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protein coding gene - set6 (SPBP8B7.07c) - histone lysine methyltransferase Set6

Gene summary

Standard name
set6
Systematic ID
SPBP8B7.07c
Product
histone lysine methyltransferase Set6
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O94256
ORFeome ID
45/45D08
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome II: 3643793..3645539 reverse strand

Annotation

GO biological process

GO:0006338 - chromatin remodeling

References:

GO cellular component

GO:0000785 - chromatin

References:

GO:0005829 - cytosol

References:

GO:0005634 - nucleus

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GO molecular function

GO:0042054 - histone methyltransferase activity

References:

GO:0016279 - protein-lysine N-methyltransferase activity

References:

Modification

MOD:00046 - O-phospho-L-serine

References:

Multi-locus phenotype

FYPO:0003081 - decreased genetic imprinting at mating-type locus

References:

Genotypes:

Protein features

PBO:0111852 - SET domain

PBO:0111938 - zf-MYND type

PBO:0111743 - zinc finger protein

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0009098 - increased cell population growth on mannitol carbon source

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Genotypes:

FYPO:0004557 - increased vegetative cell population growth

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Genotypes:

FYPO:0006518 - loss of viability in G0

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Genotypes:

FYPO:0000245 - loss of viability in stationary phase

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Genotypes:

FYPO:0007553 - normal G1 to G0 transition

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Genotypes:

FYPO:0003082 - normal genetic imprinting at mating-type locus

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Genotypes:

FYPO:0000763 - resistance to cadmium

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Genotypes:

FYPO:0009038 - resistance to egtazic acid

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Genotypes:

FYPO:0009043 - resistance to potassium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0000830 - resistance to vanadate

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Genotypes:

FYPO:0009080 - sensitive to calcofluor and sodium dodecyl sulfate

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Genotypes:

FYPO:0001719 - sensitive to lithium

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

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Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

Protein features

IDNameInterPro nameDB name
PF00856SETSET_domPFAM
PF01753zf-MYNDZnf_MYNDPFAM
cd20071SET_SMYDCDD
PS01360ZF_MYND_1Znf_MYNDPROSITE_PATTERNS
PS50865ZF_MYND_2Znf_MYNDPROSITE_PROFILES
PS50280SETSET_domPROSITE_PROFILES
SM00317set_7SET_domSMART
SSF82199SET domainSET_dom_sfSUPERFAMILY
G3DSA:1.10.220.160GENE3D
G3DSA:6.10.140.2220GENE3D
G3DSA:2.170.270.10SET domainSET_dom_sfGENE3D
PTHR12197HISTONE-LYSINE N-METHYLTRANSFERASE SMYDH3K4_H4K5_MeTrfasePANTHER

Orthologs

References / Literature

PMID:23260662 - Lsd1 and lsd2 control programmed replication fork pauses and imprinting in fission yeast.
Holmes A et al. Cell Rep 2012 Dec 27;2(6):1513-20
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:33260998 - High-Throughput Flow Cytometry Combined with Genetic Analysis Brings New Insights into the Understanding of Chromatin Regulation of Cellular Quiescence.
Zahedi Y et al. Int J Mol Sci 2020 Nov 27;21(23)
GO_REF:0000051 - S. pombe keyword mapping
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.
Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.
Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:18818364 - Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast.
Roguev A et al. Science 2008 Oct 17;322(5900):405-10
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:15550243 - Methylation of histone H4 lysine 20 controls recruitment of Crb2 to sites of DNA damage.
Sanders SL et al. Cell 2004 Nov 24;119(5):603-14
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623