protein coding gene - atb2 (SPBC800.05c) - tubulin alpha 2

Gene summary

Standard name

atb2

Systematic ID

SPBC800.05c

Product

tubulin alpha 2

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

tub1, alp2, ban5

UniProt ID

P04689

ORFeome ID

32/32H06

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome II: 260309..262116 reverse strand

Annotation

Protein features

Orthologs

• TUBA4A (HGNC:12407) Homo sapiens
• TUBA3C (HGNC:12408) Homo sapiens
• TUBA8 (HGNC:12410) Homo sapiens
• TUBA4B (HGNC:18637) Homo sapiens
• TUBA1B (HGNC:18809) Homo sapiens
• TUBA3E (HGNC:20765) Homo sapiens
• TUBA1A (HGNC:20766) Homo sapiens
• TUBA1C (HGNC:20768) Homo sapiens
• TUBA3D (HGNC:24071) Homo sapiens
• atb2 (SJAG_02509) Schizosaccharomyces japonicus
• TUB1 (YML085C) Saccharomyces cerevisiae
• TUB3 (YML124C) Saccharomyces cerevisiae

References / Literature

PMID:9658169 - Identification of novel temperature-sensitive lethal alleles in essential beta-tubulin and nonessential alpha 2-tubulin genes as fission yeast polarity mutants.

Radcliffe P et al. Mol Biol Cell 1998 Jul;9(7):1757-71

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:14767070 - Mmd1p, a novel, conserved protein essential for normal mitochondrial morphology and distribution in the fission yeast Schizosaccharomyces pombe.

Weir BA et al. Mol Biol Cell 2004 Apr;15(4):1656-65

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs

PMID:18684775 - A genome-wide screen of genes involved in cadmium tolerance in Schizosaccharomyces pombe.

Kennedy PJ et al. Toxicol Sci 2008 Nov;106(1):124-39

PMID:32848252 - Closed mitosis requires local disassembly of the nuclear envelope.

Dey G et al. Nature 2020 Sep;585(7823):119-123

PMID:23885124 - Fission yeast MOZART1/Mzt1 is an essential γ-tubulin complex component required for complex recruitment to the microtubule organizing center, but not its assembly.

Masuda H et al. Mol Biol Cell 2013 Sep;24(18):2894-906

PMID:33137104 - The prefoldin complex stabilizes the von Hippel-Lindau protein against aggregation and degradation.

Chesnel F et al. PLoS Genet 2020 Nov;16(11):e1009183

PMID:3785193 - Differential expressions of essential and nonessential alpha-tubulin genes in Schizosaccharomyces pombe.

Adachi Y et al. Mol Cell Biol 1986 Jun;6(6):2168-78

PMID:9573052 - Pom1p, a fission yeast protein kinase that provides positional information for both polarized growth and cytokinesis.

Bähler J et al. Genes Dev 1998 May 01;12(9):1356-70

PMID:20967237 - Fission yeast cells undergo nuclear division in the absence of spindle microtubules.

Castagnetti S et al. PLoS Biol 2010 Oct 12;8(10):e1000512

PMID:17442892 - The conserved Spc7 protein is required for spindle integrity and links kinetochore complexes in fission yeast.

Kerres A et al. Mol Biol Cell 2007 Jul;18(7):2441-54

PMID:18495844 - Interphase microtubule bundles use global cell shape to guide spindle alignment in fission yeast.

Daga RR et al. J Cell Sci 2008 Jun 15;121(Pt 12):1973-80

PMID:22264709 - TUBA1A mutation-associated lissencephaly: case report and review of the literature.

Sohal AP et al. Pediatr Neurol 2012 Feb;46(2):127-31

PMID:22119525 - SIN-inhibitory phosphatase complex promotes Cdc11p dephosphorylation and propagates SIN asymmetry in fission yeast.

Singh NS et al. Curr Biol 2011 Dec 06;21(23):1968-78

PMID:22500803 - EBs recognize a nucleotide-dependent structural cap at growing microtubule ends.

Maurer SP et al. Cell 2012 Apr 13;149(2):371-82

PMID:10473641 - Functional dissection and hierarchy of tubulin-folding cofactor homologues in fission yeast.

Radcliffe PA et al. Mol Biol Cell 1999 Sep;10(9):2987-3001

PMID:19330768 - Tubulin heterodimers remain functional for one cell cycle after the inactivation of tubulin-folding cofactor D in fission yeast cells.

Fedyanina OS et al. Yeast 2009 Apr;26(4):235-47

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:6327053 - Identification of the pleiotropic cell division cycle gene NDA2 as one of two different alpha-tubulin genes in Schizosaccharomyces pombe.

Toda T et al. Cell 1984 May;37(1):233-42

PMID:30463883 - Suppressor Analysis Uncovers That MAPs and Microtubule Dynamics Balance with the Cut7/Kinesin-5 Motor for Mitotic Spindle Assembly in Schizosaccharomyces pombe .

Yukawa M et al. G3 (Bethesda) 2019 Jan 09;9(1):269-280

PMID:21504829 - Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.

Stewart EV et al. Mol Cell 2011 Apr 22;42(2):160-71

PMID:29084823 - Phosphorylation of the RNA-binding protein Zfs1 modulates sexual differentiation in fission yeast.

Navarro FJ et al. J Cell Sci 2017 Dec 15;130(24):4144-4154

PMID:37288768 - Altered cohesin dynamics and H3K9 modifications contribute to mitotic defects in the cbf11Δ lipid metabolism mutant.

Vishwanatha A et al. J Cell Sci 2023 Jun 01;136(11)

PMID:20537132 - Global fitness profiling of fission yeast deletion strains by barcode sequencing.

Han TX et al. Genome Biol 2010;11(6):R60

PMID:8876193 - Microtubules mediate mitochondrial distribution in fission yeast.

Yaffe MP et al. Proc Natl Acad Sci U S A 1996 Oct 15;93(21):11664-8

PMID:27887640 - Functional and regulatory profiling of energy metabolism in fission yeast.

Malecki M et al. Genome Biol 2016 Nov 25;17(1):240

PMID:22540037 - Predicting the fission yeast protein interaction network.

Pancaldi V et al. G3 (Bethesda) 2012 Apr;2(4):453-67

PMID:26124291 - A stable microtubule array drives fission yeast polarity reestablishment upon quiescence exit.

Laporte D et al. J Cell Biol 2015 Jul 06;210(1):99-113

GO_REF:0000002 - Comments

PMID:18550796 - Live observation of forespore membrane formation in fission yeast.

Nakamura T et al. Mol Biol Cell 2008 Aug;19(8):3544-53

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:20118936 - Schizosaccharomyces pombe genome-wide nucleosome mapping reveals positioning mechanisms distinct from those of Saccharomyces cerevisiae.

Lantermann AB et al. Nat Struct Mol Biol 2010 Feb;17(2):251-7

PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.

Strachan J et al. J Cell Sci 2023 Dec 01;136(23)

PMID:15280226 - Functional dissection of the gamma-tubulin complex by suppressor analysis of gtb1 and alp4 mutations in Schizosaccharomyces pombe.

Tange Y et al. Genetics 2004 Jul;167(3):1095-107

PMID:6094012 - The NDA3 gene of fission yeast encodes beta-tubulin: a cold-sensitive nda3 mutation reversibly blocks spindle formation and chromosome movement in mitosis.

Hiraoka Y et al. Cell 1984 Dec;39(2 Pt 1):349-58

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:21444751 - Microtubule stabilization in vivo by nucleation-incompetent γ-tubulin complex.

Anders A et al. J Cell Sci 2011 Apr 15;124(Pt 8):1207-13

PMID:26864000 - Alp7/TACC-Alp14/TOG generates long-lived, fast-growing MTs by an unconventional mechanism.

Hussmann F et al. Sci Rep 2016 Feb 11;6:20653

PMID:29235477 - Nucleotide- and Mal3-dependent changes in fission yeast microtubules suggest a structural plasticity view of dynamics.

von Loeffelholz O et al. Nat Commun 2017 Dec 13;8(1):2110

PMID:23576550 - The dual role of fission yeast Tbc1/cofactor C orchestrates microtubule homeostasis in tubulin folding and acts as a GAP for GTPase Alp41/Arl2.

Mori R et al. Mol Biol Cell 2013 Jun;24(11):1713-24, S1-8

PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.

Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963

PMID:29930085 - Local and global Cdc42 guanine nucleotide exchange factors for fission yeast cell polarity are coordinated by microtubules and the Tea1-Tea4-Pom1 axis.

Tay YD et al. J Cell Sci 2018 Jul 19;131(14)

PMID:25002536 - A novel histone deacetylase complex in the control of transcription and genome stability.

Zilio N et al. Mol Cell Biol 2014 Sep 15;34(18):3500-14

PMID:34496258 - Transcription and chromatin-based surveillance mechanism controls suppression of cryptic antisense transcription.

Heo DH et al. Cell Rep 2021 Sep 07;36(10):109671

PMID:8522609 - Fission yeast cell morphogenesis: identification of new genes and analysis of their role during the cell cycle.

Verde F et al. J Cell Biol 1995 Dec;131(6 Pt 1):1529-38

PMID:17190604 - The Schizosaccharomyces pombe EB1 homolog Mal3p binds and stabilizes the microtubule lattice seam.

Sandblad L et al. Cell 2006 Dec 29;127(7):1415-24

PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.

Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101

PMID:30427751 - The J-domain cochaperone Rsp1 interacts with Mto1 to organize noncentrosomal microtubule assembly.

Shen J et al. Mol Biol Cell 2019 Jan 15;30(2):256-267

PMID:15837798 - Efficient formation of bipolar microtubule bundles requires microtubule-bound gamma-tubulin complexes.

Janson ME et al. J Cell Biol 2005 Apr 25;169(2):297-308

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:19571115 - Nuclear shape, growth and integrity in the closed mitosis of fission yeast depend on the Ran-GTPase system, the spindle pole body and the endoplasmic reticulum.

Gonzalez Y et al. J Cell Sci 2009 Jul 15;122(Pt 14):2464-72

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:22174761 - Roles of the DYRK kinase Pom2 in cytokinesis, mitochondrial morphology, and sporulation in fission yeast.

Wu P et al. PLoS One 2011;6(12):e28000

PMID:34951983 - Force by minus-end motors Dhc1 and Klp2 collapses the S. pombe spindle after laser ablation.

Zareiesfandabadi P et al. Biophys J 2022 Jan 18;121(2):263-276

PMID:16394105 - The V260I mutation in fission yeast alpha-tubulin Atb2 affects microtubule dynamics and EB1-Mal3 localization and activates the Bub1 branch of the spindle checkpoint.

Asakawa K et al. Mol Biol Cell 2006 Mar;17(3):1421-35

PMID:11432827 - Fission yeast ch-TOG/XMAP215 homologue Alp14 connects mitotic spindles with the kinetochore and is a component of the Mad2-dependent spindle checkpoint.

Garcia MA et al. EMBO J 2001 Jul 02;20(13):3389-401

PMID:23173672 - Identification of novel genes involved in DNA damage response by screening a genome-wide Schizosaccharomyces pombe deletion library.

Pan X et al. BMC Genomics 2012 Nov 23;13:662

PMID:11309419 - A mechanism for nuclear positioning in fission yeast based on microtubule pushing.

Tran PT et al. J Cell Biol 2001 Apr 16;153(2):397-411

PMID:15546162 - pDUAL, a multipurpose, multicopy vector capable of chromosomal integration in fission yeast.

Matsuyama A et al. Yeast 2004 Nov;21(15):1289-305

GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.

PMID:18818364 - Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast.

Roguev A et al. Science 2008 Oct 17;322(5900):405-10

PMID:24952478 - Recent advances in the genetics of dystonia.

Xiao J et al. Curr Neurol Neurosci Rep 2014 Aug;14(8):462

PMID:10978278 - The cofactor-dependent pathways for alpha- and beta-tubulins in microtubule biogenesis are functionally different in fission yeast.

Radcliffe PA et al. Genetics 2000 Sep;156(1):93-103

PMID:23427262 - The internal loop of fission yeast Ndc80 binds Alp7/TACC-Alp14/TOG and ensures proper chromosome attachment.

Tang NH et al. Mol Biol Cell 2013 Apr;24(8):1122-33

PMID:27053664 - Synergistic role of fission yeast Alp16GCP6 and Mzt1MOZART1 in γ-tubulin complex recruitment to mitotic spindle pole bodies and spindle assembly.

Masuda H et al. Mol Biol Cell 2016 Jun 01;27(11):1753-63

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704

GO_REF:0000051 - S. pombe keyword mapping

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:28218250 - Chromatin remodeller Fun30 Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Lee J et al. Nat Commun 2017 Feb 20;8:14527

PMID:9725898 - An alpha-tubulin mutant destabilizes the heterodimer: phenotypic consequences and interactions with tubulin-binding proteins.

Vega LR et al. Mol Biol Cell 1998 Sep;9(9):2349-60

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:20976105 - Silencing mediated by the Schizosaccharomyces pombe HIRA complex is dependent upon the Hpc2-like protein, Hip4.

Anderson HE et al. PLoS One 2010 Oct 18;5(10):e13488

PMID:11082048 - Identification of an alpha-tubulin mutant of fission yeast from gamma-tubulin-interacting protein screening: genetic evidence for alpha-/gamma-tubulin interaction.

Takeoka A et al. J Cell Sci 2000 Dec;113 Pt 24:4557-62

PMID:30659798 - Cryo-EM Structure (4.5-Å) of Yeast Kinesin-5-Microtubule Complex Reveals a Distinct Binding Footprint and Mechanism of Drug Resistance.

von Loeffelholz O et al. J Mol Biol 2019 Feb 15;431(4):864-872

PMID:32502403 - Selective Nuclear Pore Complex Removal Drives Nuclear Envelope Division in Fission Yeast.

Expósito-Serrano M et al. Curr Biol 2020 Aug 17;30(16):3212-3222.e2

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7