protein coding gene - rtc6 (SPBC83.06c) - mitochondrial ribosomal protein subunit L36

Gene summary

Standard name: rtc6
Systematic ID: SPBC83.06c
Product: mitochondrial ribosomal protein subunit L36
Organism: Schizosaccharomyces pombe (fission yeast)
UniProt ID: O94690
ORFeome ID: 01/01A08
Characterisation status: biological role inferred
Feature type: mRNA gene
Genomic location: chromosome II: 1520030..1520490 reverse strand

Annotation

GO biological process

GO:0032543 - mitochondrial translation

References:

GO_REF:0000111

GO cellular component

GO:0005762 - mitochondrial large ribosomal subunit

References:

GO_REF:0000033

GO:0005739 - mitochondrion

References:

PMID:16823372

GO molecular function

GO:0003735 - structural constituent of ribosome

References:

GO_REF:0000002

Protein sequence feature

SO:0001808 - mitochondrial_targeting_signal

References:

PMID:36408920

Quantitative gene expression

PBO:0011963 - RNA level

References:

PMID:23101633

Single locus phenotype

FYPO:0002111 - inviable tapered vegetative cell

References:

PMID:23697806

Genotypes:

rtc6delta

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

rtc6delta

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Warnings

PBO:0000070 - gene structure updated

References:

PMID:21511999

Protein features

ID	Name	InterPro name	DB name
PF00444	Ribosomal_L36	Ribosomal_bL36	PFAM
SSF57840	Ribosomal protein L36	Ribosomal_bL36_sp	SUPERFAMILY
PTHR46909	39S RIBOSOMAL PROTEIN L36, MITOCHONDRIAL	Mitoribosomal_bL36m	PANTHER
MF_00251	Ribosomal_bL36	Ribosomal_bL36	HAMAP
TIGR01022	rpmJ_bact	Ribosomal_bL36	NCBIFAM

Orthologs

MRPL36 (HGNC:14490) Homo sapiens
rtc6 (SJAG_03040) Schizosaccharomyces japonicus
RTC6 (YPL183W-A) Saccharomyces cerevisiae

References / Literature

PMID:21511999 - Comparative functional genomics of the fission yeasts.: Rhind N et al. Science 2011 May 20;332(6032):930-6
GO_REF:0000033 - Annotation inferences using phylogenetic trees
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:20118936 - Schizosaccharomyces pombe genome-wide nucleosome mapping reveals positioning mechanisms distinct from those of Saccharomyces cerevisiae.: Lantermann AB et al. Nat Struct Mol Biol 2010 Feb;17(2):251-7
GO_REF:0000002 - Comments
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.: Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.: Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.: Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PMID:30824696 - Systematic analysis reveals the prevalence and principles of bypassable gene essentiality.: Li J et al. Nat Commun 2019 Mar 01;10(1):1002
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.: Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.: UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.: Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623