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protein coding gene - sbg1 (SPBP22H7.03) - plasma membrane-actinomyosin ring linker protein Sbg1

Gene summary

Standard name
sbg1
Systematic ID
SPBP22H7.03
Product
plasma membrane-actinomyosin ring linker protein Sbg1
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
pi028, SPACTOKYO_453.06c, SPACTOKYO_453.07
UniProt ID
O13619
ORFeome ID
41/41D02
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 1436237..1437475 forward strand

Annotation

GO biological process

GO:0140278 - mitotic division septum assembly

References:

GO cellular component

GO:0051285 - cell cortex of cell tip

References:

GO:0032153 - cell division site

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GO:0005737 - cytoplasm

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GO:0000935 - division septum

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GO:0005886 - plasma membrane

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GO molecular function

GO:0030674 - protein-macromolecule adaptor activity

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Protein sequence feature

SO:0001812 - transmembrane_helix

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Quantitative gene expression

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0001585 - abolished protein localization to cell tip during vegetative growth

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Genotypes:

FYPO:0003205 - decreased primary cell septum thickness

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Genotypes:

FYPO:0001324 - decreased protein level during vegetative growth

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Genotypes:

FYPO:0002869 - decreased protein localization to cell division site

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Genotypes:

FYPO:0002719 - decreased protein localization to septum

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Genotypes:

FYPO:0001365 - decreased rate of actomyosin contractile ring contraction

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Genotypes:

FYPO:0004653 - delayed onset of actomyosin contractile ring contraction

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Genotypes:

FYPO:0005872 - incomplete septum formed from asymmetrically located sites

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Genotypes:

FYPO:0001035 - increased cell wall thickness during vegetative growth

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Genotypes:

FYPO:0005873 - increased secondary cell septum thickness

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Genotypes:

FYPO:0005469 - inviable after spore germination, without cell division, lysed cell

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Genotypes:

FYPO:0002423 - inviable after spore germination, without cell division, septated cells with abnormal cell shape

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Genotypes:

FYPO:0002515 - inviable after spore germination, without cell division, with branched, elongated germ tube

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Genotypes:

FYPO:0003005 - inviable after spore germination, without cell division, with swollen, branched, elongated germ tube

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Genotypes:

FYPO:0005869 - inviable stubby multiseptate vegetative cell

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Genotypes:

FYPO:0002200 - inviable stubby septated vegetative cell

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Genotypes:

FYPO:0002107 - inviable stubby vegetative cell

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Genotypes:

FYPO:0002061 - inviable vegetative cell population

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Genotypes:

FYPO:0001369 - mislocalized actomyosin contractile ring

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Genotypes:

FYPO:0001368 - normal actomyosin contractile ring assembly

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Genotypes:

FYPO:0003627 - normal protein localization

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Genotypes:

FYPO:0002442 - normal protein localization to cell division site

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Genotypes:

FYPO:0005871 - thin, incomplete primary cell septum

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Genotypes:

Taxonomic conservation

PBO:0011064 - conserved in fungi

PBO:0011063 - conserved in fungi only

Protein features

IDNameInterPro nameDB name
mobidb-lite-Disorderdisorder_predictionMOBIDB-Disorder
mobidb-lite-Negative-Polyelectrolytedisorder_predictionMOBIDB-Negative-Polyelectrolyte

Orthologs

References / Literature

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:34910579 - Involvement of Smi1 in cell wall integrity and glucan synthase Bgs4 localization during fission yeast cytokinesis.
Longo LVG et al. Mol Biol Cell 2022 Feb 01;33(2):ar17
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:27898700 - Sbg1 Is a Novel Regulator for the Localization of the β-Glucan Synthase Bgs1 in Fission Yeast.
Davidson R et al. PLoS One 2016;11(11):e0167043
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:20118936 - Schizosaccharomyces pombe genome-wide nucleosome mapping reveals positioning mechanisms distinct from those of Saccharomyces cerevisiae.
Lantermann AB et al. Nat Struct Mol Biol 2010 Feb;17(2):251-7
PMID:27749909 - A New Membrane Protein Sbg1 Links the Contractile Ring Apparatus and Septum Synthesis Machinery in Fission Yeast.
Sethi K et al. PLoS Genet 2016 Oct;12(10):e1006383
PMID:25375137 - Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.
Hasan A et al. PLoS Genet 2014 Nov;10(11):e1004684
PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.
Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623