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protein coding gene - psf1 (SPBP23A10.09) - GINS complex subunit Psf1

Gene summary

Standard name
psf1
Systematic ID
SPBP23A10.09
Product
GINS complex subunit Psf1
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q9P7X6
ORFeome ID
06/06G12
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 2015362..2016296 forward strand

Annotation

Disease association

MONDO:0044725 - combined immunodeficiency due to GINS1 deficiency

References:

GO biological process

GO:1902983 - DNA strand elongation involved in mitotic DNA replication

References:

GO:1902975 - mitotic DNA replication initiation

References:

GO cellular component

GO:0005829 - cytosol

References:

GO:0000811 - GINS complex

References:

GO:0043596 - nuclear replication fork

References:

GO:0005634 - nucleus

References:

Qualitative gene expression

PomGeneEx:0000011 - RNA level increased

References:

Quantitative gene expression

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0000059 - abnormal mitotic cell cycle

References:

Genotypes:

FYPO:0001343 - abnormal mitotic DNA replication

References:

Genotypes:

FYPO:0001093 - abolished chromatin binding

References:

Genotypes:

FYPO:0001095 - abolished DNA replication origin binding

References:

Genotypes:

FYPO:0001490 - inviable elongated vegetative cell

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0001511 - inviable vegetative cell, abnormal cell shape, normal cell size

References:

Genotypes:

FYPO:0000012 - mitotic G2/M phase transition delay

References:

Genotypes:

FYPO:0001094 - normal DNA replication origin binding

References:

Genotypes:

FYPO:0001492 - viable elongated vegetative cell

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF05916Sld5GINS_APFAM
PF24997PSF1_CPSF1_CPFAM
cd11710GINS_A_psf1GINS_Psf1CDD
cd21696GINS_B_Psf1PSF1_CCDD
SSF158573GINS helical bundle-likeGINS_bundle-like_dom_sfSUPERFAMILY
G3DSA:1.20.58.1030GENE3D
PTHR12914PARTNER OF SLD5GINS_Psf1PANTHER

Orthologs

References / Literature

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:31474649 - Identification of 15 New Bypassable Essential Genes of Fission Yeast.
Takeda A et al. Cell Struct Funct 2019 Sep 27;44(2):113-119
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:22718908 - DNA polymerization-independent functions of DNA polymerase epsilon in assembly and progression of the replisome in fission yeast.
Handa T et al. Mol Biol Cell 2012 Aug;23(16):3240-53
PMID:16990792 - Ordered assembly of Sld3, GINS and Cdc45 is distinctly regulated by DDK and CDK for activation of replication origins.
Yabuuchi H et al. EMBO J 2006 Oct 04;25(19):4663-74
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:30355493 - Expanded Interactome of the Intrinsically Disordered Protein Dss1.
Schenstrøm SM et al. Cell Rep 2018 Oct 23;25(4):862-870
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:39094570 - A replisome-associated histone H3-H4 chaperone required for epigenetic inheritance.
Yu J et al. Cell 2024 Sep 05;187(18):5010-5028.e24
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:19109429 - GINS inactivation phenotypes reveal two pathways for chromatin association of replicative alpha and epsilon DNA polymerases in fission yeast.
Pai CC et al. Mol Biol Cell 2009 Feb;20(4):1213-22
PMID:19228417 - MCM-GINS and MCM-MCM interactions in vivo visualised by bimolecular fluorescence complementation in fission yeast.
Akman G et al. BMC Cell Biol 2009 Feb 19;10:12
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:22433840 - Mcm10 plays an essential role in origin DNA unwinding after loading of the CMG components.
Kanke M et al. EMBO J 2012 May 02;31(9):2182-94