protein coding gene - mcs4 (SPBC887.10) - response regulator Mcs4

Gene summary

Standard name

mcs4

Systematic ID

SPBC887.10

Product

response regulator Mcs4

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

P87323

ORFeome ID

33/33B11

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome II: 3557088..3559137 forward strand

Annotation

Protein features

Orthologs

• mcs4 (SJAG_00318) Schizosaccharomyces japonicus
• SSK1 (YLR006C) Saccharomyces cerevisiae

References / Literature

PMID:11758939 - Genetic analysis of the His-to-Asp phosphorelay implicated in mitotic cell cycle control: involvement of histidine-kinase genes of Schizosaccharomyces pombe.

Aoyama K et al. Biosci Biotechnol Biochem 2001 Oct;65(10):2347-52

PMID:9136929 - The Mcs4 response regulator coordinately controls the stress-activated Wak1-Wis1-Sty1 MAP kinase pathway and fission yeast cell cycle.

Shieh JC et al. Genes Dev 1997 Apr 15;11(8):1008-22

PMID:18257517 - Phosphoproteome analysis of fission yeast.

Wilson-Grady JT et al. J Proteome Res 2008 Mar;7(3):1088-97

PMID:10940030 - Spy1, a histidine-containing phosphotransfer signaling protein, regulates the fission yeast cell cycle through the Mcs4 response regulator.

Aoyama K et al. J Bacteriol 2000 Sep;182(17):4868-74

PMID:32915139 - Stress-activated MAPK signaling controls fission yeast actomyosin ring integrity by modulating formin For3 levels.

Gómez-Gil E et al. Elife 2020 Sep 11;9

PMID:1588914 - Five novel elements involved in the regulation of mitosis in fission yeast.

Warbrick E et al. Mol Gen Genet 1992 Apr;232(3):440-6

PMID:17559414 - Functional characterization of the phosphorelay protein Mpr1p from Schizosaccharomyces pombe.

Tan H et al. FEMS Yeast Res 2007 Sep;7(6):912-21

PMID:20946853 - Two-component signaling to the stress MAP kinase cascade in fission yeast.

Morigasaki S et al. Methods Enzymol 2010;471:279-89

PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.

Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514

PMID:22806344 - Genome-wide screen reveals novel mechanisms for regulating cobalt uptake and detoxification in fission yeast.

Ryuko S et al. Mol Genet Genomics 2012 Aug;287(8):651-62

PMID:11179424 - Peroxide sensors for the fission yeast stress-activated mitogen-activated protein kinase pathway.

Buck V et al. Mol Biol Cell 2001 Feb;12(2):407-19

PMID:23163955 - Analysis of stress-induced duplex destabilization (SIDD) properties of replication origins, genes and intergenes in the fission yeast, Schizosaccharomyces pombe.

Yadav MP et al. BMC Res Notes 2012 Nov 19;5:643

PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.

Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963

PMID:23389634 - Response regulator-mediated MAPKKK heteromer promotes stress signaling to the Spc1 MAPK in fission yeast.

Morigasaki S et al. Mol Biol Cell 2013 Apr;24(7):1083-92

PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.

Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.

UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531

PMID:9383051 - Mcs4, a two-component system response regulator homologue, regulates the Schizosaccharomyces pombe cell cycle control.

Cottarel G Genetics 1997 Nov;147(3):1043-51

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.

Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6

PMID:2474475 - cdc2 and the regulation of mitosis: six interacting mcs genes.

Molz L et al. Genetics 1989 Aug;122(4):773-82

PMID:9974219 - Enhancement of neutral trehalase activity by oxidative stress in the fission yeast Schizosaccharomyces pombe.

Fernández J et al. Fungal Genet Biol 1998 Nov;25(2):79-86

PMID:12596864 - His-to-Asp phosphorelay circuitry for regulation of sexual development in Schizosaccharomyces pombe.

Nakamichi N et al. Biosci Biotechnol Biochem 2002 Dec;66(12):2663-72

PMID:28974540 - The fission yeast nucleoporin Alm1 is required for proteasomal degradation of kinetochore components.

Salas-Pino S et al. J Cell Biol 2017 Nov 06;216(11):3591-3608

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:26567340 - Genome-wide Screening of Regulators of Catalase Expression: ROLE OF A TRANSCRIPTION COMPLEX AND HISTONE AND tRNA MODIFICATION COMPLEXES ON ADAPTATION TO STRESS.

García P et al. J Biol Chem 2016 Jan 08;291(2):790-9

PMID:9450957 - The Win1 mitotic regulator is a component of the fission yeast stress-activated Sty1 MAPK pathway.

Shieh JC et al. Mol Biol Cell 1998 Feb;9(2):311-22

PMID:23695164 - Cross-species protein interactome mapping reveals species-specific wiring of stress response pathways.

Das J et al. Sci Signal 2013 May 21;6(276):ra38

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:22144909 - The fission yeast stress-responsive MAPK pathway promotes meiosis via the phosphorylation of Pol II CTD in response to environmental and feedback cues.

Sukegawa Y et al. PLoS Genet 2011 Dec;7(12):e1002387

PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.

Strachan J et al. J Cell Sci 2023 Dec 01;136(23)

PMID:23271606 - Fission yeast TOR signaling is essential for the down-regulation of a hyperactivated stress-response MAP kinase under salt stress.

Ishiguro J et al. Mol Genet Genomics 2013 Feb;288(1-2):63-75

PMID:22661707 - A measurable activation of the bZIP transcription factor Atf1 in a fission yeast strain devoid of stress-activated and cell integrity mitogen-activated protein kinase (MAPK) activities.

Zhou X et al. J Biol Chem 2012 Jul 06;287(28):23434-9

PMID:26108447 - Azoles activate Atf1-mediated transcription through MAP kinase pathway for antifungal effects in fission yeast.

Hu L et al. Genes Cells 2015 Sep;20(9):695-705

PMID:25483073 - Chromosome segregation and organization are targets of 5'-Fluorouracil in eukaryotic cells.

Mojardín L et al. Cell Cycle 2015;14(2):206-18

PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.

Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160

PMID:37572670 - A peroxiredoxin-P38 MAPK scaffold increases MAPK activity by MAP3K-independent mechanisms.

Cao M et al. Mol Cell 2023 Sep 07;83(17):3140-3154.e7

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:19547744 - Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Beltrao P et al. PLoS Biol 2009 Jun 16;7(6):e1000134

PMID:19672306 - Genome-wide screen of genes required for caffeine tolerance in fission yeast.

Calvo IA et al. PLoS One 2009 Aug 12;4(8):e6619

PMID:18406331 - Glycolytic enzyme GAPDH promotes peroxide stress signaling through multistep phosphorelay to a MAPK cascade.

Morigasaki S et al. Mol Cell 2008 Apr 11;30(1):108-13

PMID:18931302 - Significant conservation of synthetic lethal genetic interaction networks between distantly related eukaryotes.

Dixon SJ et al. Proc Natl Acad Sci U S A 2008 Oct 28;105(43):16653-8

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.

Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87

PMID:16143612 - Schizosaccharomyces pombe adenylate cyclase suppressor mutations suggest a role for cAMP phosphodiesterase regulation in feedback control of glucose/cAMP signaling.

Wang L et al. Genetics 2005 Dec;171(4):1523-33

PMID:16087744 - Distinct signaling pathways respond to arsenite and reactive oxygen species in Schizosaccharomyces pombe.

Rodríguez-Gabriel MA et al. Eukaryot Cell 2005 Aug;4(8):1396-402

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:24255738 - Phosphorelay-dependent and -independent regulation of MAPKKK by the Mcs4 response regulator in fission yeast.

Morigasaki S et al. Commun Integr Biol 2013 Sep 01;6(5):e25020

PMID:27298342 - Identification of S-phase DNA damage-response targets in fission yeast reveals conservation of damage-response networks.

Willis NA et al. Proc Natl Acad Sci U S A 2016 Jun 28;113(26):E3676-85

PMID:20919928 - Two-component mediated peroxide sensing and signal transduction in fission yeast.

Quinn J et al. Antioxid Redox Signal 2011 Jul 01;15(1):153-65

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:35820914 - Antagonistic effects of mitochondrial matrix and intermembrane space proteases on yeast aging.

Vega M et al. BMC Biol 2022 Jul 12;20(1):160

PMID:10749922 - Multistep phosphorelay proteins transmit oxidative stress signals to the fission yeast stress-activated protein kinase.

Nguyen AN et al. Mol Biol Cell 2000 Apr;11(4):1169-81

PMID:29294138 - Editor's Highlight: A Genome-wide Screening of Target Genes Against Silver Nanoparticles in Fission Yeast.

Lee AR et al. Toxicol Sci 2018 Jan 01;161(1):171-185

PMID:22912829 - Response to arsenate treatment in Schizosaccharomyces pombe and the role of its arsenate reductase activity.

Salgado A et al. PLoS One 2012;7(8):e43208

PMID:18684775 - A genome-wide screen of genes involved in cadmium tolerance in Schizosaccharomyces pombe.

Kennedy PJ et al. Toxicol Sci 2008 Nov;106(1):124-39

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:31911490 - RNA-Binding Protein Rnc1 Regulates Cell Length at Division and Acute Stress Response in Fission Yeast through Negative Feedback Modulation of the Stress-Activated Mitogen-Activated Protein Kinase Pathway.

Prieto-Ruiz F et al. mBio 2020 Jan 07;11(1)

PMID:26412298 - A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Beckley JR et al. Mol Cell Proteomics 2015 Dec;14(12):3132-41

PMID:39476757 - Characterization of Ksg1 protein kinase-dependent phosphoproteome in the fission yeast S. pombe.

Cipak L et al. Biochem Biophys Res Commun 2024 Oct 25;736:150895

PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

Halova L et al. Open Biol 2021 Apr;11(4):200405