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protein coding gene - frp2 (SPBC947.05c) - plasma membrane ferric reductase Frp2

Gene summary

Standard name
frp2
Systematic ID
SPBC947.05c
Product
plasma membrane ferric reductase Frp2
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O94727
ORFeome ID
35/35C12
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome II: 667125..668819 forward strand

Annotation

PBO:0003048 - 1.16.1.7

Disease association

MONDO:0010600 - granulomatous disease, chronic, X-linked

References:

MONDO:0010389 - X-linked Mendelian susceptibility to mycobacterial diseases due to CYBB deficiency

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GO biological process

GO:0010106 - cellular response to iron ion starvation

References:

GO:0033212 - iron import into cell

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GO cellular component

GO:0005886 - plasma membrane

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GO molecular function

GO:0050660 - flavin adenine dinucleotide binding

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GO:0005506 - iron ion binding

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GO:0016722 - oxidoreductase activity, acting on metal ions

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Modification

MOD:00006 - N-glycosylated residue

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Protein sequence feature

SO:0001812 - transmembrane_helix

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Qualitative gene expression

PomGeneEx:0000011 - RNA level increased

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Quantitative gene expression

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0000708 - decreased mating efficiency

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Genotypes:

FYPO:0003335 - increased galactose-specific flocculation

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Genotypes:

FYPO:0004344 - increased viability upon nitrogen starvation

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Genotypes:

FYPO:0001237 - normal growth on cadmium

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Genotypes:

FYPO:0003506 - normal growth on copper

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Genotypes:

FYPO:0006786 - normal growth on manganese

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Genotypes:

FYPO:0003507 - normal growth on zinc

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Genotypes:

FYPO:0000073 - resistance to caffeine

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Genotypes:

FYPO:0002634 - resistance to cobalt

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Genotypes:

FYPO:0000764 - resistance to cycloheximide

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Genotypes:

FYPO:0002693 - resistance to diamide

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Genotypes:

FYPO:0009038 - resistance to egtazic acid

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Genotypes:

FYPO:0001453 - resistance to ethanol

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Genotypes:

FYPO:0001583 - resistance to lithium

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Genotypes:

FYPO:0009083 - resistance to lithium chloride and methyl methanesulfonate

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Genotypes:

FYPO:0009085 - resistance to lithium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0009087 - resistance to magnesium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0000725 - resistance to methyl methanesulfonate

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Genotypes:

FYPO:0001034 - resistance to tunicamycin

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Genotypes:

FYPO:0009067 - sensitive to amorolfine

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Genotypes:

FYPO:0000096 - sensitive to cadmium

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Genotypes:

FYPO:0000799 - sensitive to diamide

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Genotypes:

FYPO:0000842 - sensitive to ethanol during vegetative growth

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Genotypes:

FYPO:0000087 - sensitive to hydrogen peroxide

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Genotypes:

FYPO:0005825 - sensitive to iron

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Genotypes:

FYPO:0007924 - sensitive to potassium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0000115 - sensitive to valproic acid

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Genotypes:

FYPO:0001234 - slow vegetative cell population growth

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

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Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

Protein features

IDNameInterPro nameDB name
PF08030NAD_binding_6Fe_red_NAD-bd_6PFAM
PF01794Ferric_reductFe3_Rdtase_TM_domPFAM
PF08022FAD_binding_8FAD-bd_8PFAM
cd06186NOX_Duox_like_FAD_NADPCDD
PS51384FAD_FRFAD-bd_FR_typePROSITE_PROFILES
PR00466GP91PHOXCyt_b245_heavy_chainPRINTS
G3DSA:3.40.50.80:FF:000074FUNFAM
SSF63380Riboflavin synthase domain-likeRiboflavin_synthase-like_b-brlSUPERFAMILY
SSF52343Ferredoxin reductase-like, C-terminal NADP-linked domainFNR_nucleotide-bdSUPERFAMILY
G3DSA:3.40.50.80FNR_nucleotide-bdGENE3D
PTHR32361FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENTFerric/Cupric_ReductasePANTHER
SFLDS00052Ferric_Reductase_DomainSFLD
SFLDG01168Ferric_reductase_subgroup_(FRSFLD
SFLDF00464Ferric/cupric_reductaseSFLD

Orthologs

References / Literature

PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.
Skribbe M et al. Mol Cell 2025 Feb 19;
PMID:22806344 - Genome-wide screen reveals novel mechanisms for regulating cobalt uptake and detoxification in fission yeast.
Ryuko S et al. Mol Genet Genomics 2012 Aug;287(8):651-62
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:28410370 - A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.
Dudin O et al. PLoS Genet 2017 Apr;13(4):e1006721
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:34984977 - Functional profiling of long intergenic non-coding RNAs in fission yeast.
Rodriguez-Lopez M et al. Elife 2022 Jan 05;11
PMID:25452419 - Parallel profiling of fission yeast deletion mutants for proliferation and for lifespan during long-term quiescence.
Sideri T et al. G3 (Bethesda) 2014 Dec 01;5(1):145-55
GO_REF:0000050 - Manual transfer of GO annotation data to genes by curator judgment of sequence model
PMID:29878109 - Disruption of ppr3, ppr4, ppr6 or ppr10 induces flocculation and filamentous growth in Schizosaccharomyces pombe.
Su Y et al. FEMS Microbiol Lett 2018 Aug 01;365(16)
PMID:30393157 - Overexpression of Schizosaccharomyces pombe tRNA 3'-end processing enzyme Trz2 leads to an increased cellular iron level and apoptotic cell death.
Shang J et al. Fungal Genet Biol 2019 Jan;122:11-20
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
PMID:17477863 - Global transcriptional responses of fission and budding yeast to changes in copper and iron levels: a comparative study.
Rustici G et al. Genome Biol 2007;8(5):R73
PMID:26896847 - Ensembl comparative genomics resources.
Herrero J et al. Database (Oxford) 2016;2016
PMID:27886462 - Loss of ppr3, ppr4, ppr6, or ppr10 perturbs iron homeostasis and leads to apoptotic cell death in Schizosaccharomyces pombe.
Su Y et al. FEBS J 2017 Jan;284(2):324-337
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
GO_REF:0000117 - Electronic Gene Ontology annotations created by ARBA machine learning models
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.
Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:34967420 - Genetic screen for suppression of transcriptional interference reveals fission yeast 14-3-3 protein Rad24 as an antagonist of precocious Pol2 transcription termination.
Garg A et al. Nucleic Acids Res 2022 Jan 25;50(2):803-819
PMID:35079912 - Identification and analysis of iron transporters from the fission yeast Schizosaccharomyces pombe.
Ahmad F et al. Arch Microbiol 2022 Jan 26;204(2):152
PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.
Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531