protein coding gene - apc2 (SPBP23A10.04) - anaphase-promoting complex cullin family subunit Apc2

Gene summary

Standard name: apc2
Systematic ID: SPBP23A10.04
Product: anaphase-promoting complex cullin family subunit Apc2
Organism: Schizosaccharomyces pombe (fission yeast)
UniProt ID: Q874R3
ORFeome ID: 37/37E02
Characterisation status: biological role published
Feature type: mRNA gene
Genomic location: chromosome II: 2000909..2003598 forward strand

Annotation

GO biological process

GO:0007091 - metaphase/anaphase transition of mitotic cell cycle

References:

GO_REF:0000033

GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process

References:

PMID:12477395

GO cellular component

GO:0005680 - anaphase-promoting complex

References:

GO:0005829 - cytosol

References:

PMID:16823372

GO:0005634 - nucleus

References:

PMID:16823372

Qualitative gene expression

PomGeneEx:0000011 - RNA level increased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

PMID:23101633

Single locus phenotype

FYPO:0000059 - abnormal mitotic cell cycle

References:

PMID:23697806

Genotypes:

apc2delta

FYPO:0001490 - inviable elongated vegetative cell

References:

PMID:23697806

Genotypes:

apc2delta

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

apc2delta

FYPO:0001511 - inviable vegetative cell, abnormal cell shape, normal cell size

References:

PMID:23697806

Genotypes:

apc2delta

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

ID	Name	InterPro name	DB name
PF26557	Cullin_AB	Cullin-like_AB	PFAM
PF08672	ANAPC2	ANAPC2_C	PFAM
PF25773	TPR_ANAPC2	TPR_ANAPC2	PFAM
PS50069	CULLIN_2	Cullin_homology	PROSITE_PROFILES
SM01013	APC2_2	ANAPC2_C	SMART
SM00182	cul_2	Cullin_homology	SMART
G3DSA:1.10.10.10:FF:000331			FUNFAM
G3DSA:1.20.1310.10:FF:000033			FUNFAM
SSF46785	"Winged helix" DNA-binding domain	WH_DNA-bd_sf	SUPERFAMILY
SSF75632	Cullin homology domain	Cullin_homology_sf	SUPERFAMILY
G3DSA:3.30.230.130	Cullin; Chain C, Domain 2		GENE3D
G3DSA:1.10.10.10		WH-like_DNA-bd_sf	GENE3D
G3DSA:1.20.1310.10	Cullin Repeats		GENE3D
PTHR45957	ANAPHASE-PROMOTING COMPLEX SUBUNIT 2	ANAPC2	PANTHER

Orthologs

ANAPC2 (HGNC:19989) Homo sapiens
apc2 (SJAG_03575) Schizosaccharomyces japonicus
APC2 (YLR127C) Saccharomyces cerevisiae

References / Literature

PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.: Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.: Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:25375137 - Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.: Hasan A et al. PLoS Genet 2014 Nov;10(11):e1004684
PMID:18082611 - Structural organization of the anaphase-promoting complex bound to the mitotic activator Slp1.: Ohi MD et al. Mol Cell 2007 Dec 14;28(5):871-85
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.: Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PMID:18556659 - The spindle checkpoint functions of Mad3 and Mad2 depend on a Mad3 KEN box-mediated interaction with Cdc20-anaphase-promoting complex (APC/C).: Sczaniecka M et al. J Biol Chem 2008 Aug 22;283(34):23039-47
PMID:16950791 - Role of Hcn1 and its phosphorylation in fission yeast anaphase-promoting complex/cyclosome function.: Yoon HJ et al. J Biol Chem 2006 Oct 27;281(43):32284-93
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.: Hayles J et al. Open Biol 2013 May 22;3(5):130053
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.: Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.: Mata J et al. Nat Genet 2002 Sep;32(1):143-7
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).: Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:12477395 - Proteomics analysis identifies new components of the fission and budding yeast anaphase-promoting complexes.: Yoon HJ et al. Curr Biol 2002 Dec 10;12(23):2048-54
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.: Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.: Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101
PMID:18354085 - Diminishing HDACs by drugs or mutations promotes normal or abnormal sister chromatid separation by affecting APC/C and adherin.: Kimata Y et al. J Cell Sci 2008 Apr 01;121(Pt 7):1107-18
PMID:15060174 - Swm1/Apc13 is an evolutionarily conserved subunit of the anaphase-promoting complex stabilizing the association of Cdc16 and Cdc27.: Schwickart M et al. Mol Cell Biol 2004 Apr;24(8):3562-76
PMID:21511999 - Comparative functional genomics of the fission yeasts.: Rhind N et al. Science 2011 May 20;332(6032):930-6