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protein coding gene - lip5 (SPBC8D2.15) - mitochondrial lipoic acid synthetase Lip5

Gene summary

Standard name
lip5
Systematic ID
SPBC8D2.15
Product
mitochondrial lipoic acid synthetase Lip5
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
SPNCRNA.347, SPNG1390
UniProt ID
O13642
ORFeome ID
32/32E10
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome II: 1386283..1387679 forward strand

Annotation

Disease association

MONDO:0013762 - lipoic acid synthetase deficiency

References:

GO biological process

GO:0009107 - lipoate biosynthetic process

References:

GO:0051604 - protein maturation

References:

GO cellular component

GO:0005739 - mitochondrion

References:

GO molecular function

GO:0051539 - 4 iron, 4 sulfur cluster binding

References:

GO:0016992 - lipoate synthase activity

References:

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0001511 - inviable vegetative cell, abnormal cell shape, normal cell size

References:

Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF16881LIAS_NLIAS_NPFAM
PF04055Radical_SAMrSAMPFAM
cd01335Radical_SAMCDD
PS51918RADICAL_SAMrSAMPROSITE_PROFILES
SM00729MiaBElp3/MiaA/NifB-like_rSAMSMART
G3DSA:3.20.20.70:FF:000036FUNFAM
SSF102114Radical SAM enzymesrSAM_sfSUPERFAMILY
G3DSA:3.20.20.70Aldolase class IAldolase_TIMGENE3D
PTHR10949LIPOYL SYNTHASELipoyl_synthPANTHER
PIRSF005963Lipoyl_synthLipoyl_synthPIRSF
MF_00206Lipoyl_synthLipoyl_synthHAMAP
NF009544PRK12928.1NCBIFAM
TIGR00510lipALipoyl_synthNCBIFAM
NF004019PRK05481.1NCBIFAM
SFLDG01058lipoyl_synthase_likeSFLD
SFLDF00271lipoyl_synthaseLipoyl_synthSFLD
SFLDS00029Radical_SAMrSAMSFLD

Orthologs

References / Literature

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:30824696 - Systematic analysis reveals the prevalence and principles of bypassable gene essentiality.
Li J et al. Nat Commun 2019 Mar 01;10(1):1002
GO_REF:0000051 - S. pombe keyword mapping
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:31474649 - Identification of 15 New Bypassable Essential Genes of Fission Yeast.
Takeda A et al. Cell Struct Funct 2019 Sep 27;44(2):113-119
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
GO_REF:0000002 - Comments
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:35657410 - Loss of PPR protein Ppr2 induces ferroptosis-like cell death in Schizosaccharomyces pombe.
Liu Z et al. Arch Microbiol 2022 Jun 03;204(7):360
PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.
Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963