PomBase - protein coding gene - msl1 (SPBC8D2.09c) - U2 snRNP-associated protein Msl1 - The Schizosaccharomyces pombe genome database

ID	Name	InterPro name	DB name
PF00076	RRM_1	RRM_dom	PFAM
cd12246	RRM1_U1A_like		CDD
PS50102	RRM	RRM_dom	PROSITE_PROFILES
SM00360	rrm1_1	RRM_dom	SMART
G3DSA:3.30.70.330:FF:000572			FUNFAM
SSF54928	RNA-binding domain, RBD	RBD_domain_sf	SUPERFAMILY
G3DSA:3.30.70.330		Nucleotide-bd_a/b_plait_sf	GENE3D

References / Literature

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.: Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:28947618 - Sde2 is an intron-specific pre-mRNA splicing regulator activated by ubiquitin-like processing.: Thakran P et al. EMBO J 2018 Jan 04;37(1):89-101
PMID:15755920 - Dim1p is required for efficient splicing and export of mRNA encoding lid1p, a component of the fission yeast anaphase-promoting complex.: Carnahan RH et al. Eukaryot Cell 2005 Mar;4(3):577-87
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.: Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).: Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:25375137 - Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.: Hasan A et al. PLoS Genet 2014 Nov;10(11):e1004684
PMID:24713849 - Post-transcriptional regulation of meiotic genes by a nuclear RNA silencing complex.: Egan ED et al. RNA 2014 Jun;20(6):867-81
PMID:26292707 - Structure of a yeast spliceosome at 3.6-angstrom resolution.: Yan C et al. Science 2015 Sep 11;349(6253):1182-91
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.: Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.: Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.: Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80
PMID:31219728 - Identification of proteins associated with splicing factors Ntr1, Ntr2, Brr2 and Gpl1 in the fission yeast Schizosaccharomyces pombe .: Cipakova I et al. Cell Cycle 2019 Jul;18(14):1532-1536
PMID:36361590 - Defining the Functional Interactome of Spliceosome-Associated G-Patch Protein Gpl1 in the Fission Yeast Schizosaccharomyces pombe .: Selicky T et al. Int J Mol Sci 2022 Oct 24;23(21)
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.: Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:30355493 - Expanded Interactome of the Intrinsically Disordered Protein Dss1.: Schenstrøm SM et al. Cell Rep 2018 Oct 23;25(4):862-870
PMID:21511999 - Comparative functional genomics of the fission yeasts.: Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:28446597 - The histone variant H2A.Z promotes splicing of weak introns.: Nissen KE et al. Genes Dev 2017 Apr 01;31(7):688-701
PMID:21386897 - Systematic two-hybrid and comparative proteomic analyses reveal novel yeast pre-mRNA splicing factors connected to Prp19.: Ren L et al. PLoS One 2011 Feb 28;6(2):e16719
PMID:24014766 - Structural and functional characterization of the N terminus of Schizosaccharomyces pombe Cwf10.: Livesay SB et al. Eukaryot Cell 2013 Nov;12(11):1472-89
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.: Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:30759079 - A systematic genetic screen identifies essential factors involved in nuclear size control.: Cantwell H et al. PLoS Genet 2019 Feb;15(2):e1007929
PMID:11884590 - Proteomics analysis reveals stable multiprotein complexes in both fission and budding yeasts containing Myb-related Cdc5p/Cef1p, novel pre-mRNA splicing factors, and snRNAs.: Ohi MD et al. Mol Cell Biol 2002 Apr;22(7):2011-24
PMID:20118936 - Schizosaccharomyces pombe genome-wide nucleosome mapping reveals positioning mechanisms distinct from those of Saccharomyces cerevisiae.: Lantermann AB et al. Nat Struct Mol Biol 2010 Feb;17(2):251-7

protein coding gene - msl1 (SPBC8D2.09c) - U2 snRNP-associated protein Msl1

Gene summary

Annotation

GO biological process

GO:0045292 - mRNA cis splicing, via spliceosome

GO cellular component

GO:0005829 - cytosol

GO:0005634 - nucleus

GO:0005681 - spliceosomal complex

GO:0005686 - U2 snRNP

GO:0071004 - U2-type prespliceosome

GO molecular function

GO:0030620 - U2 snRNA binding

Modification

MOD:00046 - O-phospho-L-serine

Protein features

PBO:0111764 - rrm RNA recognition motif

Protein sequence feature

SO:0001812 - transmembrane_helix

Quantitative gene expression

PBO:0006310 - protein level

PBO:0011963 - RNA level

Single locus phenotype

FYPO:0000059 - abnormal mitotic cell cycle

FYPO:0006926 - increased nucleus:cytoplasm ratio

FYPO:0000314 - inviable after spore germination with elongated germ tube

FYPO:0003529 - inviable after spore germination, multiple cell divisions, cell cycle arrest in mitotic interphase, elongated cells

FYPO:0002061 - inviable vegetative cell population

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

Orthologs

References / Literature