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protein coding gene - fic1 (SPBC83.18c) - contractile ring-membrane anchor Fic1

Gene summary

Standard name
fic1
Systematic ID
SPBC83.18c
Product
contractile ring-membrane anchor Fic1
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O94701
ORFeome ID
11/11G07
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 1543492..1544775 reverse strand

Annotation

GO biological process

GO:0061245 - establishment or maintenance of bipolar cell polarity

References:

GO:1903475 - mitotic actomyosin contractile ring assembly

References:

GO:1902404 - mitotic actomyosin contractile ring contraction

References:

GO:0140278 - mitotic division septum assembly

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GO cellular component

GO:0051285 - cell cortex of cell tip

References:

GO:0032153 - cell division site

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GO:0051286 - cell tip

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GO:0005737 - cytoplasm

References:

GO:0110085 - mitotic actomyosin contractile ring

References:

GO:0120105 - mitotic actomyosin contractile ring, intermediate layer

References:

GO:0005634 - nucleus

References:

GO molecular function

GO:0106006 - cytoskeletal protein-membrane anchor activity

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GO:0005543 - phospholipid binding

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Modification

MOD:00046 - O-phospho-L-serine

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MOD:00047 - O-phospho-L-threonine

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MOD:00696 - phosphorylated residue

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MOD:01148 - ubiquitinylated lysine

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Multi-locus phenotype

FYPO:0004481 - abolished cell population growth at high temperature

References:

Genotypes:

FYPO:0000082 - decreased cell population growth at high temperature

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Genotypes:

FYPO:0000080 - decreased cell population growth at low temperature

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Genotypes:

FYPO:0001407 - decreased cell population growth on glucose carbon source

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Genotypes:

FYPO:0001355 - decreased vegetative cell population growth

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Genotypes:

FYPO:0000639 - delayed onset of septum assembly

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Genotypes:

FYPO:0007774 - increased invasive hyphal growth

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Genotypes:

FYPO:0003532 - increased monopolar index

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Genotypes:

FYPO:0004557 - increased vegetative cell population growth

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Genotypes:

FYPO:0002061 - inviable vegetative cell population

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Genotypes:

FYPO:0000674 - normal cell population growth at high temperature

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Genotypes:

FYPO:0007393 - septum mislocalized to cell tip

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Genotypes:

FYPO:0000013 - T-shaped vegetative cell with normal cell length

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Genotypes:

Protein features

PBO:0111864 - C2 domain

Qualitative gene expression

PomGeneEx:0000012 - RNA level decreased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0003013 - abnormal actomyosin contractile ring disassembly

References:

Genotypes:

FYPO:0000202 - abnormal regulation of cytokinetic cell separation

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Genotypes:

FYPO:0000026 - abnormal vegetative cell polarity

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Genotypes:

FYPO:0001018 - abolished NETO

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Genotypes:

FYPO:0002561 - abolished protein localization to actomyosin contractile ring

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Genotypes:

FYPO:0007031 - abolished protein localization to cell cortex of cell tip during mitotic interphase

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Genotypes:

FYPO:0000705 - abolished protein-protein interaction

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Genotypes:

FYPO:0003535 - decreased bipolar index

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Genotypes:

FYPO:0000251 - decreased cell population growth on galactose carbon source

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Genotypes:

FYPO:0000684 - decreased cell population growth on glycerol carbon source

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Genotypes:

FYPO:0007709 - decreased protein localization to cell cortex of non-growing cell tip

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Genotypes:

FYPO:0002871 - decreased protein localization to growing cell tip

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Genotypes:

FYPO:0004167 - increased cell population growth on glycerol carbon source

References:

Genotypes:

FYPO:0007774 - increased invasive hyphal growth

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Genotypes:

FYPO:0003532 - increased monopolar index

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Genotypes:

FYPO:0003776 - increased pseudohyphal growth

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Genotypes:

FYPO:0001309 - increased viability in stationary phase

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Genotypes:

FYPO:0005465 - normal cell polarity

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Genotypes:

FYPO:0000674 - normal cell population growth at high temperature

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Genotypes:

FYPO:0002141 - normal cell population growth at low temperature

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Genotypes:

FYPO:0001760 - normal cell separation after cytokinesis

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Genotypes:

FYPO:0006879 - normal cleavage furrow ingression

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Genotypes:

FYPO:0001396 - normal NETO

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Genotypes:

FYPO:0005905 - normal onset of actomyosin contractile ring assembly

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Genotypes:

FYPO:0008090 - normal onset of mitotic anaphase B

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Genotypes:

FYPO:0002559 - normal protein localization to actomyosin contractile ring

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Genotypes:

FYPO:0007451 - normal protein localization to cell cortex of cell tip during vegetative growth

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Genotypes:

FYPO:0001587 - normal protein localization to cell tip during vegetative growth

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Genotypes:

FYPO:0000703 - normal protein-protein interaction

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Genotypes:

FYPO:0001357 - normal vegetative cell population growth

References:

Genotypes:

FYPO:0009066 - resistance to amorolfine

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Genotypes:

FYPO:0002693 - resistance to diamide

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Genotypes:

FYPO:0009085 - resistance to lithium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0000725 - resistance to methyl methanesulfonate

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Genotypes:

FYPO:0000096 - sensitive to cadmium

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Genotypes:

FYPO:0000097 - sensitive to caffeine during vegetative growth

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Genotypes:

FYPO:0000104 - sensitive to cycloheximide

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Genotypes:

FYPO:0000799 - sensitive to diamide

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Genotypes:

FYPO:0007931 - sensitive to egtazic acid

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Genotypes:

FYPO:0000842 - sensitive to ethanol during vegetative growth

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Genotypes:

FYPO:0001719 - sensitive to lithium

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Genotypes:

FYPO:0009086 - sensitive to lithium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0006836 - sensitive to magnesium chloride

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Genotypes:

FYPO:0009088 - sensitive to magnesium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0001214 - sensitive to potassium chloride

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Genotypes:

FYPO:0009082 - sensitive to potassium chloride and methyl methanesulfonate

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Genotypes:

FYPO:0007924 - sensitive to potassium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0000271 - sensitive to salt stress

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Genotypes:

FYPO:0005889 - sensitive to sodium chloride

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Genotypes:

FYPO:0009090 - sensitive to sodium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0000086 - sensitive to tacrolimus

References:

Genotypes:

FYPO:0000797 - sensitive to tert-butyl hydroperoxide

References:

Genotypes:

FYPO:0000115 - sensitive to valproic acid

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Genotypes:

FYPO:0003656 - sensitive to vanadate

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Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0001510 - viable vegetative cell, abnormal cell shape, normal cell size

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011063 - conserved in fungi only

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF00168C2C2_domPfam
cd08681C2_fungal_Inn1p-likeC2_fungal_Inn1CDD
PS50004C2C2_domPROSITE profiles
SM00239C2C2_domSMART
G3DSA:2.60.40.150C2_domain_sfCATH-Gene3D
SSF49562C2_domain_sfSUPERFAMILY
PTHR47052Ingression_C2_domainPANTHER
mobidb-lite-Disorderdisorder_predictionMobiDB-Disorder
mobidb-lite-Positive-Polyelectrolytedisorder_predictionMobiDB-Positive-Polyelectrolyte

Orthologs

References / Literature

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.
Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PMID:26702831 - Oligomerization but Not Membrane Bending Underlies the Function of Certain F-BAR Proteins in Cell Motility and Cytokinesis.
McDonald NA et al. Dev Cell 2015 Dec 21;35(6):725-36
PMID:27887640 - Functional and regulatory profiling of energy metabolism in fission yeast.
Malecki M et al. Genome Biol 2016 Nov 25;17(1):240
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:28914606 - Nanoscale architecture of the Schizosaccharomyces pombe contractile ring.
McDonald NA et al. Elife 2017 Sep 15;6
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:20118936 - Schizosaccharomyces pombe genome-wide nucleosome mapping reveals positioning mechanisms distinct from those of Saccharomyces cerevisiae.
Lantermann AB et al. Nat Struct Mol Biol 2010 Feb;17(2):251-7
PMID:36749320 - Multiple polarity kinases inhibit phase separation of F-BAR protein Cdc15 and antagonize cytokinetic ring assembly in fission yeast.
Bhattacharjee R et al. Elife 2023 Feb 07;12
PMID:25052092 - F-BAR domain protein Rga7 collaborates with Cdc15 and Imp2 to ensure proper cytokinesis in fission yeast.
Martín-García R et al. J Cell Sci 2014 Oct 01;127(Pt 19):4146-58
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:19139265 - The SH3 domains of two PCH family members cooperate in assembly of the Schizosaccharomyces pombe contractile ring.
Roberts-Galbraith RH et al. J Cell Biol 2009 Jan 12;184(1):113-27
PMID:23093943 - Cytokinesis-based constraints on polarized cell growth in fission yeast.
Bohnert KA et al. PLoS Genet 2012;8(10):e1003004
PMID:30332655 - Paxillin-Mediated Recruitment of Calcineurin to the Contractile Ring Is Required for the Correct Progression of Cytokinesis in Fission Yeast.
Martín-García R et al. Cell Rep 2018 Oct 16;25(3):772-783.e4
PMID:32878942 - Phosphoregulation of the cytokinetic protein Fic1 contributes to fission yeast growth polarity establishment.
Bohnert KA et al. J Cell Sci 2020 Sep 17;133(18)
PMID:37158439 - The fission yeast cytokinetic ring component Fic1 promotes septum formation.
Rossi AM et al. Biol Open 2023 May 15;12(5)
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:32101481 - DYRK kinase Pom1 drives F-BAR protein Cdc15 from the membrane to promote medial division.
Bhattacharjee R et al. Mol Biol Cell 2020 Apr 15;31(9):917-929
PMID:21850271 - Genome-wide screening for genes associated with FK506 sensitivity in fission yeast.
Ma Y et al. PLoS One 2011;6(8):e23422
PMID:18684775 - A genome-wide screen of genes involved in cadmium tolerance in Schizosaccharomyces pombe.
Kennedy PJ et al. Toxicol Sci 2008 Nov;106(1):124-39
PMID:26776521 - The Tubulation Activity of a Fission Yeast F-BAR Protein Is Dispensable for Its Function in Cytokinesis.
McDonald NA et al. Cell Rep 2016 Jan 26;14(3):534-546
PMID:33357436 - Opposite Surfaces of the Cdc15 F-BAR Domain Create a Membrane Platform That Coordinates Cytoskeletal and Signaling Components for Cytokinesis.
Snider CE et al. Cell Rep 2020 Dec 22;33(12):108526
PMID:25428987 - The Cdc15 and Imp2 SH3 domains cooperatively scaffold a network of proteins that redundantly ensure efficient cell division in fission yeast.
Ren L et al. Mol Biol Cell 2015 Jan 15;26(2):256-69
PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.
Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399