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protein coding gene - sdh7 (SPBP23A10.03c) - mitochondrial respiratory chain complex II assembly LYR family protein Sdh7

Gene summary

Standard name
sdh7
Systematic ID
SPBP23A10.03c
Product
mitochondrial respiratory chain complex II assembly LYR family protein Sdh7
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q9P7Y2
ORFeome ID
04/04B12
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome II: 1999257..2000839 reverse strand

Annotation

Disease association

MONDO:0000448 - paraganglioma

References:

MONDO:0008233 - pheochromocytoma

References:

GO biological process

GO:0034553 - mitochondrial respiratory chain complex II assembly

References:

GO cellular component

GO:0005739 - mitochondrion

References:

Protein features

PBO:0111754 - LYR family

Protein sequence feature

SO:0001808 - mitochondrial_targeting_signal

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0001491 - viable vegetative cell

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Warnings

PBO:0001756 - protein coding overlap with adjacent gene

Protein features

IDNameInterPro nameDB name
PF13233Complex1_LYR_2PFAM
cd20270Complex1_LYR_SDHAF3_LYRM10CDD
PTHR13137DC11 ACN9 HOMOLOGSDHAF3/Sdh7PANTHER

Orthologs

References / Literature

GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:28738844 - Analysis of SDHAF3 in familial and sporadic pheochromocytoma and paraganglioma.
Dwight T et al. BMC Cancer 2017 Jul 24;17(1):497
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
PMID:17614284 - The chromatin-remodeling factor FACT contributes to centromeric heterochromatin independently of RNAi.
Lejeune E et al. Curr Biol 2007 Jul 17;17(14):1219-24
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:27168121 - Discovery of genes involved in mitosis, cell division, cell wall integrity and chromosome segregation through construction of Schizosaccharomyces pombe deletion strains.
Chen JS et al. Yeast 2016 Sep;33(9):507-17