protein coding gene - ecl2 (SPBP35G2.16c) - TORC1 inhibitor, Ecl2

Gene summary

Standard name

ecl2

Systematic ID

SPBP35G2.16c

Product

TORC1 inhibitor, Ecl2

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

SPNGAF61

UniProt ID

C6Y4C5

Characterisation status

biological role inferred

Feature type

mRNA gene

Genomic location

chromosome II: 961007..962515 reverse strand

Annotation

Protein features

Orthologs

• ecl1 (SJAG_03974) Schizosaccharomyces japonicus
• ECL1 (YGR146C) Saccharomyces cerevisiae

References / Literature

PMID:28388826 - Sulfur restriction extends fission yeast chronological lifespan through Ecl1 family genes by downregulation of ribosome.

Ohtsuka H et al. Mol Microbiol 2017 Jul;105(1):84-97

PMID:28160081 - Ecl1 is a zinc-binding protein involved in the zinc-limitation-dependent extension of chronological life span in fission yeast.

Shimasaki T et al. Mol Genet Genomics 2017 Apr;292(2):475-481

PMID:31456006 - Leucine depletion extends the lifespans of leucine-auxotrophic fission yeast by inducing Ecl1 family genes via the transcription factor Fil1.

Ohtsuka H et al. Mol Genet Genomics 2019 Dec;294(6):1499-1509

PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.

Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399

PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

Halova L et al. Open Biol 2021 Apr;11(4):200405

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.

Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87

PMID:26896847 - Ensembl comparative genomics resources.

Herrero J et al. Database (Oxford) 2016;2016

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:21072667 - hsf1 (+) extends chronological lifespan through Ecl1 family genes in fission yeast.

Ohtsuka H et al. Mol Genet Genomics 2011 Jan;285(1):67-77

PMID:33970532 - Magnesium depletion extends fission yeast lifespan via general amino acid control activation.

Ohtsuka H et al. Microbiologyopen 2021 Mar;10(2):e1176

PMID:22212525 - Chronological lifespan extension by Ecl1 family proteins depends on Prr1 response regulator in fission yeast.

Ohtsuka H et al. Genes Cells 2012 Jan;17(1):39-52

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:39910760 - Novel TORC1 inhibitor Ecl1 is regulated by phosphorylation in fission yeast.

Ohtsuka H et al. Aging Cell 2025 Feb 05;:e14450

PMID:40395999 - Cdc13 (cyclin B) is degraded by autophagy under sulfur depletion in fission yeast.

Ohtsuka H et al. Autophagy Rep 2022;1(1):51-64

GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.

PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.

Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514

PMID:27168121 - Discovery of genes involved in mitosis, cell division, cell wall integrity and chromosome segregation through construction of Schizosaccharomyces pombe deletion strains.

Chen JS et al. Yeast 2016 Sep;33(9):507-17

PMID:24696293 - Ecl1 is activated by the transcription factor Atf1 in response to H2O2 stress in Schizosaccharomyces pombe.

Shimasaki T et al. Mol Genet Genomics 2014 Aug;289(4):685-93

PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.

Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101

PMID:19352039 - Identification of Ecl family genes that extend chronological lifespan in fission yeast.

Ohtsuka H et al. Biosci Biotechnol Biochem 2009 Apr 23;73(4):885-9

PMID:25204792 - Sexual development of Schizosaccharomyces pombe is induced by zinc or iron limitation through Ecl1 family genes.

Ohtsuka H et al. Mol Genet Genomics 2015 Feb;290(1):173-85

PMID:29432178 - General amino acid control in fission yeast is regulated by a nonconserved transcription factor, with functions analogous to Gcn4/Atf4.

Duncan CDS et al. Proc Natl Acad Sci U S A 2018 Feb 20;115(8):E1829-E1838

PMID:39105351 - A novel transcription factor Sdr1 involving sulfur depletion response in fission yeast.

Ohtsuka H et al. Genes Cells 2024 Aug;29(8):667-680

PMID:36779416 - The ecl family gene ecl3+ is induced by phosphate starvation and contributes to sexual differentiation in fission yeast.

Ohtsuka H et al. J Cell Sci 2023 Mar 15;136(6)

PMID:33064910 - Sulfur depletion induces autophagy through Ecl1 family genes in fission yeast.

Shimasaki T et al. Genes Cells 2020 Dec;25(12):825-830

PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.

Skribbe M et al. Mol Cell 2025 Feb 19;