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protein coding gene - lip5 (SPBC8D2.15) - mitochondrial lipoic acid synthetase Lip5

Gene summary

Standard name
lip5
Systematic ID
SPBC8D2.15
Product
mitochondrial lipoic acid synthetase Lip5
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
SPNCRNA.347, SPNG1390
UniProt ID
O13642
ORFeome ID
32/32E10
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome II: 1386283..1387679 forward strand

Annotation

Disease association

MONDO:0013762 - lipoic acid synthetase deficiency

References:

GO biological process

GO:0009249 - protein lipoylation

References:

GO cellular component

GO:0005759 - mitochondrial matrix

References:

GO:0005739 - mitochondrion

References:

GO molecular function

GO:0051539 - 4 iron, 4 sulfur cluster binding

References:

GO:0016992 - lipoate synthase activity

References:

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0001511 - inviable vegetative cell, abnormal cell shape, normal cell size

References:

Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF04055Radical_SAMrSAMPfam
PF16881LIAS_NLIAS_NPfam
cd01335Radical_SAMCDD
PS51918RADICAL_SAMrSAMPROSITE profiles
SM00729Elp3Elp3/MiaA/NifB-like_rSAMSMART
G3DSA:3.20.20.70:FF:000036CATH-FunFam
G3DSA:3.20.20.70Aldolase_TIMCATH-Gene3D
SSF102114rSAM_sfSUPERFAMILY
PTHR10949Lipoyl_synthPANTHER
PIRSF005963Lipoyl_synthLipoyl_synthPIRSF
NF004019PRK05481.1NCBIFAM
NF009544PRK12928.1NCBIFAM
TIGR00510lipALipoyl_synthNCBIFAM
SFLDF00271lipoyl_synthaseLipoyl_synthSFLD
SFLDG01058lipoyl_synthase_likeSFLD
SFLDS00029Radical_SAMrSAMSFLD
MF_00206Lipoyl_synthLipoyl_synthHAMAP

Orthologs

References / Literature

PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.
Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
GO_REF:0000002 - Comments
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:30824696 - Systematic analysis reveals the prevalence and principles of bypassable gene essentiality.
Li J et al. Nat Commun 2019 Mar 01;10(1):1002
PMID:31474649 - Identification of 15 New Bypassable Essential Genes of Fission Yeast.
Takeda A et al. Cell Struct Funct 2019 Sep 27;44(2):113-119
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:35657410 - Loss of PPR protein Ppr2 induces ferroptosis-like cell death in Schizosaccharomyces pombe.
Liu Z et al. Arch Microbiol 2022 Jun 03;204(7):360