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protein coding gene - SPBC887.12 - P-type ATPase

Gene summary

Systematic ID
SPBC887.12
Product
P-type ATPase
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O94296
ORFeome ID
48/48E11
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome II: 3561697..3565982 forward strand

Annotation

PBO:0000222 - 3.6.3.1

Disease association

MONDO:0014104 - cerebellar ataxia, intellectual disability, and dysequilibrium syndrome 4

References:

MONDO:0001751 - cholestasis

References:

GO biological process

GO:0032456 - endocytic recycling

References:

GO:0045332 - phospholipid translocation

References:

GO:0006892 - post-Golgi vesicle-mediated transport

References:

GO cellular component

GO:0005783 - endoplasmic reticulum

References:

GO:0005886 - plasma membrane

References:

GO:0005802 - trans-Golgi network

References:

GO molecular function

GO:0005524 - ATP binding

References:

GO:0016887 - ATP hydrolysis activity

References:

GO:0000287 - magnesium ion binding

References:

GO:0070273 - phosphatidylinositol-4-phosphate binding

References:

GO:0140346 - phosphatidylserine flippase activity

References:

GO:0090556 - phosphatidylserine floppase activity

References:

Modification

MOD:00046 - O-phospho-L-serine

References:

MOD:00696 - phosphorylated residue

References:

MOD:01148 - ubiquitinylated lysine

References:

Protein sequence feature

SO:0001812 - transmembrane_helix

References:

Qualitative gene expression

PomGeneEx:0000018 - protein level increased

References:

PomGeneEx:0000011 - RNA level increased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0000059 - abnormal mitotic cell cycle

References:

Genotypes:

FYPO:0002251 - inviable swollen elongated vegetative cell

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0000750 - sensitive to silver ions

References:

Genotypes:

FYPO:0006929 - sensitive to silver nanoparticles

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF13246Cation_ATPasePFAM
PF16212PhoLip_ATPase_CP_typ_ATPase_cPFAM
PF16209PhoLip_ATPase_NP-type_ATPase_NPFAM
cd02073P-type_ATPase_APLT_Dnf-likeCDD
PS00154ATPASE_E1_E2ATPase_P-typ_P_sitePROSITE_PATTERNS
PR00119CATATPASEPRINTS
G3DSA:2.70.150.10:FF:000026FUNFAM
G3DSA:3.40.1110.10:FF:000087FUNFAM
G3DSA:3.40.50.1000:FF:000010FUNFAM
SSF81653Calcium ATPase, transduction domain AATPase_P-typ_transduc_dom_A_sfSUPERFAMILY
SSF56784HAD-likeHAD-like_sfSUPERFAMILY
SSF81665Calcium ATPase, transmembrane domain MATPase_P-typ_TM_dom_sfSUPERFAMILY
SSF81660Metal cation-transporting ATPase, ATP-binding domain NATPase_P-typ_cyto_dom_NSUPERFAMILY
G3DSA:3.40.1110.10ATPase_P-typ_cyto_dom_NGENE3D
G3DSA:2.70.150.10GENE3D
G3DSA:3.40.50.1000HAD_sfGENE3D
PTHR24092PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASEPANTHER
CoilCoilCOILS
mobidb-lite-Disorderdisorder_predictionMOBIDB-Disorder
mobidb-lite-Polardisorder_predictionMOBIDB-Polar
TIGR01652ATPase-PlipidP-type_ATPase_IVNCBIFAM
TIGR01494ATPase_P-typeP_typ_ATPaseNCBIFAM
SFLDS00003Haloacid_DehalogenaseSFLD
SFLDF00027p-type_atpaseP_typ_ATPase_HD_domSFLD
SFLDG00002C1.7:_P-type_atpase_likeSFLD

Orthologs

References / Literature

PMID:33109728 - High-Throughput Identification of Nuclear Envelope Protein Interactions in Schizosaccharomyces pombe Using an Arrayed Membrane Yeast-Two Hybrid Library.
Varberg JM et al. G3 (Bethesda) 2020 Dec 03;10(12):4649-4663
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:19547744 - Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.
Beltrao P et al. PLoS Biol 2009 Jun 16;7(6):e1000134
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:27298342 - Identification of S-phase DNA damage-response targets in fission yeast reveals conservation of damage-response networks.
Willis NA et al. Proc Natl Acad Sci U S A 2016 Jun 28;113(26):E3676-85
GO_REF:0000002 - Comments
PB_REF:0000003 - Disease Association Curation
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.
Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.
Halova L et al. Open Biol 2021 Apr;11(4):200405
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:34805795 - The fission yeast FLCN/FNIP complex augments TORC1 repression or activation in response to amino acid (AA) availability.
Calvo IA et al. iScience 2021 Nov 19;24(11):103338
PMID:29294138 - Editor's Highlight: A Genome-wide Screening of Target Genes Against Silver Nanoparticles in Fission Yeast.
Lee AR et al. Toxicol Sci 2018 Jan 01;161(1):171-185
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.
Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:18257517 - Phosphoproteome analysis of fission yeast.
Wilson-Grady JT et al. J Proteome Res 2008 Mar;7(3):1088-97
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.
Mata J et al. Nat Genet 2002 Sep;32(1):143-7