protein coding gene - pho1 (SPBP4G3.02) - extracellular acid phosphatase Pho1

Gene summary

Standard name

pho1

Systematic ID

SPBP4G3.02

Product

extracellular acid phosphatase Pho1

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

P08091

ORFeome ID

40/40E01

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome II: 4447506..4449053 forward strand

Annotation

Protein features

Orthologs

• MINPP1 (HGNC:7102) Homo sapiens
• SJAG_01970 Schizosaccharomyces japonicus
• SJAG_04067 Schizosaccharomyces japonicus
• PHO11 (YAR071W) Saccharomyces cerevisiae
• PHO3 (YBR092C) Saccharomyces cerevisiae
• PHO5 (YBR093C) Saccharomyces cerevisiae
• DIA3 (YDL024C) Saccharomyces cerevisiae
• PHO12 (YHR215W) Saccharomyces cerevisiae

References / Literature

PMID:21169418 - Systematic screen of Schizosaccharomyces pombe deletion collection uncovers parallel evolution of the phosphate signal transduction pathway in yeasts.

Henry TC et al. Eukaryot Cell 2011 Feb;10(2):198-206

PMID:3005272 - Isolation and characterization of the structural gene for secreted acid phosphatase from Schizosaccharomyces pombe.

Elliott S et al. J Biol Chem 1986 Feb 25;261(6):2936-41

PMID:31010807 - Structure of Fission Yeast Transcription Factor Pho7 Bound to pho1 Promoter DNA and Effect of Pho7 Mutations on DNA Binding and Phosphate Homeostasis.

Garg A et al. Mol Cell Biol 2019 Jul 01;39(13)

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:33579781 - Transcriptional profiling of fission yeast RNA polymerase II CTD mutants.

Garg A et al. RNA 2021 Feb 12;27(5):560-70

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:38899862 - Suppression of inositol pyrophosphate toxicosis and hyper-repression of the fission yeast PHO regulon by loss-of-function mutations in chromatin remodelers Snf22 and Sol1.

Schwer B et al. mBio 2024 Jun 20;:e0125224

PMID:12845604 - Genome-wide identification of fungal GPI proteins.

De Groot PW et al. Yeast 2003 Jul 15;20(9):781-96

PMID:33010152 - A genetic screen for suppressors of hyper-repression of the fission yeast PHO regulon by Pol2 CTD mutation T4A implicates inositol 1-pyrophosphates as agonists of precocious lncRNA transcription termination.

Garg A et al. Nucleic Acids Res 2020 Nov 04;48(19):10739-10752

PMID:1318242 - Synthesis and degradation of polyphosphate in the fission yeast Schizosaccharomyces pombe: mutations in phosphatase genes do not affect polyphosphate metabolism.

Müller J et al. FEMS Microbiol Lett 1992 Apr 15;71(2):151-6

PMID:38940614 - Activities and genetic interactions of fission yeast Aps1, a Nudix-type inositol pyrophosphatase and inorganic polyphosphatase.

Ghosh S et al. mBio 2024 Jun 28;:e0108424

PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.

Skribbe M et al. Mol Cell 2025 Feb 19;

GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.

PMID:32415063 - Conserved protein Pir2 ARS2 mediates gene repression through cryptic introns in lncRNAs.

Thillainadesan G et al. Nat Commun 2020 May 15;11(1):2412

PMID:39105351 - A novel transcription factor Sdr1 involving sulfur depletion response in fission yeast.

Ohtsuka H et al. Genes Cells 2024 Aug;29(8):667-680

PMID:26749213 - The AP-2 complex is required for proper temporal and spatial dynamics of endocytic patches in fission yeast.

de León N et al. Mol Microbiol 2016 May;100(3):409-24

PMID:36478272 - Translation-complex profiling of fission yeast cells reveals dynamic rearrangements of scanning ribosomal subunits upon nutritional stress.

Duncan CDS et al. Nucleic Acids Res 2022 Dec 09;50(22):13011-13025

PMID:40063661 - Fission yeast Caprin protein is required for efficient heterochromatin establishment.

Zhang H et al. PLoS Genet 2025 Mar 10;21(3):e1011620

PMID:4092931 - Cloning and characterization of two genes restoring acid phosphatase activity in pho1- mutants of Schizosaccharomyces pombe.

Maundrell K et al. Gene 1985;39(2-3):223-30

PMID:31626996 - Multiplexed proteome profiling of carbon source perturbations in two yeast species with SL-SP3-TMT.

Paulo JA et al. J Proteomics 2020 Jan 06;210:103531

PMID:36779416 - The ecl family gene ecl3+ is induced by phosphate starvation and contributes to sexual differentiation in fission yeast.

Ohtsuka H et al. J Cell Sci 2023 Mar 15;136(6)

PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.

Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:9839953 - Differences in in vivo acceptor specificity of two galactosyltransferases, the gmh3+ and gma12+ gene products from Schizosaccharomyces pombe.

Yoko-o T et al. Eur J Biochem 1998 Nov 01;257(3):630-7

PMID:2381421 - Effects of seven different mutations in the pho1 gene on enzymatic activity, glycosylation and secretion of acid phosphatase in Schizosaccharomyces pombe.

Schwaninger R et al. Mol Gen Genet 1990 May;221(3):403-10

PMID:29432178 - General amino acid control in fission yeast is regulated by a nonconserved transcription factor, with functions analogous to Gcn4/Atf4.

Duncan CDS et al. Proc Natl Acad Sci U S A 2018 Feb 20;115(8):E1829-E1838

PMID:20118936 - Schizosaccharomyces pombe genome-wide nucleosome mapping reveals positioning mechanisms distinct from those of Saccharomyces cerevisiae.

Lantermann AB et al. Nat Struct Mol Biol 2010 Feb;17(2):251-7

PMID:23231582 - Genome-wide characterization of the phosphate starvation response in Schizosaccharomyces pombe.

Carter-O'Connell I et al. BMC Genomics 2012 Dec 12;13:697

PMID:28811350 - Defining the DNA Binding Site Recognized by the Fission Yeast Zn 2 Cys 6 Transcription Factor Pho7 and Its Role in Phosphate Homeostasis.

Schwer B et al. mBio 2017 Aug 15;8(4)

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:26264592 - RNA polymerase II CTD phospho-sites Ser5 and Ser7 govern phosphate homeostasis in fission yeast.

Schwer B et al. RNA 2015 Oct;21(10):1770-80

PMID:28218250 - Chromatin remodeller Fun30 Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Lee J et al. Nat Commun 2017 Feb 20;8:14527

PMID:36794724 - Cellular responses to long-term phosphate starvation of fission yeast: Maf1 determines fate choice between quiescence and death associated with aberrant tRNA biogenesis.

Garg A et al. Nucleic Acids Res 2023 Apr 24;51(7):3094-3115

PMID:33711009 - Structure-function analysis of fission yeast cleavage and polyadenylation factor (CPF) subunit Ppn1 and its interactions with Dis2 and Swd22.

Benjamin B et al. PLoS Genet 2021 Mar;17(3):e1009452

PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

Halova L et al. Open Biol 2021 Apr;11(4):200405

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:25375137 - Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.

Hasan A et al. PLoS Genet 2014 Nov;10(11):e1004684

PMID:20625380 - A genome-wide screen for Schizosaccharomyces pombe deletion mutants that affect telomere length.

Liu NN et al. Cell Res 2010 Aug;20(8):963-5

PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.

Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399

PMID:24192486 - The conserved Fanconi anemia nuclease Fan1 and the SUMO E3 ligase Pli1 act in two novel Pso2-independent pathways of DNA interstrand crosslink repair in yeast.

Fontebasso Y et al. DNA Repair (Amst) 2013 Dec;12(12):1011-23

PMID:39660919 - Efn1 and Efn2 are extracellular 5'-nucleotidases induced during the fission yeast response to phosphate starvation.

Innokentev A et al. mBio 2024 Dec 11;:e0299224

PMID:21899677 - Cdc42 regulates multiple membrane traffic events in fission yeast.

Estravís M et al. Traffic 2011 Dec;12(12):1744-58

PMID:25428589 - Long non-coding RNA-mediated transcriptional interference of a permease gene confers drug tolerance in fission yeast.

Ard R et al. Nat Commun 2014 Nov 27;5:5576

PMID:22633491 - Mapping N-glycosylation sites across seven evolutionarily distant species reveals a divergent substrate proteome despite a common core machinery.

Zielinska DF et al. Mol Cell 2012 May 25;46(4):542-8

PMID:35012333 - Cleavage-Polyadenylation Factor Cft1 and SPX Domain Proteins Are Agents of Inositol Pyrophosphate Toxicosis in Fission Yeast.

Schwer B et al. mBio 2022 Feb 22;13(1):e0347621

PMID:3536917 - Identification and characterization of thiamin repressible acid phosphatase in yeast.

Schweingruber ME et al. J Biol Chem 1986 Dec 05;261(34):15877-82

PMID:19933844 - Fission yeast Iec1-ino80-mediated nucleosome eviction regulates nucleotide and phosphate metabolism.

Hogan CJ et al. Mol Cell Biol 2010 Feb;30(3):657-74

PMID:24493644 - lncRNA recruits RNAi and the exosome to dynamically regulate pho1 expression in response to phosphate levels in fission yeast.

Shah S et al. Genes Dev 2014 Feb 01;28(3):231-44

PMID:41750377 - Transporter-Driven Glycerophosphocholine (GPC) Toxicity Is Conserved from Fission Yeast to Budding Yeast: Roles for Inositol Pyrophosphates and Gde1 Regulation in Fission Yeast.

Hrach VL et al. Biomolecules 2026 Feb 16;16(2)

PMID:32546512 - Inactivation of fission yeast Erh1 de-represses pho1 expression: evidence that Erh1 is a negative regulator of prt lncRNA termination.

Schwer B et al. RNA 2020 Oct;26(10):1334-1344

PMID:25547512 - Dissection of the PHO pathway in Schizosaccharomyces pombe using epistasis and the alternate repressor adenine.

Estill M et al. Curr Genet 2015 May;61(2):175-83

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs

PMID:3447747 - Acid phosphatase deficient mutants of Schizosaccharomyces pombe are defective in tyrosine uptake.

Coddington A et al. Curr Genet 1986;11(2):113-7

PMID:36882296 - Duf89 abets lncRNA control of fission yeast phosphate homeostasis via its antagonism of precocious lncRNA transcription termination.

Sanchez AM et al. RNA 2023 Jun;29(6):808-825

PMID:25483073 - Chromosome segregation and organization are targets of 5'-Fluorouracil in eukaryotic cells.

Mojardín L et al. Cell Cycle 2015;14(2):206-18

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:32499400 - Nutrient-dependent control of RNA polymerase II elongation rate regulates specific gene expression programs by alternative polyadenylation.

Yague-Sanz C et al. Genes Dev 2020 Jul 01;34(13-14):883-897

PMID:3732265 - Glycosylation and secretion of acid phosphatase in Schizosaccharomyces pombe.

Schweingruber AM et al. Eur J Biochem 1986 Jul 01;158(1):133-40

PMID:29414789 - A long noncoding (lnc)RNA governs expression of the phosphate transporter Pho84 in fission yeast and has cascading effects on the flanking prt lncRNA and pho1 genes.

Garg A et al. J Biol Chem 2018 Mar 23;293(12):4456-4467

PMID:34967420 - Genetic screen for suppression of transcriptional interference reveals fission yeast 14-3-3 protein Rad24 as an antagonist of precocious Pol2 transcription termination.

Garg A et al. Nucleic Acids Res 2022 Jan 25;50(2):803-819

PMID:1394510 - Regulation of pho1-encoded acid phosphatase of Schizosaccharomyces pombe by adenine and phosphate.

Schweingruber ME et al. Curr Genet 1992 Oct;22(4):289-92

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704

PMID:35314193 - Fission yeast Duf89 and Duf8901 are cobalt/nickel-dependent phosphatase-pyrophosphatases that act via a covalent aspartyl-phosphate intermediate.

Sanchez AM et al. J Biol Chem 2022 May;298(5):101851

PMID:7499352 - Schizosaccharomyces pombe thiamine pyrophosphokinase is encoded by gene tnr3 and is a regulator of thiamine metabolism, phosphate metabolism, mating, and growth.

Fankhauser H et al. J Biol Chem 1995 Nov 24;270(47):28457-62

PMID:36002457 - Structural analysis of Red1 as a conserved scaffold of the RNA-targeting MTREC/PAXT complex.

Foucher AE et al. Nat Commun 2022 Aug 24;13(1):4969

PMID:24210919 - Mtr4-like protein coordinates nuclear RNA processing for heterochromatin assembly and for telomere maintenance.

Lee NN et al. Cell 2013 Nov 21;155(5):1061-74

PMID:7969124 - The Srp54 GTPase is essential for protein export in the fission yeast Schizosaccharomyces pombe.

Althoff SM et al. Mol Cell Biol 1994 Dec;14(12):7839-54

PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.

UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531

PMID:31276588 - Inositol pyrophosphates impact phosphate homeostasis via modulation of RNA 3' processing and transcription termination.

Sanchez AM et al. Nucleic Acids Res 2019 Sep 19;47(16):8452-8469

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:29618061 - Histone deacetylation promotes transcriptional silencing at facultative heterochromatin.

Watts BR et al. Nucleic Acids Res 2018 Jun 20;46(11):5426-5440

PMID:32282918 - Genetic interactions and transcriptomics implicate fission yeast CTD prolyl isomerase Pin1 as an agent of RNA 3' processing and transcription termination that functions via its effects on CTD phosphatase Ssu72.

Sanchez AM et al. Nucleic Acids Res 2020 May 21;48(9):4811-4826

PMID:26670050 - Regulation of mRNA Levels by Decay-Promoting Introns that Recruit the Exosome Specificity Factor Mmi1.

Kilchert C et al. Cell Rep 2015 Dec 22;13(11):2504-2515

PMID:35536002 - Activities and Structure-Function Analysis of Fission Yeast Inositol Pyrophosphate (IPP) Kinase-Pyrophosphatase Asp1 and Its Impact on Regulation of pho1 Gene Expression.

Benjamin B et al. mBio 2022 Jun 28;13(3):e0103422

PMID:38133430 - Genetic suppressor screen identifies Tgp1 (glycerophosphocholine transporter), Kcs1 (IP 6 kinase), and Plc1 (phospholipase C) as determinants of inositol pyrophosphate toxicosis in fission yeast.

Bednor L et al. mBio 2023 Dec 22;:e0306223

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:34389684 - Genetic screen for suppression of transcriptional interference identifies a gain-of-function mutation in Pol2 termination factor Seb1.

Schwer B et al. Proc Natl Acad Sci U S A 2021 Aug 17;118(33)

PMID:21850271 - Genome-wide screening for genes associated with FK506 sensitivity in fission yeast.

Ma Y et al. PLoS One 2011;6(8):e23422

PMID:25117315 - A potential protective role for thiamine in glucose-driven oxidative stress.

Palabiyik B et al. Genet Mol Res 2014 Jul 25;13(3):5582-93

PMID:30212894 - Distinctive structural basis for DNA recognition by the fission yeast Zn2Cys6 transcription factor Pho7 and its role in phosphate homeostasis.

Garg A et al. Nucleic Acids Res 2018 Nov 30;46(21):11262-11273

PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.

Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101

PMID:30355770 - RNA polymerase II CTD interactome with 3' processing and termination factors in fission yeast and its impact on phosphate homeostasis.

Sanchez AM et al. Proc Natl Acad Sci U S A 2018 Nov 06;115(45):E10652-E10661

PMID:7961415 - Cloning, nucleotide sequence, and regulation of Schizosaccharomyces pombe thi4, a thiamine biosynthetic gene.

Zurlinden A et al. J Bacteriol 1994 Nov;176(21):6631-5

PMID:28410370 - A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.

Dudin O et al. PLoS Genet 2017 Apr;13(4):e1006721