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protein coding gene - sfi1 (SPBC8D2.05c) - spindle pole body half bridge protein Sfi1

Gene summary

Standard name
sfi1
Systematic ID
SPBC8D2.05c
Product
spindle pole body half bridge protein Sfi1
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O13652
ORFeome ID
33/33H04
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 1366095..1368884 reverse strand

Annotation

GO biological process

GO:1903087 - mitotic spindle pole body duplication

References:

GO cellular component

GO:0005737 - cytoplasm

References:

GO:0005829 - cytosol

References:

GO:0061496 - half bridge of mitotic spindle pole body

References:

GO:0035974 - meiotic spindle pole body

References:

GO:0044732 - mitotic spindle pole body

References:

GO:0005634 - nucleus

References:

Modification

MOD:00046 - O-phospho-L-serine

References:

Protein features

PBO:0111918 - centrin binding repeats

References:

Qualitative gene expression

PomGeneEx:0000012 - RNA level decreased

References:

Quantitative gene expression

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0000059 - abnormal mitotic cell cycle

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Genotypes:

FYPO:0001490 - inviable elongated vegetative cell

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0001511 - inviable vegetative cell, abnormal cell shape, normal cell size

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011063 - conserved in fungi only

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF08457Sfi1Sfi1_domPfam
PTHR22028SFI1-likePANTHER

Orthologs

References / Literature

GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:28934593 - Big Lessons from Little Yeast: Budding and Fission Yeast Centrosome Structure, Duplication, and Function.
Cavanaugh AM et al. Annu Rev Genet 2017 Nov 27;51:361-383
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:22438582 - Spindle pole body components are reorganized during fission yeast meiosis.
Ohta M et al. Mol Biol Cell 2012 May;23(10):1799-811
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:28619713 - Molecular model of fission yeast centrosome assembly determined by superresolution imaging.
Bestul AJ et al. J Cell Biol 2017 Aug 07;216(8):2409-2424
PMID:10620777 - A 38 kb segment containing the cdc2 gene from the left arm of fission yeast chromosome II: sequence analysis and characterization of the genomic DNA and cDNAs encoded on the segment.
Machida M et al. Yeast 2000 Jan 15;16(1):71-80
PMID:30321377 - Proteomic profiling and functional characterization of post-translational modifications of the fission yeast RNA exosome.
Telekawa C et al. Nucleic Acids Res 2018 Nov 30;46(21):11169-11183
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:39471327 - New mutations in the core Schizosaccharomyces pombe spindle pole body scaffold Ppc89 reveal separable functions in regulating cell division.
Hanna SM et al. G3 (Bethesda) 2024 Oct 29;
PMID:26175449 - Monitoring SPB biogenesis in fission yeast with high resolution and quantitative fluorescent microscopy.
Bouhlel IB et al. Methods Cell Biol 2015;129:383-392
PMID:14504268 - Sfi1p has conserved centrin-binding sites and an essential function in budding yeast spindle pole body duplication.
Kilmartin JV J Cell Biol 2003 Sep 29;162(7):1211-21
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.
Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7