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protein coding gene - pgs1 (SPBP18G5.02) - CDP-diacylglycerol-glycerol-3-phosphate3-phosphatidyltransferase Pgs1

Gene summary

Standard name
pgs1
Systematic ID
SPBP18G5.02
Product
CDP-diacylglycerol-glycerol-3-phosphate3-phosphatidyltransferase Pgs1
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q9HDW1
ORFeome ID
49/49A11
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 2401753..2403432 forward strand

Annotation

PBO:0004041 - 2.7.8.5

GO biological process

GO:0032049 - cardiolipin biosynthetic process

References:

GO:0016024 - CDP-diacylglycerol biosynthetic process

References:

GO:0007006 - mitochondrial membrane organization

References:

GO cellular component

GO:0005759 - mitochondrial matrix

References:

GO:0031966 - mitochondrial membrane

References:

GO molecular function

GO:0008444 - CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity

References:

Qualitative gene expression

PomGeneEx:0000018 - protein level increased

References:

PomGeneEx:0000012 - RNA level decreased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0002111 - inviable tapered vegetative cell

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Warnings

PBO:0000070 - gene structure updated

References:

Protein features

IDNameInterPro nameDB name
cd09135PLDc_PGS1_euk_1CDD
cd09137PLDc_PGS1_euk_2CDD
SM00155PLDcPLipase_D/transphosphatidylaseSMART
G3DSA:3.30.870.10:FF:000044CATH-FunFam
G3DSA:3.30.870.10:FF:000046CATH-FunFam
G3DSA:3.30.870.10CATH-Gene3D
SSF56024SUPERFAMILY
PTHR12586PGS1PANTHER
PIRSF000850Phospholipase_D_PSSPIRSF

Orthologs

References / Literature

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:9468529 - Purification and characterization of phosphatidylglycerolphosphate synthase from Schizosaccharomyces pombe.
Jiang F et al. J Biol Chem 1998 Feb 20;273(8):4681-8
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:1324908 - Regulation of CDP-diacylglycerol synthesis and utilization by inositol and choline in Schizosaccharomyces pombe.
Gaynor PM et al. J Bacteriol 1992 Sep;174(17):5711-8
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:28218250 - Chromatin remodeller Fun30 Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.
Lee J et al. Nat Commun 2017 Feb 20;8:14527
PMID:31474649 - Identification of 15 New Bypassable Essential Genes of Fission Yeast.
Takeda A et al. Cell Struct Funct 2019 Sep 27;44(2):113-119
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053