protein coding gene - gcv3 (SPBP19A11.01) - glycine cleavage complex subunit H, Gcv3

Gene summary

Standard name: gcv3
Systematic ID: SPBP19A11.01
Product: glycine cleavage complex subunit H, Gcv3
Organism: Schizosaccharomyces pombe (fission yeast)
UniProt ID: Q9HDV9
ORFeome ID: 41/41C12
Characterisation status: biological role inferred
Feature type: mRNA gene
Genomic location: chromosome II: 2848474..2849481 forward strand

Annotation

Disease association

MONDO:0011612 - glycine encephalopathy

References:

PB_REF:0000003

MONDO:0004736 - inborn disorder of amino acid metabolism

References:

PB_REF:0000003

MONDO:0005066 - metabolic disease

References:

PB_REF:0000003

MONDO:0957382 - multiple mitochondrial dysfunctions syndrome 7

References:

PB_REF:0000006

GO biological process

GO:0019464 - glycine decarboxylation via glycine cleavage system

References:

GO_REF:0000033

GO cellular component

GO:0005960 - glycine cleavage complex

References:

GO_REF:0000033

GO:0005759 - mitochondrial matrix

References:

GO_REF:0000036

GO:0005739 - mitochondrion

References:

PMID:16823372

GO molecular function

GO:0140104 - molecular carrier activity

References:

GO_REF:0000051

Modification

MOD:00127 - N6-lipoyl-L-lysine

References:

MOD:00046 - O-phospho-L-serine

References:

Protein sequence feature

SO:0001808 - mitochondrial_targeting_signal

References:

PMID:36408920

Qualitative gene expression

PomGeneEx:0000018 - protein level increased

References:

PMID:39367033

PomGeneEx:0000012 - RNA level decreased

References:

PMID:27984744

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

PMID:23101633

Single locus phenotype

FYPO:0000314 - inviable after spore germination with elongated germ tube

References:

PMID:23697806

Genotypes:

gcv3delta

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

gcv3delta

FYPO:0002451 - inviable vegetative cell with abnormal cell shape

References:

PMID:23697806

Genotypes:

gcv3delta

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

ID	Name	InterPro name	DB name
PF01597	GCV_H	GCV_H/Fam206	PFAM
cd06848	GCS_H	GCV_H/Fam206	CDD
PS50968	BIOTINYL_LIPOYL	Biotin_lipoyl	PROSITE_PROFILES
SSF51230	Single hybrid motif	Single_hybrid_motif	SUPERFAMILY
G3DSA:2.40.50.100			GENE3D
PTHR11715	GLYCINE CLEAVAGE SYSTEM H PROTEIN	GCV_H	PANTHER
MF_00272	GcvH	GCV_H	HAMAP
TIGR00527	gcvH	GCV_H_sub	NCBIFAM
NF002270	PRK01202.1		NCBIFAM

Orthologs

GCSH (HGNC:4208) Homo sapiens
gcv3 (SJAG_03641) Schizosaccharomyces japonicus
GCV3 (YAL044C) Saccharomyces cerevisiae

References / Literature

GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.: Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.: UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.: Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.: Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PB_REF:0000001 - Protein modification annotation by manual transfer of experimentally-verified annotation data to orthologs based on curator judgment of sequence features.
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.: Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:21511999 - Comparative functional genomics of the fission yeasts.: Rhind N et al. Science 2011 May 20;332(6032):930-6
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.: Hayles J et al. Open Biol 2013 May 22;3(5):130053
GO_REF:0000051 - S. pombe keyword mapping
GO_REF:0000036 - Manual annotations that require more than one source of functional data to support the assignment of the associated GO term
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).: Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.: Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.: Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PB_REF:0000003 - Disease Association Curation
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.: Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.: Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:31474649 - Identification of 15 New Bypassable Essential Genes of Fission Yeast.: Takeda A et al. Cell Struct Funct 2019 Sep 27;44(2):113-119
PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.: Halova L et al. Open Biol 2021 Apr;11(4):200405