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protein coding gene - hid2 (SPBP19A11.07c) - HID1 domain-containing protein, Hid2

Gene summary

Standard name
hid2
Systematic ID
SPBP19A11.07c
Product
HID1 domain-containing protein, Hid2
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
SPBP4H10.02c, SPBC1346.03
UniProt ID
Q9HDV3
ORFeome ID
28/28F11
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 2868413..2871090 reverse strand

Annotation

Disease association

MONDO:0031028 - developmental and epileptic encephalopathy 105 with hypopituitarism

References:

GO biological process

GO:0007030 - Golgi organization

References:

GO cellular component

GO:0005829 - cytosol

References:

GO:0005797 - Golgi medial cisterna

References:

GO:0000138 - Golgi trans cisterna

References:

GO:0016020 - membrane

References:

GO:0005634 - nucleus

References:

Modification

MOD:00046 - O-phospho-L-serine

References:

MOD:01148 - ubiquitinylated lysine

References:

Qualitative gene expression

PomGeneEx:0000018 - protein level increased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

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Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Warnings

PBO:0000070 - gene structure updated

References:

Protein features

IDNameInterPro nameDB name
PF12722Hid1HID1/Ecm30PFAM
PTHR21575PROTEIN HID1HID1/Ecm30PANTHER

Orthologs

References / Literature

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:20118936 - Schizosaccharomyces pombe genome-wide nucleosome mapping reveals positioning mechanisms distinct from those of Saccharomyces cerevisiae.
Lantermann AB et al. Nat Struct Mol Biol 2010 Feb;17(2):251-7
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:40899782 - Golgi_traff phylogeny reveals ancient eukaryotic genes with recent surprises: replication and diversification of HID1 Domain-Containing Protein unique to Schizosaccharomyces.
Hooks MA et al. FEMS Microbiol Lett 2025 Sep 03;