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protein coding gene - oxa102 (SPBP4H10.03) - mitochondrial inner membrane insertase Oxa102

Gene summary

Standard name
oxa102
Systematic ID
SPBP4H10.03
Product
mitochondrial inner membrane insertase Oxa102
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
oxa1, oxa1-2, oxa1sp2, SPBC1346.02c
UniProt ID
O43092
ORFeome ID
32/32F10
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 2871716..2873493 forward strand

Annotation

Complementation

PBO:0011440 - functionally complements S. cerevisiae OXA1

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GO biological process

GO:0032979 - protein insertion into mitochondrial inner membrane from matrix

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GO cellular component

GO:0005743 - mitochondrial inner membrane

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GO:0005739 - mitochondrion

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GO molecular function

GO:0032977 - membrane insertase activity

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Multi-locus phenotype

FYPO:0000581 - decreased spore germination frequency

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Genotypes:

FYPO:0001355 - decreased vegetative cell population growth

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Genotypes:

Protein sequence feature

SO:0001808 - mitochondrial_targeting_signal

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SO:0001812 - transmembrane_helix

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Qualitative gene expression

PomGeneEx:0000012 - RNA level decreased

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PomGeneEx:0000014 - RNA present

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Quantitative gene expression

PBO:0006310 - protein level

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PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0003625 - abnormal microtubule cytoskeleton morphology during mitotic interphase

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Genotypes:

FYPO:0000121 - abnormal sporulation

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Genotypes:

FYPO:0003730 - abolished cell population growth on galactose carbon source

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Genotypes:

FYPO:0003690 - abolished cell population growth on glycerol/ethanol carbon source

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Genotypes:

FYPO:0000684 - decreased cell population growth on glycerol carbon source

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Genotypes:

FYPO:0001938 - decreased cytochrome-c oxidase activity

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Genotypes:

FYPO:0002009 - decreased oxygen consumption during vegetative growth

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Genotypes:

FYPO:0002111 - inviable tapered vegetative cell

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Genotypes:

FYPO:0000245 - loss of viability in stationary phase

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Genotypes:

FYPO:0001164 - normal growth on glucose carbon source

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Genotypes:

FYPO:0009070 - resistance to itraconazole

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Genotypes:

FYPO:0000725 - resistance to methyl methanesulfonate

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Genotypes:

FYPO:0000440 - sensitive to antimycin A

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Genotypes:

FYPO:0001245 - sensitive to cobalt

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Genotypes:

FYPO:0000104 - sensitive to cycloheximide

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Genotypes:

FYPO:0007931 - sensitive to egtazic acid

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Genotypes:

FYPO:0009088 - sensitive to magnesium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0001457 - sensitive to tunicamycin

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

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Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF0209660KD_IMPYidC/Oxa/ALB_CPFAM
cd200695TM_Oxa1-likeCDD
PTHR12428OXA1YidC/ALB3/OXA1/COX18PANTHER
mobidb-lite-Disorderdisorder_predictionMOBIDB-Disorder
mobidb-lite-Polardisorder_predictionMOBIDB-Polar

Orthologs

References / Literature

PMID:29259000 - Genes Important for Schizosaccharomyces pombe Meiosis Identified Through a Functional Genomics Screen.
Blyth J et al. Genetics 2018 Feb;208(2):589-603
PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.
Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160
PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.
Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:27918601 - Identifying genes required for respiratory growth of fission yeast.
Malecki M et al. Wellcome Open Res 2016;1:12
PMID:26098123 - Promoter nucleosome dynamics regulated by signalling through the CTD code.
Materne P et al. Elife 2015 Jun 22;4:e09008
PMID:10712694 - The respiratory gene OXA1 has two fission yeast orthologues which together encode a function essential for cellular viability.
Bonnefoy N et al. Mol Microbiol 2000 Mar;35(5):1135-45
PMID:25373780 - A genomic Multiprocess survey of machineries that control and link cell shape, microtubule organization, and cell-cycle progression.
Graml V et al. Dev Cell 2014 Oct 27;31(2):227-239
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:16911509 - The COX18 gene, involved in mitochondrial biogenesis, is functionally conserved and tightly regulated in humans and fission yeast.
Gaisne M et al. FEMS Yeast Res 2006 Sep;6(6):869-82
PMID:22806344 - Genome-wide screen reveals novel mechanisms for regulating cobalt uptake and detoxification in fission yeast.
Ryuko S et al. Mol Genet Genomics 2012 Aug;287(8):651-62
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12