protein coding gene - sgo1 (SPBP35G2.03c) - meiotic cohesin protection protein, shugoshin, Sgo1

Gene summary

Standard name

sgo1

Systematic ID

SPBP35G2.03c

Product

meiotic cohesin protection protein, shugoshin, Sgo1

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

Q9P7A0

ORFeome ID

15/15C08

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome II: 967736..968767 reverse strand

Annotation

Protein features

Orthologs

• SGO1 (HGNC:25088) Homo sapiens
• sgo1 (SJAG_03989) Schizosaccharomyces japonicus
• SGO1 (YOR073W) Saccharomyces cerevisiae

References / Literature

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:25579976 - Phosphorylation of cohesin Rec11/SA3 by casein kinase 1 promotes homologous recombination by assembling the meiotic chromosome axis.

Sakuno T et al. Dev Cell 2015 Jan 26;32(2):220-30

PMID:14730319 - The conserved kinetochore protein shugoshin protects centromeric cohesion during meiosis.

Kitajima TS et al. Nature 2004 Feb 05;427(6974):510-7

PMID:16541025 - Shugoshin collaborates with protein phosphatase 2A to protect cohesin.

Kitajima TS et al. Nature 2006 May 04;441(7089):46-52

PMID:19965387 - Phosphorylation of H2A by Bub1 prevents chromosomal instability through localizing shugoshin.

Kawashima SA et al. Science 2010 Jan 08;327(5962):172-7

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:20739936 - Phosphorylation of the CPC by Cdk1 promotes chromosome bi-orientation.

Tsukahara T et al. Nature 2010 Oct 07;467(7316):719-23

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:16169489 - Novel genes required for meiotic chromosome segregation are identified by a high-throughput knockout screen in fission yeast.

Gregan J et al. Curr Biol 2005 Sep 20;15(18):1663-9

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704

PMID:28497540 - Meikin-associated polo-like kinase specifies Bub1 distribution in meiosis I.

Miyazaki S et al. Genes Cells 2017 Jun;22(6):552-567

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:27611693 - A Taz1- and Microtubule-Dependent Regulatory Relationship between Telomere and Centromere Positions in Bouquet Formation Secures Proper Meiotic Divisions.

Katsumata K et al. PLoS Genet 2016 Sep;12(9):e1006304

PMID:41786187 - Shugoshin holds the potential to inhibit APC/C and thereby prevents separase activation.

Zhang K et al. Int J Biol Macromol 2026 Mar 03;:151175

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:26483559 - Nup132 modulates meiotic spindle attachment in fission yeast by regulating kinetochore assembly.

Yang HJ et al. J Cell Biol 2015 Oct 26;211(2):295-308

PMID:20118936 - Schizosaccharomyces pombe genome-wide nucleosome mapping reveals positioning mechanisms distinct from those of Saccharomyces cerevisiae.

Lantermann AB et al. Nat Struct Mol Biol 2010 Feb;17(2):251-7

PMID:18716626 - Heterochromatin links to centromeric protection by recruiting shugoshin.

Yamagishi Y et al. Nature 2008 Sep 11;455(7210):251-5

PMID:20383139 - Shugoshin-PP2A counteracts casein-kinase-1-dependent cleavage of Rec8 by separase.

Ishiguro T et al. Nat Cell Biol 2010 May;12(5):500-6

PMID:16541024 - Protein phosphatase 2A protects centromeric sister chromatid cohesion during meiosis I.

Riedel CG et al. Nature 2006 May 04;441(7089):53-61

PMID:16360688 - Control of Shugoshin function during fission-yeast meiosis.

Vaur S et al. Curr Biol 2005 Dec 20;15(24):2263-70

PMID:22540037 - Predicting the fission yeast protein interaction network.

Pancaldi V et al. G3 (Bethesda) 2012 Apr;2(4):453-67

PMID:28942089 - Biochemical Basis for Distinct Roles of the Heterochromatin Proteins Swi6 and Chp2.

Isaac RS et al. J Mol Biol 2017 Nov 24;429(23):3666-3677

PMID:21423721 - Chiasmata promote monopolar attachment of sister chromatids and their co-segregation toward the proper pole during meiosis I.

Hirose Y et al. PLoS Genet 2011 Mar;7(3):e1001329

PMID:23173672 - Identification of novel genes involved in DNA damage response by screening a genome-wide Schizosaccharomyces pombe deletion library.

Pan X et al. BMC Genomics 2012 Nov 23;13:662

PMID:21920317 - Repositioning of aurora B promoted by chiasmata ensures sister chromatid mono-orientation in meiosis I.

Sakuno T et al. Dev Cell 2011 Sep 13;21(3):534-45

PMID:14972679 - Two fission yeast homologs of Drosophila Mei-S332 are required for chromosome segregation during meiosis I and II.

Rabitsch KP et al. Curr Biol 2004 Feb 17;14(4):287-301

PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.

Mata J et al. Nat Genet 2002 Sep;32(1):143-7

PMID:16325576 - The kinetochore protein Moa1 enables cohesion-mediated monopolar attachment at meiosis I.

Yokobayashi S et al. Cell 2005 Dec 02;123(5):803-17

PMID:29259000 - Genes Important for Schizosaccharomyces pombe Meiosis Identified Through a Functional Genomics Screen.

Blyth J et al. Genetics 2018 Feb;208(2):589-603

PMID:16303567 - A large-scale screen in S. pombe identifies seven novel genes required for critical meiotic events.

Martín-Castellanos C et al. Curr Biol 2005 Nov 22;15(22):2056-62

PMID:29196561 - Hierarchical Regulation of Centromeric Cohesion Protection by Meikin and Shugoshin during Meiosis I.

Miyazaki S et al. Cold Spring Harb Symp Quant Biol 2017;82:259-266

PMID:29769606 - Malonylation of histone H2A at lysine 119 inhibits Bub1-dependent H2A phosphorylation and chromosomal localization of shugoshin proteins.

Ishiguro T et al. Sci Rep 2018 May 16;8(1):7671

PMID:32790622 - Atypical meiosis can be adaptive in outcrossed Schizosaccharomyces pombe due to wtf meiotic drivers.

Bravo Núñez MA et al. Elife 2020 Aug 13;9

PMID:17035632 - Reconstruction of the kinetochore during meiosis in fission yeast Schizosaccharomyces pombe.

Hayashi A et al. Mol Biol Cell 2006 Dec;17(12):5173-84

PMID:20625380 - A genome-wide screen for Schizosaccharomyces pombe deletion mutants that affect telomere length.

Liu NN et al. Cell Res 2010 Aug;20(8):963-5

PMID:29852001 - New insights into donor directionality of mating-type switching in Schizosaccharomyces pombe.

Maki T et al. PLoS Genet 2018 May;14(5):e1007424

PMID:33260998 - High-Throughput Flow Cytometry Combined with Genetic Analysis Brings New Insights into the Understanding of Chromatin Regulation of Cellular Quiescence.

Zahedi Y et al. Int J Mol Sci 2020 Nov 27;21(23)

GO_REF:0000108 - Automatic assignment of GO terms using logical inference, based on on inter-ontology links.

PMID:33529549 - Chiasmata and the kinetochore component Dam1 are crucial for elimination of erroneous chromosome attachments and centromere oscillation at meiosis I.

Wakiya M et al. Open Biol 2021 Feb;11(2):200308

PMID:33888556 - Meikin synergizes with shugoshin to protect cohesin Rec8 during meiosis I.

Ma W et al. Genes Dev 2021 May 01;35(9-10):692-697

PMID:34851403 - Direct evaluation of cohesin-mediated sister kinetochore associations at meiosis I in fission yeast.

Nambu M et al. J Cell Sci 2022 Jan 01;135(1)

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12