PomBase home

protein coding gene - cem1 (SPBC887.13c) - 3-oxoacyl-[acyl-carrier-protein]-synthase condensing enzyme Cem1

Gene summary

Standard name
cem1
Systematic ID
SPBC887.13c
Product
3-oxoacyl-[acyl-carrier-protein]-synthase condensing enzyme Cem1
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O94297
ORFeome ID
44/44C12
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome II: 3565749..3567340 reverse strand

Annotation

GO biological process

GO:0006633 - fatty acid biosynthetic process

References:

GO cellular component

GO:0005739 - mitochondrion

References:

GO molecular function

GO:0004315 - 3-oxoacyl-[acyl-carrier-protein] synthase activity

References:

Protein sequence feature

SO:0001808 - mitochondrial_targeting_signal

References:

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0004481 - abolished cell population growth at high temperature

References:

Genotypes:

FYPO:0000708 - decreased mating efficiency

References:

Genotypes:

FYPO:0000998 - elongated cell during nitrogen starvation

References:

Genotypes:

FYPO:0000650 - increased septation index

References:

Genotypes:

FYPO:0002148 - inviable after spore germination, multiple cell divisions, abnormal morphology

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0006660 - loss of viability upon G0 to G1 transition

References:

Genotypes:

FYPO:0003896 - normal mitochondrial morphology

References:

Genotypes:

FYPO:0000093 - sensitive to arsenic

References:

Genotypes:

FYPO:0001701 - sensitive to bortezomib

References:

Genotypes:

FYPO:0000096 - sensitive to cadmium

References:

Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF00109ketoacyl-syntKAS_NPfam
PF02801Ketoacyl-synt_CKAS_CPfam
cd00834KAS_I_IIBeta-ketoacyl_synthaseCDD
PS52004KS3_2PKS_Beta-ketoAc_synthase_domPROSITE profiles
SM00825PKS_KSPKS_Beta-ketoAc_synthase_domSMART
G3DSA:3.40.47.10:FF:000009CATH-FunFam
G3DSA:3.40.47.10Thiolase-likeCATH-Gene3D
SSF53901Thiolase-likeSUPERFAMILY
PTHR11712Beta-ketoacyl_synthasePANTHER
PIRSF000447KAS_II3-oxoacyl-ACP_synth-2PIRSF
NF005589PRK07314.1NCBIFAM
TIGR03150fabF3-oxoacyl-ACP_synth-2NCBIFAM

Orthologs

References / Literature

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:27558664 - Global Fitness Profiling Identifies Arsenic and Cadmium Tolerance Mechanisms in Fission Yeast.
Guo L et al. G3 (Bethesda) 2016 Oct 13;6(10):3317-3333
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:33823662 - Multiple nutritional phenotypes of fission yeast mutants defective in genes encoding essential mitochondrial proteins.
Uehara L et al. Open Biol 2021 Apr;11(4):200369
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:23950735 - Global analysis of fission yeast mating genes reveals new autophagy factors.
Sun LL et al. PLoS Genet 2013;9(8):e1003715
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:21760946 - Identification of genes affecting the toxicity of anti-cancer drug bortezomib by genome-wide screening in S. pombe.
Takeda K et al. PLoS One 2011;6(7):e22021