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protein coding gene - rfc5 (SPBC83.14c) - DNA replication factor C complex subunit Rfc5

Gene summary

Standard name
rfc5
Systematic ID
SPBC83.14c
Product
DNA replication factor C complex subunit Rfc5
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O94697
ORFeome ID
20/20E03
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 1534421..1536111 reverse strand

Annotation

GO biological process

GO:1902983 - DNA strand elongation involved in mitotic DNA replication

References:

GO:0070914 - UV-damage excision repair

References:

GO cellular component

GO:0000785 - chromatin

References:

GO:0031390 - Ctf18 RFC-like complex

References:

GO:0005829 - cytosol

References:

GO:0031391 - Elg1 RFC-like complex

References:

GO:0043599 - nuclear DNA replication factor C complex

References:

GO:0005634 - nucleus

References:

GO:0031389 - Rad17 RFC-like complex

References:

GO molecular function

GO:0016887 - ATP hydrolysis activity

References:

GO:0003677 - DNA binding

References:

GO:0003689 - DNA clamp loader activity

References:

GO:0061860 - DNA clamp unloader activity

References:

Multi-locus phenotype

FYPO:0000674 - normal cell population growth at high temperature

References:

Genotypes:

FYPO:0000088 - sensitive to hydroxyurea

References:

Genotypes:

FYPO:0000089 - sensitive to methyl methanesulfonate

References:

Genotypes:

Protein features

PBO:0111792 - AAA family ATPase

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0001511 - inviable vegetative cell, abnormal cell shape, normal cell size

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF13177DNA_pol3_delta2PFAM
PF22534RFC_CPFAM
PF21960RCF1-5-like_lidPFAM
cd00009AAACDD
G3DSA:3.40.50.300:FF:000136FUNFAM
G3DSA:1.10.8.60:FF:000030FUNFAM
G3DSA:1.20.272.10:FF:000002FUNFAM
SSF52540P-loop containing nucleoside triphosphate hydrolasesP-loop_NTPaseSUPERFAMILY
SSF48019post-AAA+ oligomerization domain-likeDNA_pol3_clamp-load_cplx_CSUPERFAMILY
G3DSA:1.20.272.10GENE3D
G3DSA:1.10.8.60GENE3D
G3DSA:3.40.50.300P-loop_NTPaseGENE3D
PTHR11669REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNITDNA_Rep/Repair_Clamp_LoaderPANTHER

Orthologs

References / Literature

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:10748208 - Fidelity of eucaryotic DNA polymerase delta holoenzyme from Schizosaccharomyces pombe.
Chen X et al. J Biol Chem 2000 Jun 09;275(23):17677-82
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:16040599 - Contrasting effects of Elg1-RFC and Ctf18-RFC inactivation in the absence of fully functional RFC in fission yeast.
Kim J et al. Nucleic Acids Res 2005;33(13):4078-89
PMID:30321377 - Proteomic profiling and functional characterization of post-translational modifications of the fission yeast RNA exosome.
Telekawa C et al. Nucleic Acids Res 2018 Nov 30;46(21):11169-11183
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:24634168 - Proteome-wide search for PP2A substrates in fission yeast.
Bernal M et al. Proteomics 2014 Jun;14(11):1367-80
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:10704216 - In vitro reconstitution of the Schizosaccharomyces pombe alternative excision repair pathway.
Alleva JL et al. Biochemistry 2000 Mar 14;39(10):2659-66
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:18045993 - RFCCtf18 and the Swi1-Swi3 complex function in separate and redundant pathways required for the stabilization of replication forks to facilitate sister chromatid cohesion in Schizosaccharomyces pombe.
Ansbach AB et al. Mol Biol Cell 2008 Feb;19(2):595-607
PMID:20118936 - Schizosaccharomyces pombe genome-wide nucleosome mapping reveals positioning mechanisms distinct from those of Saccharomyces cerevisiae.
Lantermann AB et al. Nat Struct Mol Biol 2010 Feb;17(2):251-7
PMID:24713849 - Post-transcriptional regulation of meiotic genes by a nuclear RNA silencing complex.
Egan ED et al. RNA 2014 Jun;20(6):867-81
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.
Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
GO_REF:0000051 - S. pombe keyword mapping
GO_REF:0000002 - Comments
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:28218250 - Chromatin remodeller Fun30 Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.
Lee J et al. Nat Commun 2017 Feb 20;8:14527
PMID:24818994 - The S. pombe translation initiation factor eIF4G is Sumoylated and associates with the SUMO protease Ulp2.
Jongjitwimol J et al. PLoS One 2014;9(5):e94182
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7