protein coding gene - cut14 (SPBP4H10.06c) - condensin complex SMC subunit Smc2

Gene summary

Standard name

cut14

Systematic ID

SPBP4H10.06c

Product

condensin complex SMC subunit Smc2

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

smc2

UniProt ID

P41003

ORFeome ID

34/34A08

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome II: 2877687..2881368 reverse strand

Annotation

Protein features

Orthologs

• SMC2 (HGNC:14011) Homo sapiens
• cut14 (SJAG_03832) Schizosaccharomyces japonicus
• SMC2 (YFR031C) Saccharomyces cerevisiae

References / Literature

PMID:23263988 - Quantitative analysis of chromosome condensation in fission yeast.

Petrova B et al. Mol Cell Biol 2013 Mar;33(5):984-98

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:25764183 - Condensin HEAT subunits required for DNA repair, kinetochore/centromere function and ploidy maintenance in fission yeast.

Xu X et al. PLoS One 2015;10(3):e0119347

PMID:19454013 - Conserved features of cohesin binding along fission yeast chromosomes.

Schmidt CK et al. Genome Biol 2009;10(5):R52

PMID:18204818 - Identification of small molecules inducing apoptosis by cell-based assay using fission yeast deletion mutants.

Chung KS et al. Invest New Drugs 2008 Aug;26(4):299-307

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:22645654 - Opposing role of condensin hinge against replication protein A in mitosis and interphase through promoting DNA annealing.

Akai Y et al. Open Biol 2011 Dec;1(4):110023

PMID:25847133 - RNA pol II transcript abundance controls condensin accumulation at mitotically up-regulated and heat-shock-inducible genes in fission yeast.

Nakazawa N et al. Genes Cells 2015 Jun;20(6):481-99

PMID:28218250 - Chromatin remodeller Fun30 Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Lee J et al. Nat Commun 2017 Feb 20;8:14527

PMID:28882993 - The condensin complex is a mechanochemical motor that translocates along DNA.

Terakawa T et al. Science 2017 Nov 03;358(6363):672-676

PMID:31615333 - Condensin locates at transcriptional termination sites in mitosis, possibly releasing mitotic transcripts.

Nakazawa N et al. Open Biol 2019 Oct 31;9(10):190125

PMID:9285594 - DNA renaturation activity of the SMC complex implicated in chromosome condensation.

Sutani T et al. Nature 1997 Aug 21;388(6644):798-801

PMID:26204128 - Condensin targets and reduces unwound DNA structures associated with transcription in mitotic chromosome condensation.

Sutani T et al. Nat Commun 2015 Jul 23;6:7815

PMID:10485849 - Fission yeast condensin complex: essential roles of non-SMC subunits for condensation and Cdc2 phosphorylation of Cut3/SMC4.

Sutani T et al. Genes Dev 1999 Sep 01;13(17):2271-83

PMID:33153481 - Fission yeast condensin contributes to interphase chromatin organization and prevents transcription-coupled DNA damage.

Kakui Y et al. Genome Biol 2020 Nov 05;21(1):272

PMID:21540296 - Condensin phosphorylated by the Aurora-B-like kinase Ark1 is continuously required until telophase in a mode distinct from Top2.

Nakazawa N et al. J Cell Sci 2011 Jun 01;124(Pt 11):1795-807

PMID:27548313 - Transcription factors mediate condensin recruitment and global chromosomal organization in fission yeast.

Kim KD et al. Nat Genet 2016 Oct;48(10):1242-52

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:33434270 - Comparison of loop extrusion and diffusion capture as mitotic chromosome formation pathways in fission yeast.

Gerguri T et al. Nucleic Acids Res 2021 Feb 22;49(3):1294-1312

PMID:15507118 - An interactive gene network for securin-separase, condensin, cohesin, Dis1/Mtc1 and histones constructed by mass transformation.

Yuasa T et al. Genes Cells 2004 Nov;9(11):1069-82

PMID:18362178 - Dissection of the essential steps for condensin accumulation at kinetochores and rDNAs during fission yeast mitosis.

Nakazawa N et al. J Cell Biol 2008 Mar 24;180(6):1115-31

PMID:23084836 - Epigenetic regulation of condensin-mediated genome organization during the cell cycle and upon DNA damage through histone H3 lysine 56 acetylation.

Tanaka A et al. Mol Cell 2012 Nov 30;48(4):532-46

PMID:26404184 - High Confidence Fission Yeast SUMO Conjugates Identified by Tandem Denaturing Affinity Purification.

Nie M et al. Sci Rep 2015 Sep 25;5:14389

PMID:33468217 - Rbm10 facilitates heterochromatin assembly via the Clr6 HDAC complex.

Weigt M et al. Epigenetics Chromatin 2021 Jan 19;14(1):8

PMID:24362309 - A genetic screen for functional partners of condensin in fission yeast.

Robellet X et al. G3 (Bethesda) 2014 Feb 19;4(2):373-81

PMID:20709788 - Ccq1p and the condensin proteins Cut3p and Cut14p prevent telomere entanglements in the fission yeast Schizosaccharomyces pombe.

Motwani T et al. Eukaryot Cell 2010 Oct;9(10):1612-21

PMID:25520186 - ATPase-dependent auto-phosphorylation of the open condensin hinge diminishes DNA binding.

Akai Y et al. Open Biol 2014 Dec;4(12)

PMID:22540037 - Predicting the fission yeast protein interaction network.

Pancaldi V et al. G3 (Bethesda) 2012 Apr;2(4):453-67

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704

PMID:30914423 - Isolation of Fission Yeast Condensin Temperature-Sensitive Mutants with Single Amino Acid Substitutions Targeted to Hinge Domain.

Xu X et al. G3 (Bethesda) 2019 May 07;9(5):1777-1783

PMID:37820734 - Establishment of dsDNA-dsDNA interactions by the condensin complex.

Tang M et al. Mol Cell 2023 Nov 02;83(21):3787-3800.e9

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:7957061 - Fission yeast cut3 and cut14, members of a ubiquitous protein family, are required for chromosome condensation and segregation in mitosis.

Saka Y et al. EMBO J 1994 Oct 17;13(20):4938-52

PMID:8395535 - Identification of seven new cut genes involved in Schizosaccharomyces pombe mitosis.

Samejima I et al. J Cell Sci 1993 May;105 ( Pt 1):135-43

PMID:24945319 - CPF-associated phosphatase activity opposes condensin-mediated chromosome condensation.

Vanoosthuyse V et al. PLoS Genet 2014 Jun;10(6):e1004415

PMID:25392932 - RNA processing factors Swd2.2 and Sen1 antagonize RNA Pol III-dependent transcription and the localization of condensin at Pol III genes.

Legros P et al. PLoS Genet 2014 Nov;10(11):e1004794

PMID:26257282 - Interaction between TBP and Condensin Drives the Organization and Faithful Segregation of Mitotic Chromosomes.

Iwasaki O et al. Mol Cell 2015 Sep 03;59(5):755-67

PMID:15161942 - The nucleolus is involved in mRNA export from the nucleus in fission yeast.

Ideue T et al. J Cell Sci 2004 Jun 15;117(Pt 14):2887-95

PMID:9802907 - Dynamics of centromeres during metaphase-anaphase transition in fission yeast: Dis1 is implicated in force balance in metaphase bipolar spindle.

Nabeshima K et al. Mol Biol Cell 1998 Nov;9(11):3211-25

PMID:28825727 - Condensin-mediated remodeling of the mitotic chromatin landscape in fission yeast.

Kakui Y et al. Nat Genet 2017 Oct;49(10):1553-1557

PMID:11927555 - The fission yeast NIMA kinase Fin1p is required for spindle function and nuclear envelope integrity.

Krien MJ et al. EMBO J 2002 Apr 02;21(7):1713-22

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:26537787 - Targeting of SUMO substrates to a Cdc48-Ufd1-Npl4 segregase and STUbL pathway in fission yeast.

Køhler JB et al. Nat Commun 2015 Nov 05;6:8827

GO_REF:0000002 - Comments

PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.

Mata J et al. Nat Genet 2002 Sep;32(1):143-7

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:31072933 - Suppressor screening reveals common kleisin-hinge interaction in condensin and cohesin, but different modes of regulation.

Xu X et al. Proc Natl Acad Sci U S A 2019 May 28;116(22):10889-10898

PMID:12000964 - Cnd2 has dual roles in mitotic condensation and interphase.

Aono N et al. Nature 2002 May 09;417(6885):197-202