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protein coding gene - sgo1 (SPBP35G2.03c) - meiotic cohesin protection protein, shugoshin, Sgo1

Gene summary

Standard name
sgo1
Systematic ID
SPBP35G2.03c
Product
meiotic cohesin protection protein, shugoshin, Sgo1
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q9P7A0
ORFeome ID
15/15C08
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 967736..968767 reverse strand

Annotation

Disease association

MONDO:0014528 - chronic atrial and intestinal dysrhythmia

References:

GO biological process

GO:0045143 - homologous chromosome segregation

References:

GO:1990813 - meiotic centromeric cohesion protection in anaphase I

References:

GO:0045144 - meiotic sister chromatid segregation

References:

GO:1990758 - mitotic sister chromatid biorientation

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GO:0051455 - spindle attachment to meiosis I kinetochore

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GO cellular component

GO:0000775 - chromosome, centromeric region

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GO:0000779 - condensed chromosome, centromeric region

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GO:0000939 - inner kinetochore

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GO:0000776 - kinetochore

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GO:0072687 - meiotic spindle

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GO:0005635 - nuclear envelope

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GO:0005634 - nucleus

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GO:0005721 - pericentric heterochromatin

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GO molecular function

GO:0140463 - chromatin-protein adaptor activity

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GO:0005515 - protein binding

References:

Multi-locus phenotype

FYPO:0005641 - abnormal chromosome segregation during meiosis I with premature sister kinetochore separation, lagging chromosomes, and normal chromosome separation

References:

Genotypes:

FYPO:0003378 - abolished meiosis I

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Genotypes:

FYPO:0003379 - abolished meiosis II

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Genotypes:

FYPO:0000583 - abolished sporulation

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Genotypes:

FYPO:0000581 - decreased spore germination frequency

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Genotypes:

FYPO:0008202 - equational sister chromatid separation at meiosis I

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

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Genotypes:

FYPO:0002219 - normal chromosome disjunction at meiosis I

References:

Genotypes:

FYPO:0003178 - normal meiotic sister chromatid segregation

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Genotypes:

FYPO:0007853 - normal protein localization to centromere

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Genotypes:

FYPO:0003182 - sister chromatid nondisjunction at meiosis II

References:

Genotypes:

FYPO:0005634 - sister kinetochore dissociation in meiotic metaphase I with equational sister chromatid segregation in meiosis I

References:

Genotypes:

FYPO:0005633 - sister kinetochore dissociation in meiotic metaphase I, normal chromosome segregation in meiosis I, and sister chromatid non-disjunction in meiosis II

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Genotypes:

FYPO:0000678 - unequal homologous chromosome segregation

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

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PomGeneEx:0000018 - protein level increased

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PomGeneEx:0000021 - protein present

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Quantitative gene expression

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0000151 - abnormal meiotic chromosome segregation

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Genotypes:

FYPO:0005509 - abnormal meiotic sister chromatid segregation

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Genotypes:

FYPO:0001893 - abnormal sporulation resulting in formation of azygotic ascus with more or fewer than four spores

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Genotypes:

FYPO:0001093 - abolished chromatin binding

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Genotypes:

FYPO:0006424 - abolished meiotic sister chromatid cohesion at centromere during meiosis I

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Genotypes:

FYPO:0006530 - abolished protein localization to centromere during meiotic prophase II

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Genotypes:

FYPO:0006455 - abolished protein localization to meiotic spindle during meiosis I

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Genotypes:

FYPO:0006456 - abolished protein localization to meiotic spindle during meiosis II

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Genotypes:

FYPO:0007649 - abolished protein localization to pericentric heterochromatin during meiosis II

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Genotypes:

FYPO:0007650 - abolished protein localization to pericentric heterochromatin during meiotic prophase I

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Genotypes:

FYPO:0000705 - abolished protein-protein interaction

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Genotypes:

FYPO:0000583 - abolished sporulation

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Genotypes:

FYPO:0000470 - decreased mating type switching

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Genotypes:

FYPO:0006423 - decreased meiotic sister chromatid cohesion at centromere during meiosis I

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Genotypes:

FYPO:0000460 - decreased mitotic centromeric sister chromatid cohesion

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Genotypes:

FYPO:0004212 - decreased protein localization to kinetochore during meiosis I

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Genotypes:

FYPO:0007993 - decreased protein localization to pericentromeric region during meiosis I

References:

Genotypes:

FYPO:0000581 - decreased spore germination frequency

References:

Genotypes:

FYPO:0002019 - elongated telomeres during vegetative growth

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Genotypes:

FYPO:0002151 - inviable spore

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Genotypes:

FYPO:0004394 - lagging chromosomes during meiosis II

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Genotypes:

FYPO:0006518 - loss of viability in G0

References:

Genotypes:

FYPO:0002219 - normal chromosome disjunction at meiosis I

References:

Genotypes:

FYPO:0007553 - normal G1 to G0 transition

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Genotypes:

FYPO:0002094 - normal meiotic sister chromatid cohesion

References:

Genotypes:

FYPO:0006425 - normal meiotic sister chromatid cohesion at centromere during meiosis I

References:

Genotypes:

FYPO:0007994 - normal meiotic sister chromatid cohesion protection during meiotic anaphase I

References:

Genotypes:

FYPO:0008078 - normal meiotic sister kinetochore association in meiotic metaphase I

References:

Genotypes:

FYPO:0000703 - normal protein-protein interaction

References:

Genotypes:

FYPO:0001357 - normal vegetative cell population growth

References:

Genotypes:

FYPO:0009085 - resistance to lithium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0009087 - resistance to magnesium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0009043 - resistance to potassium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0003383 - resistance to tert-butyl hydroperoxide

References:

Genotypes:

FYPO:0007921 - sensitive to benzamidine

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Genotypes:

FYPO:0000095 - sensitive to bleomycin

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Genotypes:

FYPO:0000088 - sensitive to hydroxyurea

References:

Genotypes:

FYPO:0000089 - sensitive to methyl methanesulfonate

References:

Genotypes:

FYPO:0003656 - sensitive to vanadate

References:

Genotypes:

FYPO:0003182 - sister chromatid nondisjunction at meiosis II

References:

Genotypes:

FYPO:0005648 - sister kinetochore dissociation in meiotic metaphase I

References:

Genotypes:

FYPO:0005634 - sister kinetochore dissociation in meiotic metaphase I with equational sister chromatid segregation in meiosis I

References:

Genotypes:

FYPO:0005633 - sister kinetochore dissociation in meiotic metaphase I, normal chromosome segregation in meiosis I, and sister chromatid non-disjunction in meiosis II

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF07558Shugoshin_NShugoshin_NPFAM
PF07557Shugoshin_CShugoshin_CPFAM
CoilCoilCOILS

Orthologs

References / Literature

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:29196561 - Hierarchical Regulation of Centromeric Cohesion Protection by Meikin and Shugoshin during Meiosis I.
Miyazaki S et al. Cold Spring Harb Symp Quant Biol 2017;82:259-266
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:21920317 - Repositioning of aurora B promoted by chiasmata ensures sister chromatid mono-orientation in meiosis I.
Sakuno T et al. Dev Cell 2011 Sep 13;21(3):534-45
PMID:22540037 - Predicting the fission yeast protein interaction network.
Pancaldi V et al. G3 (Bethesda) 2012 Apr;2(4):453-67
PMID:16541025 - Shugoshin collaborates with protein phosphatase 2A to protect cohesin.
Kitajima TS et al. Nature 2006 May 04;441(7089):46-52
PMID:26483559 - Nup132 modulates meiotic spindle attachment in fission yeast by regulating kinetochore assembly.
Yang HJ et al. J Cell Biol 2015 Oct 26;211(2):295-308
PMID:19965387 - Phosphorylation of H2A by Bub1 prevents chromosomal instability through localizing shugoshin.
Kawashima SA et al. Science 2010 Jan 08;327(5962):172-7
PMID:14730319 - The conserved kinetochore protein shugoshin protects centromeric cohesion during meiosis.
Kitajima TS et al. Nature 2004 Feb 05;427(6974):510-7
PMID:14972679 - Two fission yeast homologs of Drosophila Mei-S332 are required for chromosome segregation during meiosis I and II.
Rabitsch KP et al. Curr Biol 2004 Feb 17;14(4):287-301
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:16303567 - A large-scale screen in S. pombe identifies seven novel genes required for critical meiotic events.
Martín-Castellanos C et al. Curr Biol 2005 Nov 22;15(22):2056-62
PMID:16169489 - Novel genes required for meiotic chromosome segregation are identified by a high-throughput knockout screen in fission yeast.
Gregan J et al. Curr Biol 2005 Sep 20;15(18):1663-9
PMID:20739936 - Phosphorylation of the CPC by Cdk1 promotes chromosome bi-orientation.
Tsukahara T et al. Nature 2010 Oct 07;467(7316):719-23
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:23173672 - Identification of novel genes involved in DNA damage response by screening a genome-wide Schizosaccharomyces pombe deletion library.
Pan X et al. BMC Genomics 2012 Nov 23;13:662
PMID:28497540 - Meikin-associated polo-like kinase specifies Bub1 distribution in meiosis I.
Miyazaki S et al. Genes Cells 2017 Jun;22(6):552-567
PMID:33529549 - Chiasmata and the kinetochore component Dam1 are crucial for elimination of erroneous chromosome attachments and centromere oscillation at meiosis I.
Wakiya M et al. Open Biol 2021 Feb;11(2):200308
PMID:33260998 - High-Throughput Flow Cytometry Combined with Genetic Analysis Brings New Insights into the Understanding of Chromatin Regulation of Cellular Quiescence.
Zahedi Y et al. Int J Mol Sci 2020 Nov 27;21(23)
PMID:34851403 - Direct evaluation of cohesin-mediated sister kinetochore associations at meiosis I in fission yeast.
Nambu M et al. J Cell Sci 2022 Jan 01;135(1)
PMID:17035632 - Reconstruction of the kinetochore during meiosis in fission yeast Schizosaccharomyces pombe.
Hayashi A et al. Mol Biol Cell 2006 Dec;17(12):5173-84
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:21423721 - Chiasmata promote monopolar attachment of sister chromatids and their co-segregation toward the proper pole during meiosis I.
Hirose Y et al. PLoS Genet 2011 Mar;7(3):e1001329
PMID:16541024 - Protein phosphatase 2A protects centromeric sister chromatid cohesion during meiosis I.
Riedel CG et al. Nature 2006 May 04;441(7089):53-61
PMID:29769606 - Malonylation of histone H2A at lysine 119 inhibits Bub1-dependent H2A phosphorylation and chromosomal localization of shugoshin proteins.
Ishiguro T et al. Sci Rep 2018 May 16;8(1):7671
PMID:18716626 - Heterochromatin links to centromeric protection by recruiting shugoshin.
Yamagishi Y et al. Nature 2008 Sep 11;455(7210):251-5
PMID:28942089 - Biochemical Basis for Distinct Roles of the Heterochromatin Proteins Swi6 and Chp2.
Isaac RS et al. J Mol Biol 2017 Nov 24;429(23):3666-3677
PMID:29852001 - New insights into donor directionality of mating-type switching in Schizosaccharomyces pombe.
Maki T et al. PLoS Genet 2018 May;14(5):e1007424
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:20383139 - Shugoshin-PP2A counteracts casein-kinase-1-dependent cleavage of Rec8 by separase.
Ishiguro T et al. Nat Cell Biol 2010 May;12(5):500-6
PMID:16325576 - The kinetochore protein Moa1 enables cohesion-mediated monopolar attachment at meiosis I.
Yokobayashi S et al. Cell 2005 Dec 02;123(5):803-17
PMID:20625380 - A genome-wide screen for Schizosaccharomyces pombe deletion mutants that affect telomere length.
Liu NN et al. Cell Res 2010 Aug;20(8):963-5
PMID:16360688 - Control of Shugoshin function during fission-yeast meiosis.
Vaur S et al. Curr Biol 2005 Dec 20;15(24):2263-70
PMID:29259000 - Genes Important for Schizosaccharomyces pombe Meiosis Identified Through a Functional Genomics Screen.
Blyth J et al. Genetics 2018 Feb;208(2):589-603
PMID:32790622 - Atypical meiosis can be adaptive in outcrossed Schizosaccharomyces pombe due to wtf meiotic drivers.
Bravo Núñez MA et al. Elife 2020 Aug 13;9
PMID:27611693 - A Taz1- and Microtubule-Dependent Regulatory Relationship between Telomere and Centromere Positions in Bouquet Formation Secures Proper Meiotic Divisions.
Katsumata K et al. PLoS Genet 2016 Sep;12(9):e1006304
PMID:25579976 - Phosphorylation of cohesin Rec11/SA3 by casein kinase 1 promotes homologous recombination by assembling the meiotic chromosome axis.
Sakuno T et al. Dev Cell 2015 Jan 26;32(2):220-30
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:33888556 - Meikin synergizes with shugoshin to protect cohesin Rec8 during meiosis I.
Ma W et al. Genes Dev 2021 May 01;35(9-10):692-697