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protein coding gene - nup131 (SPBP35G2.06c) - nucleoporin, WD repeat Nup131

Gene summary

Standard name
nup131
Systematic ID
SPBP35G2.06c
Product
nucleoporin, WD repeat Nup131
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
Nup133a
UniProt ID
Q9P797
ORFeome ID
48/48D11
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 973022..976846 reverse strand

Annotation

Disease association

MONDO:0032693 - Galloway-Mowat syndrome 8

References:

MONDO:0032581 - nephrotic syndrome, type 18

References:

GO biological process

GO:0016973 - poly(A)+ mRNA export from nucleus

References:

GO:0006606 - protein import into nucleus

References:

GO:0000972 - transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery

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GO cellular component

GO:0032153 - cell division site

References:

GO:0005737 - cytoplasm

References:

GO:0005829 - cytosol

References:

GO:0005635 - nuclear envelope

References:

GO:0005643 - nuclear pore

References:

GO:0031080 - nuclear pore outer ring

References:

GO molecular function

GO:0005515 - protein binding

References:

GO:0017056 - structural constituent of nuclear pore

References:

Multi-locus phenotype

FYPO:0007532 - decreased replication fork colocalization with nuclear pore complex

References:

Genotypes:

FYPO:0003589 - decreased replication slippage during replication fork processing

References:

Genotypes:

FYPO:0004003 - delayed onset of replication fork processing

References:

Genotypes:

FYPO:0000614 - increased duration of mitotic S phase

References:

Genotypes:

FYPO:0000969 - normal growth during cellular response to UV

References:

Genotypes:

FYPO:0003906 - normal growth on bleomycin

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Genotypes:

Protein features

PBO:0111751 - WD repeat protein

Qualitative gene expression

PomGeneEx:0000011 - RNA level increased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0000121 - abnormal sporulation

References:

Genotypes:

FYPO:0000581 - decreased spore germination frequency

References:

Genotypes:

FYPO:0004806 - incomplete cell wall disassembly at cell fusion site

References:

Genotypes:

FYPO:0000969 - normal growth during cellular response to UV

References:

Genotypes:

FYPO:0003906 - normal growth on bleomycin

References:

Genotypes:

FYPO:0001690 - normal growth on camptothecin

References:

Genotypes:

FYPO:0000963 - normal growth on hydroxyurea

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Genotypes:

FYPO:0000957 - normal growth on methyl methanesulfonate

References:

Genotypes:

FYPO:0007533 - normal replication fork colocalization with nuclear pore complex

References:

Genotypes:

FYPO:0001317 - normal RNA level during vegetative growth

References:

Genotypes:

FYPO:0000764 - resistance to cycloheximide

References:

Genotypes:

FYPO:0009038 - resistance to egtazic acid

References:

Genotypes:

FYPO:0009085 - resistance to lithium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0009087 - resistance to magnesium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0009043 - resistance to potassium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0001097 - sensitive to amitrole

References:

Genotypes:

FYPO:0006680 - sensitive to bisphenol A

References:

Genotypes:

FYPO:0000797 - sensitive to tert-butyl hydroperoxide

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Warnings

PBO:0000070 - gene structure updated

References:

Protein features

IDNameInterPro nameDB name
PF08801Nucleoporin_NNucleoporin_Nup133/Nup155_NPFAM
SSF117289Nucleoporin domainSUPERFAMILY
G3DSA:1.20.58.1380GENE3D
G3DSA:2.130.10.10WD40/YVTN_repeat-like_dom_sfGENE3D
PTHR13405NUCLEAR PORE COMPLEX PROTEIN NUP133Nup133-likePANTHER

Orthologs

References / Literature

PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:23658229 - Red5 and three nuclear pore components are essential for efficient suppression of specific mRNAs during vegetative growth of fission yeast.
Sugiyama T et al. Nucleic Acids Res 2013 Jul;41(13):6674-86
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:30647105 - Comparative Genomic Screen in Two Yeasts Reveals Conserved Pathways in the Response Network to Phenol Stress.
Alhoch B et al. G3 (Bethesda) 2019 Mar 07;9(3):639-650
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:20970342 - Virtual breakdown of the nuclear envelope in fission yeast meiosis.
Asakawa H et al. Curr Biol 2010 Nov 09;20(21):1919-25
PMID:33159083 - The nuclear pore primes recombination-dependent DNA synthesis at arrested forks by promoting SUMO removal.
Kramarz K et al. Nat Commun 2020 Nov 06;11(1):5643
PMID:18818364 - Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast.
Roguev A et al. Science 2008 Oct 17;322(5900):405-10
PMID:28410370 - A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.
Dudin O et al. PLoS Genet 2017 Apr;13(4):e1006721
PMID:29432178 - General amino acid control in fission yeast is regulated by a nonconserved transcription factor, with functions analogous to Gcn4/Atf4.
Duncan CDS et al. Proc Natl Acad Sci U S A 2018 Feb 20;115(8):E1829-E1838
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:33176152 - Acute Heat Stress Leads to Reversible Aggregation of Nuclear Proteins into Nucleolar Rings in Fission Yeast.
Gallardo P et al. Cell Rep 2020 Nov 10;33(6):108377
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:24637836 - Characterization of nuclear pore complex components in fission yeast Schizosaccharomyces pombe.
Asakawa H et al. Nucleus 2014;5(2):149-62
PMID:15226438 - The fission yeast Nup107-120 complex functionally interacts with the small GTPase Ran/Spi1 and is required for mRNA export, nuclear pore distribution, and proper cell division.
Baï SW et al. Mol Cell Biol 2004 Jul;24(14):6379-92