and in vivo specificity.

Bjerling P et al. Mol Cell Biol 2002 Apr;22(7):2170-81

PMID:26365187 - Dissecting Fission Yeast Shelterin Interactions via MICro-MS Links Disruption of Shelterin Bridge to Tumorigenesis.

Liu J et al. Cell Rep 2015 Sep 29;12(12):2169-80

PMID:9755190 - Histone deacetylase homologs regulate epigenetic inheritance of transcriptional silencing and chromosome segregation in fission yeast.

Grewal SI et al. Genetics 1998 Oct;150(2):563-76

PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.

Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160

PMID:31206516 - Regulation of ectopic heterochromatin-mediated epigenetic diversification by the JmjC family protein Epe1.

Sorida M et al. PLoS Genet 2019 Jun;15(6):e1008129

PMID:40063661 - Fission yeast Caprin protein is required for efficient heterochromatin establishment.

Zhang H et al. PLoS Genet 2025 Mar 10;21(3):e1011620

PMID:26988418 - The proper connection between shelterin components is required for telomeric heterochromatin assembly.

Wang J et al. Genes Dev 2016 Apr 01;30(7):827-39

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704

PMID:38285941 - Specialized replication of heterochromatin domains ensures self-templated chromatin assembly and epigenetic inheritance.

Nathanailidou P et al. Proc Natl Acad Sci U S A 2024 Feb 06;121(6):e2315596121

PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.

Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963

PMID:8138176 - Mutations in rik1, clr2, clr3 and clr4 genes asymmetrically derepress the silent mating-type loci in fission yeast.

Ekwall K et al. Genetics 1994 Jan;136(1):53-64

PMID:18505873 - Schizosaccharomyces pombe histone acetyltransferase Mst1 (KAT5) is an essential protein required for damage response and chromosome segregation.

Gómez EB et al. Genetics 2008 Jun;179(2):757-71

PMID:28281664 - Genetic interactions and functional analyses of the fission yeast gsk3 and amk2 single and double mutants defective in TORC1-dependent processes.

Rallis C et al. Sci Rep 2017 Mar 10;7:44257

PMID:21211723 - Asf1/HIRA facilitate global histone deacetylation and associate with HP1 to promote nucleosome occupancy at heterochromatic loci.

Yamane K et al. Mol Cell 2011 Jan 07;41(1):56-66

PMID:24662054 - The Mi-2 homolog Mit1 actively positions nucleosomes within heterochromatin to suppress transcription.

Creamer KM et al. Mol Cell Biol 2014 Jun;34(11):2046-61

PMID:28218250 - Chromatin remodeller Fun30 Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Lee J et al. Nat Commun 2017 Feb 20;8:14527

PMID:25497836 - Heterochromatin assembly and transcriptome repression by Set1 in coordination with a class II histone deacetylase.

Lorenz DR et al. Elife 2014 Dec 15;3:e04506

PMID:17289569 - SHREC, an effector complex for heterochromatic transcriptional silencing.

Sugiyama T et al. Cell 2007 Feb 09;128(3):491-504

PMID:20421495 - RNAi and heterochromatin repress centromeric meiotic recombination.

Ellermeier C et al. Proc Natl Acad Sci U S A 2010 May 11;107(19):8701-5

PMID:15292231 - Regulation of Swi6/HP1-dependent heterochromatin assembly by cooperation of components of the mitogen-activated protein kinase pathway and a histone deacetylase Clr6.

Kim HS et al. J Biol Chem 2004 Oct 08;279(41):42850-9

PMID:19633696 - HAT-HDAC interplay modulates global histone H3K14 acetylation in gene-coding regions during stress.

Johnsson A et al. EMBO Rep 2009 Sep;10(9):1009-14

PMID:20062003 - Hairpin RNA induces secondary small interfering RNA synthesis and silencing in trans in fission yeast.

Simmer F et al. EMBO Rep 2010 Feb;11(2):112-8

PMID:33378674 - The INO80 Complex Regulates Epigenetic Inheritance of Heterochromatin.

Shan CM et al. Cell Rep 2020 Dec 29;33(13):108561

PMID:37445861 - Resistance to Chemotherapeutic 5-Fluorouracil Conferred by Modulation of Heterochromatic Integrity through Ino80 Function in Fission Yeast.

Lim KK et al. Int J Mol Sci 2023 Jun 26;24(13)

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:23874237 - Modification of tRNA(Lys) UUU by elongator is essential for efficient translation of stress mRNAs.

Fernández-Vázquez J et al. PLoS Genet 2013;9(7):e1003647

PMID:24013500 - A conserved ncRNA-binding protein recruits silencing factors to heterochromatin through an RNAi-independent mechanism.

Marina DB et al. Genes Dev 2013 Sep 01;27(17):1851-6

PMID:24013502 - Epe1 recruits BET family bromodomain protein Bdf2 to establish heterochromatin boundaries.

Wang J et al. Genes Dev 2013 Sep 01;27(17):1886-902

PMID:32415063 - Conserved protein Pir2 ARS2 mediates gene repression through cryptic introns in lncRNAs.

Thillainadesan G et al. Nat Commun 2020 May 15;11(1):2412

PMID:26173815 - Genome-wide screen of fission yeast mutants for sensitivity to 6-azauracil, an inhibitor of transcriptional elongation.

Zhou H et al. Yeast 2015 Oct;32(10):643-55

PMID:26098123 - Promoter nucleosome dynamics regulated by signalling through the CTD code.

Materne P et al. Elife 2015 Jun 22;4:e09008

PMID:27105116 - SHREC Silences Heterochromatin via Distinct Remodeling and Deacetylation Modules.

Job G et al. Mol Cell 2016 Apr 21;62(2):207-221

PMID:16762840 - Swi6/HP1 recruits a JmjC domain protein to facilitate transcription of heterochromatic repeats.

Zofall M et al. Mol Cell 2006 Jun 09;22(5):681-92

PMID:20675407 - Combinatorial, site-specific requirement for heterochromatic silencing factors in the elimination of nucleosome-free regions.

Garcia JF et al. Genes Dev 2010 Aug 15;24(16):1758-71

PMID:19723888 - Inhibition of type I histone deacetylase increases resistance of checkpoint-deficient cells to genotoxic agents through mitotic delay.

Alao JP et al. Mol Cancer Ther 2009 Sep;8(9):2606-15

PMID:21504829 - Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.

Stewart EV et al. Mol Cell 2011 Apr 22;42(2):160-71

PMID:28318821 - SNF2 Family Protein Fft3 Suppresses Nucleosome Turnover to Promote Epigenetic Inheritance and Proper Replication.

Taneja N et al. Mol Cell 2017 Apr 06;66(1):50-62.e6

PMID:26744419 - Control of heterochromatin localization and silencing by the nuclear membrane protein Lem2.

Barrales RR et al. Genes Dev 2016 Jan 15;30(2):133-48

PMID:28410370 - A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.

Dudin O et al. PLoS Genet 2017 Apr;13(4):e1006721

PMID:36200823 - The chromatin remodeler RSC prevents ectopic CENP-A propagation into pericentromeric heterochromatin at the chromatin boundary.

Tsunemine S et al. Nucleic Acids Res 2022 Oct 28;50(19):10914-10928

PMID:18493607 - A DNA polymerase alpha accessory protein, Mcl1, is required for propagation of centromere structures in fission yeast.

Natsume T et al. PLoS One 2008 May 21;3(5):e2221

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:26889830 - A Novel Epigenetic Silencing Pathway Involving the Highly Conserved 5'-3' Exoribonuclease Dhp1/Rat1/Xrn2 in Schizosaccharomyces pombe.

Tucker JF et al. PLoS Genet 2016 Feb;12(2):e1005873

PMID:12193658 - Histone H3 lysine 4 methylation is mediated by Set1 and promotes maintenance of active chromatin states in fission yeast.

Noma K et al. Proc Natl Acad Sci U S A 2002 Dec 10;99 Suppl 4(Suppl 4):16438-45

PMID:23091701 - Impaired coenzyme A synthesis in fission yeast causes defective mitosis, quiescence-exit failure, histone hypoacetylation and fragile DNA.

Nakamura T et al. Open Biol 2012 Sep;2(9):120117

PMID:26518661 - The Paf1 complex factors Leo1 and Paf1 promote local histone turnover to modulate chromatin states in fission yeast.

Sadeghi L et al. EMBO Rep 2015 Dec;16(12):1673-87

PMID:29216371 - Fission yeast Ccq1 is a modulator of telomerase activity.

Armstrong CA et al. Nucleic Acids Res 2018 Jan 25;46(2):704-716

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:12867036 - Sir2 regulates histone H3 lysine 9 methylation and heterochromatin assembly in fission yeast.

Shankaranarayana GD et al. Curr Biol 2003 Jul 15;13(14):1240-6

PMID:23163955 - Analysis of stress-induced duplex destabilization (SIDD) properties of replication origins, genes and intergenes in the fission yeast, Schizosaccharomyces pombe.

Yadav MP et al. BMC Res Notes 2012 Nov 19;5:643

PMID:41501458 - Stress controls heterochromatin inheritance via histone H3 ubiquitylation.

Bhatt B et al. Nature 2026 Jan 07;

PMID:11283354 - Role of histone H3 lysine 9 methylation in epigenetic control of heterochromatin assembly.

Nakayama J et al. Science 2001 Apr 06;292(5514):110-3

PMID:18931302 - Significant conservation of synthetic lethal genetic interaction networks between distantly related eukaryotes.

Dixon SJ et al. Proc Natl Acad Sci U S A 2008 Oct 28;105(43):16653-8

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.

Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323

PMID:28636937 - The Conserved RNA Binding Cyclophilin, Rct1, Regulates Small RNA Biogenesis and Splicing Independent of Heterochromatin Assembly.

Chang AY et al. Cell Rep 2017 Jun 20;19(12):2477-2489

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:41786738 - An H3K14ub-H3K9me3 feedback circuit governs heterochromatin spreading and inheritance in fission yeast.

Toda T et al. Nat Commun 2026 Mar 05;

PMID:22990236 - Hrp3 controls nucleosome positioning to suppress non-coding transcription in eu- and heterochromatin.

Shim YS et al. EMBO J 2012 Nov 28;31(23):4375-87

PMID:18818364 - Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast.

Roguev A et al. Science 2008 Oct 17;322(5900):405-10

PMID:29852001 - New insights into donor directionality of mating-type switching in Schizosaccharomyces pombe.

Maki T et al. PLoS Genet 2018 May;14(5):e1007424

PMID:38289024 - Heat stress-induced activation of MAPK pathway attenuates Atf1-dependent epigenetic inheritance of heterochromatin in fission yeast.

Sun L et al. Elife 2024 Jan 30;13

PMID:12773576 - A novel jmjC domain protein modulates heterochromatization in fission yeast.

Ayoub N et al. Mol Cell Biol 2003 Jun;23(12):4356-70

PMID:29618061 - Histone deacetylation promotes transcriptional silencing at facultative heterochromatin.

Watts BR et al. Nucleic Acids Res 2018 Jun 20;46(11):5426-5440

PMID:30652128 - Heterochromatin suppresses gross chromosomal rearrangements at centromeres by repressing Tfs1/TFIIS-dependent transcription.

Okita AK et al. Commun Biol 2019;2:17

PMID:8001791 - Three additional linkage groups that repress transcription and meiotic recombination in the mating-type region of Schizosaccharomyces pombe.

Thon G et al. Genetics 1994 Sep;138(1):29-38

PMID:22992726 - The SAGA histone acetyltransferase complex regulates leucine uptake through the Agp3 permease in fission yeast.

Takahashi H et al. J Biol Chem 2012 Nov 02;287(45):38158-67

PMID:19111658 - HP1 proteins form distinct complexes and mediate heterochromatic gene silencing by nonoverlapping mechanisms.

Motamedi MR et al. Mol Cell 2008 Dec 26;32(6):778-90

PMID:31262821 - Replication fork stalling elicits chromatin compaction for the stability of stalling replication forks.

Feng G et al. Proc Natl Acad Sci U S A 2019 Jul 16;116(29):14563-14572

PMID:16079916 - Genomewide analysis of nucleosome density histone acetylation and HDAC function in fission yeast.

Wirén M et al. EMBO J 2005 Aug 17;24(16):2906-18

PMID:19136623 - Phosphorylation of Swi6/HP1 regulates transcriptional gene silencing at heterochromatin.

Shimada A et al. Genes Dev 2009 Jan 01;23(1):18-23

PMID:20211136 - Stc1: a critical link between RNAi and chromatin modification required for heterochromatin integrity.

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PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:31278118 - Cohesin Impedes Heterochromatin Assembly in Fission Yeast Cells Lacking Pds5.

Folco HD et al. Genetics 2019 Sep;213(1):127-141

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

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PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:15632061 - Global effects on gene expression in fission yeast by silencing and RNA interference machineries.

Hansen KR et al. Mol Cell Biol 2005 Jan;25(2):590-601

PMID:18094683 - Host genome surveillance for retrotransposons by transposon-derived proteins.

Cam HP et al. Nature 2008 Jan 24;451(7177):431-6

PMID:18615848 - Role of heterochromatin in suppressing subtelomeric recombination in fission yeast.

Bisht KK et al. Yeast 2008 Aug;25(8):537-48

PMID:30110338 - The binding of Chp2's chromodomain to methylated H3K9 is essential for Chp2's role in heterochromatin assembly in fission yeast.

Maksimov V et al. PLoS One 2018;13(8):e0201101

PMID:30573453 - Anti-silencing factor Epe1 associates with SAGA to regulate transcription within heterochromatin.

Bao K et al. Genes Dev 2019 Jan 01;33(1-2):116-126

PMID:23771057 - Sir2 is required for Clr4 to initiate centromeric heterochromatin assembly in fission yeast.

Alper BJ et al. EMBO J 2013 Aug 28;32(17):2321-35

PMID:24240238 - Elimination of shelterin components bypasses RNAi for pericentric heterochromatin assembly.

Tadeo X et al. Genes Dev 2013 Nov 15;27(22):2489-99

PMID:28682306 - Unique roles for histone H3K9me states in RNAi and heritable silencing of transcription.

Jih G et al. Nature 2017 Jul 27;547(7664):463-467

PMID:21850271 - Genome-wide screening for genes associated with FK506 sensitivity in fission yeast.

Ma Y et al. PLoS One 2011;6(8):e23422

PMID:29259000 - Genes Important for Schizosaccharomyces pombe Meiosis Identified Through a Functional Genomics Screen.

Blyth J et al. Genetics 2018 Feb;208(2):589-603

PMID:32295063 - The Catalytic-Dependent and -Independent Roles of Lsd1 and Lsd2 Lysine Demethylases in Heterochromatin Formation in Schizosaccharomyces pombe .

Marayati BF et al. Cells 2020 Apr 13;9(4)

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:18030666 - Mutations in deoxyribonucleotide biosynthesis pathway cause spreading of silencing across heterochromatic barriers at the mating-type region of the fission yeast.

Singh G et al. Yeast 2008 Feb;25(2):117-28

PMID:19547744 - Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Beltrao P et al. PLoS Biol 2009 Jun 16;7(6):e1000134

PMID:25373780 - A genomic Multiprocess survey of machineries that control and link cell shape, microtubule organization, and cell-cycle progression.

Graml V et al. Dev Cell 2014 Oct 27;31(2):227-239

PMID:18809570 - Balance between distinct HP1 family proteins controls heterochromatin assembly in fission yeast.

Sadaie M et al. Mol Cell Biol 2008 Dec;28(23):6973-88

PMID:18345014 - Roles of the Clr4 methyltransferase complex in nucleation, spreading and maintenance of heterochromatin.

Zhang K et al. Nat Struct Mol Biol 2008 Apr;15(4):381-8