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protein coding gene - mdl1 (SPBC9B6.09c) - mitochondrial peptide-transporting ATPase

Gene summary

Standard name
mdl1
Systematic ID
SPBC9B6.09c
Product
mitochondrial peptide-transporting ATPase
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q9Y7M7
ORFeome ID
37/37G12
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 1828456..1831050 reverse strand

Annotation

GO biological process

GO:0090374 - oligopeptide export from mitochondrion

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GO cellular component

GO:0005743 - mitochondrial inner membrane

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GO:0005739 - mitochondrion

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GO molecular function

GO:0015421 - ABC-type oligopeptide transporter activity

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GO:0005524 - ATP binding

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GO:0016887 - ATP hydrolysis activity

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Modification

MOD:00006 - N-glycosylated residue

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Protein features

PBO:0111874 - ABC transporter family

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Protein sequence feature

SO:0001808 - mitochondrial_targeting_signal

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SO:0001812 - transmembrane_helix

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Quantitative gene expression

PBO:0006310 - protein level

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PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0002061 - inviable vegetative cell population

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Genotypes:

FYPO:0004295 - multiseptate cell

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Genotypes:

FYPO:0003849 - normal growth on fluconazole

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Genotypes:

FYPO:0003852 - normal growth on FR901464

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Genotypes:

FYPO:0000979 - normal growth on miconazole

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Genotypes:

FYPO:0003851 - normal growth on MTT

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Genotypes:

FYPO:0003850 - normal growth on oligomycin

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Genotypes:

FYPO:0003719 - normal growth on tributyltin

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Genotypes:

FYPO:0002693 - resistance to diamide

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Genotypes:

FYPO:0001453 - resistance to ethanol

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Genotypes:

FYPO:0001103 - resistance to hydrogen peroxide

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Genotypes:

FYPO:0003383 - resistance to tert-butyl hydroperoxide

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Genotypes:

FYPO:0000327 - resistance to trichostatin A

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Genotypes:

FYPO:0002237 - sensitive to cerulenin

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Genotypes:

FYPO:0007931 - sensitive to egtazic acid

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

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Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF00664ABC_membraneABC1_TM_domPFAM
PF00005ABC_tranABC_transporter-like_ATP-bdPFAM
cd18573ABC_6TM_ABCB10_likeCDD
PS00211ABC_TRANSPORTER_1ABC_transporter-like_CSPROSITE_PATTERNS
PS50893ABC_TRANSPORTER_2ABC_transporter-like_ATP-bdPROSITE_PROFILES
PS50929ABC_TM1FABC1_TM_domPROSITE_PROFILES
SM00382AAA_5AAA+_ATPaseSMART
G3DSA:1.20.1560.10:FF:000085FUNFAM
G3DSA:3.40.50.300:FF:000836FUNFAM
SSF52540P-loop containing nucleoside triphosphate hydrolasesP-loop_NTPaseSUPERFAMILY
SSF90123ABC transporter transmembrane regionABC1_TM_sfSUPERFAMILY
G3DSA:1.20.1560.10ABC transporter type 1, transmembrane domainABC1_TM_sfGENE3D
G3DSA:3.40.50.300P-loop_NTPaseGENE3D
PTHR43394ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIALType_1_exporterPANTHER
PIRSF002773ABC_prm/ATPase_BPIRSF

Orthologs

References / Literature

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:16849797 - A survey of all 11 ABC transporters in fission yeast: two novel ABC transporters are required for red pigment accumulation in a Schizosaccharomyces pombe adenine biosynthetic mutant.
Iwaki T et al. Microbiology (Reading) 2006 Aug;152(Pt 8):2309-2321
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
GO_REF:0000002 - Comments
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:28410370 - A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.
Dudin O et al. PLoS Genet 2017 Apr;13(4):e1006721
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
PMID:21340088 - Microarray-based target identification using drug hypersensitive fission yeast expressing ORFeome.
Arita Y et al. Mol Biosyst 2011 May;7(5):1463-72
PMID:22907753 - Posttranscriptional regulation of cell-cell interaction protein-encoding transcripts by Zfs1p in Schizosaccharomyces pombe.
Wells ML et al. Mol Cell Biol 2012 Oct;32(20):4206-14
PMID:21297349 - Bfr1p is responsible for tributyltin resistance in Schizosaccharomyces pombe.
Akiyama K et al. J Toxicol Sci 2011 Jan;36(1):117-20
PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.
Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7