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protein coding gene - SPBC8D2.16c - SPOUT family rRNA methyltransferase

Gene summary

Systematic ID
SPBC8D2.16c
Product
SPOUT family rRNA methyltransferase
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O13641
ORFeome ID
32/32C06
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome II: 1386312..1388881 reverse strand

Annotation

Disease association

MONDO:0976265 - neurodevelopmental disorder with poor growth, seizures, and brain abnormalities

References:

GO biological process

GO:0016072 - rRNA metabolic process

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GO cellular component

GO:0005829 - cytosol

References:

GO:0005730 - nucleolus

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GO:0005634 - nucleus

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GO molecular function

GO:0008173 - RNA methyltransferase activity

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Quantitative gene expression

PBO:0006310 - protein level

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PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0009038 - resistance to egtazic acid

References:

Genotypes:

FYPO:0001583 - resistance to lithium

References:

Genotypes:

FYPO:0001034 - resistance to tunicamycin

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Genotypes:

FYPO:0006680 - sensitive to bisphenol A

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Genotypes:

FYPO:0002701 - sensitive to torin1

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Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

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Genotypes:

Taxonomic conservation

PBO:0011072 - conserved in archaea

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF02598Methyltrn_RNA_3Put_MeTrfase-C9orf114-likePFAM
cd18086HsC9orf114-likePut_MeTrfase-C9orf114-likeCDD
G3DSA:2.40.50.140:FF:000170FUNFAM
SSF50249Nucleic acid-binding proteinsNA-bd_OB-foldSUPERFAMILY
SSF75217alpha/beta knotAlpha/beta_knot_MTasesSUPERFAMILY
G3DSA:3.40.1280.10tRNA_m1G_MTases_NGENE3D
G3DSA:2.40.50.140NA-bd_OB-foldGENE3D
PTHR12150CLASS IV SAM-BINDING METHYLTRANSFERASE-RELATEDPut_MeTrfase-C9orf114-likePANTHER

Orthologs

References / Literature

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:30647105 - Comparative Genomic Screen in Two Yeasts Reveals Conserved Pathways in the Response Network to Phenol Stress.
Alhoch B et al. G3 (Bethesda) 2019 Mar 07;9(3):639-650
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:18818364 - Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast.
Roguev A et al. Science 2008 Oct 17;322(5900):405-10
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
GO_REF:0000050 - Manual transfer of GO annotation data to genes by curator judgment of sequence model