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protein coding gene - kms2 (SPBC947.12) - mitotic and meiotic spindle pole body KASH domain protein Kms2

Gene summary

Standard name
kms2
Systematic ID
SPBC947.12
Product
mitotic and meiotic spindle pole body KASH domain protein Kms2
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O43087
ORFeome ID
23/23H09
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 646936..649019 reverse strand

Annotation

Disease association

MONDO:0014237 - autosomal recessive nonsyndromic hearing loss 76

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GO biological process

GO:1903087 - mitotic spindle pole body duplication

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GO:0140480 - mitotic spindle pole body insertion into the nuclear envelope

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GO cellular component

GO:0005737 - cytoplasm

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GO:0061496 - half bridge of mitotic spindle pole body

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GO:0034993 - meiotic nuclear membrane microtubule tethering complex

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GO:0044732 - mitotic spindle pole body

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GO:0005634 - nucleus

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GO:0071957 - old mitotic spindle pole body

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GO molecular function

GO:0106166 - spindle pole body-nuclear membrane anchor activity

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Modification

MOD:00046 - O-phospho-L-serine

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MOD:00047 - O-phospho-L-threonine

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MOD:00048 - O4'-phospho-L-tyrosine

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Multi-locus phenotype

FYPO:0001357 - normal vegetative cell population growth

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Genotypes:

Protein features

PBO:0111761 - EF hand

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PBO:0111886 - KASH domain protein

Protein sequence feature

SO:0001812 - transmembrane_helix

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Qualitative gene expression

PomGeneEx:0000011 - RNA level increased

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Quantitative gene expression

PBO:0006310 - protein level

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PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0003569 - abnormal mitotic spindle pole body insertion into nuclear envelope, with spindle pole body in cytoplasm

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Genotypes:

FYPO:0003568 - abnormal mitotic spindle pole body insertion into nuclear envelope, with spindle pole body in nucleoplasm

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Genotypes:

FYPO:0000769 - abnormal nuclear envelope morphology during vegetative growth

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Genotypes:

FYPO:0000227 - chromosome loss during mitotic chromosome segregation

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Genotypes:

FYPO:0000940 - decreased protein localization to mitotic spindle pole body

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Genotypes:

FYPO:0002636 - delayed onset of mitotic spindle elongation

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Genotypes:

FYPO:0003566 - delayed onset of mitotic spindle pole body separation

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Genotypes:

FYPO:0001837 - increased duration of protein localization to mitotic spindle pole body

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Genotypes:

FYPO:0006926 - increased nucleus:cytoplasm ratio

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Genotypes:

FYPO:0002969 - increased protein localization to mitotic spindle pole body

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Genotypes:

FYPO:0003529 - inviable after spore germination, multiple cell divisions, cell cycle arrest in mitotic interphase, elongated cells

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Genotypes:

FYPO:0002379 - inviable after spore germination, without cell division, with elongated germ tube

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Genotypes:

FYPO:0002151 - inviable spore

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Genotypes:

FYPO:0002061 - inviable vegetative cell population

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Genotypes:

FYPO:0000012 - mitotic G2/M phase transition delay

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Genotypes:

FYPO:0002688 - mitotic spindle collapse without elongation during prophase

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Genotypes:

FYPO:0000276 - monopolar mitotic spindle

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Genotypes:

FYPO:0000732 - short bipolar mitotic spindle

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Genotypes:

FYPO:0003481 - viable elongated vegetative cell, elongated upon mitotic entry

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Genotypes:

FYPO:0001491 - viable vegetative cell

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0000055 - no apparent S. cerevisiae ortholog

Protein features

IDNameInterPro nameDB name
PTHR21640SYNE4PANTHER
Transmembrane alpha helixDeepTMHMM
CoilCOILS

Orthologs

References / Literature

PMID:23163955 - Analysis of stress-induced duplex destabilization (SIDD) properties of replication origins, genes and intergenes in the fission yeast, Schizosaccharomyces pombe.
Yadav MP et al. BMC Res Notes 2012 Nov 19;5:643
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.
Halova L et al. Open Biol 2021 Apr;11(4):200405
PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.
Mata J et al. Nat Genet 2002 Sep;32(1):143-7
PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.
Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:22042620 - Brr6 drives the Schizosaccharomyces pombe spindle pole body nuclear envelope insertion/extrusion cycle.
Tamm T et al. J Cell Biol 2011 Oct 31;195(3):467-84
PMID:30759079 - A systematic genetic screen identifies essential factors involved in nuclear size control.
Cantwell H et al. PLoS Genet 2019 Feb;15(2):e1007929
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:37783794 - An ESCRT grommet cooperates with a diffusion barrier to maintain nuclear integrity.
Ader NR et al. Nat Cell Biol 2023 Oct;25(10):1465-1477
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:10759889 - Large-scale screening of intracellular protein localization in living fission yeast cells by the use of a GFP-fusion genomic DNA library.
Ding DQ et al. Genes Cells 2000 Mar;5(3):169-90
PMID:39476757 - Characterization of Ksg1 protein kinase-dependent phosphoproteome in the fission yeast S. pombe.
Cipak L et al. Biochem Biophys Res Commun 2024 Oct 25;736:150895
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:18257517 - Phosphoproteome analysis of fission yeast.
Wilson-Grady JT et al. J Proteome Res 2008 Mar;7(3):1088-97
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:22907753 - Posttranscriptional regulation of cell-cell interaction protein-encoding transcripts by Zfs1p in Schizosaccharomyces pombe.
Wells ML et al. Mol Cell Biol 2012 Oct;32(20):4206-14
PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.
Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6
PMID:14655046 - Two-hybrid search for proteins that interact with Sad1 and Kms1, two membrane-bound components of the spindle pole body in fission yeast.
Miki F et al. Mol Genet Genomics 2004 Jan;270(6):449-61
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:28619713 - Molecular model of fission yeast centrosome assembly determined by superresolution imaging.
Bestul AJ et al. J Cell Biol 2017 Aug 07;216(8):2409-2424
PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.
Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514
PMID:34133218 - Redistribution of centrosomal proteins by centromeres and Polo kinase controls partial nuclear envelope breakdown in fission yeast.
Bestul AJ et al. Mol Biol Cell 2021 Aug 01;32(16):1487-1500
PMID:21340088 - Microarray-based target identification using drug hypersensitive fission yeast expressing ORFeome.
Arita Y et al. Mol Biosyst 2011 May;7(5):1463-72
PMID:24963130 - The KASH protein Kms2 coordinates mitotic remodeling of the spindle pole body.
Wälde S et al. J Cell Sci 2014 Aug 15;127(Pt 16):3625-40
PMID:27984725 - CDK Substrate Phosphorylation and Ordering the Cell Cycle.
Swaffer MP et al. Cell 2016 Dec 15;167(7):1750-1761.e16
PMID:22425159 - Transient structure associated with the spindle pole body directs meiotic microtubule reorganization in S. pombe.
Funaya C et al. Curr Biol 2012 Apr 10;22(7):562-74