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protein coding gene - sed5 (SPBC8D2.14c) - cis-Golgi t-SNARE Sed5

Gene summary

Standard name
sed5
Systematic ID
SPBC8D2.14c
Product
cis-Golgi t-SNARE Sed5
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O13644
ORFeome ID
32/32C11
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome II: 1381910..1385095 reverse strand

Annotation

Disease association

MONDO:0957540 - congenital disorder of glycosylation, type IIaa

References:

GO biological process

GO:0006888 - endoplasmic reticulum to Golgi vesicle-mediated transport

References:

GO:0006886 - intracellular protein transport

References:

GO:0006906 - vesicle fusion

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GO cellular component

GO:0005801 - cis-Golgi network

References:

GO:0000139 - Golgi membrane

References:

GO:0031201 - SNARE complex

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GO molecular function

GO:0005484 - SNAP receptor activity

References:

GO:0000149 - SNARE binding

References:

Protein features

PBO:0111768 - SNARE

Protein sequence feature

SO:0001812 - transmembrane_helix

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0002420 - inviable after spore germination, single cell division, abnormal cell shape

References:

Genotypes:

FYPO:0002151 - inviable spore

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF05739SNARET_SNARE_domPFAM
PF11416Syntaxin-5_NSyntaxin-5_NPFAM
cd15844SNARE_syntaxin5CDD
PS50192T_SNARET_SNARE_domPROSITE_PROFILES
SM00397tSNARE_6T_SNARE_domSMART
SSF47661t-snare proteinsSNARESUPERFAMILY
G3DSA:1.20.58.70GENE3D
PTHR19957SYNTAXINSyntaxinPANTHER
CoilCoilCOILS

Orthologs

References / Literature

PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.
Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.
Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PMID:20118936 - Schizosaccharomyces pombe genome-wide nucleosome mapping reveals positioning mechanisms distinct from those of Saccharomyces cerevisiae.
Lantermann AB et al. Nat Struct Mol Biol 2010 Feb;17(2):251-7
PMID:31474649 - Identification of 15 New Bypassable Essential Genes of Fission Yeast.
Takeda A et al. Cell Struct Funct 2019 Sep 27;44(2):113-119
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs