protein coding gene - SPBPB21E7.09 - L-asparaginase

Gene summary

Systematic ID: SPBPB21E7.09
Product: L-asparaginase
Organism: Schizosaccharomyces pombe (fission yeast)
Synonyms: SPAPB21E7.09
UniProt ID: Q8NKC0
ORFeome ID: 52/52A11
Characterisation status: biological role inferred
Feature type: mRNA gene
Genomic location: chromosome II: 76296..77625 forward strand

Annotation

PBO:0000106 - 3.5.1.1

GO biological process

GO:0006530 - L-asparagine catabolic process

References:

GO_REF:0000033

GO cellular component

GO:0009986 - cell surface

References:

GO_REF:0000051

GO:0042597 - periplasmic space

References:

GO_REF:0000033

GO molecular function

GO:0004067 - asparaginase activity

References:

GO_REF:0000033

Modification

MOD:00006 - N-glycosylated residue

References:

PMID:36408920

Protein sequence feature

SO:0000418 - signal_peptide

References:

PMID:36408920

Qualitative gene expression

PomGeneEx:0000018 - protein level increased

References:

PomGeneEx:0000027 - ribosomal density decreased

References:

PMID:29432178

PomGeneEx:0000011 - RNA level increased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PMID:23101633

PBO:0011963 - RNA level

References:

PMID:23101633

Single locus phenotype

FYPO:0001309 - increased viability in stationary phase

References:

PMID:34250083

Genotypes:

SPBPB21E7.09delta

FYPO:0002693 - resistance to diamide

References:

PMID:37787768

Genotypes:

SPBPB21E7.09delta

FYPO:0000830 - resistance to vanadate

References:

PMID:37787768

Genotypes:

SPBPB21E7.09delta

FYPO:0000096 - sensitive to cadmium

References:

PMID:37787768

Genotypes:

SPBPB21E7.09delta

FYPO:0001719 - sensitive to lithium

References:

PMID:37787768

Genotypes:

SPBPB21E7.09delta

FYPO:0009086 - sensitive to lithium chloride and sodium dodecyl sulfate

References:

PMID:37787768

Genotypes:

SPBPB21E7.09delta

FYPO:0007924 - sensitive to potassium chloride and sodium dodecyl sulfate

References:

PMID:37787768

Genotypes:

SPBPB21E7.09delta

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

SPBPB21E7.09delta

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

PMID:23697806

Genotypes:

SPBPB21E7.09delta

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

Protein features

ID	Name	InterPro name	DB name
PF17763	Asparaginase_C	Asparaginase_C	PFAM
PF00710	Asparaginase	L-asparaginase_N	PFAM
cd08964	L-asparaginase_II	AsnASE_II	CDD
PS51732	ASN_GLN_ASE_3	Asparaginase/glutaminase-like	PROSITE_PROFILES
SM00870	Asparaginase_2	Asparaginase/glutaminase-like	SMART
PR00139	ASNGLNASE	Asparaginase/glutaminase-like	PRINTS
G3DSA:3.40.50.40:FF:000006			FUNFAM
G3DSA:3.40.50.1170:FF:000001			FUNFAM
SSF53774	Glutaminase/Asparaginase	Asp/glu_Ase-like_sf	SUPERFAMILY
G3DSA:3.40.50.40		L-asparaginase_C	GENE3D
G3DSA:3.40.50.1170		L-asparaginase_N_sf	GENE3D
PTHR11707	L-ASPARAGINASE	Asparaginase/glutaminase-like	PANTHER
PIRSF500176	L_ASNase		PIRSF
PIRSF001220	L-ASNase_gatD	Asparaginase/glutaminase-like	PIRSF
TIGR00520	asnASE_II	AsnASE_II	NCBIFAM

Orthologs

ASPG (HGNC:20123) Homo sapiens
ASP3-1 (YLR155C) Saccharomyces cerevisiae
ASP3-2 (YLR157C) Saccharomyces cerevisiae
ASP3-3 (YLR158C) Saccharomyces cerevisiae
ASP3-4 (YLR160C) Saccharomyces cerevisiae

References / Literature

PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.: Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.: Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.: Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.: Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
GO_REF:0000051 - S. pombe keyword mapping
PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.: Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.: Skribbe M et al. Mol Cell 2025 Feb 19;
PMID:29432178 - General amino acid control in fission yeast is regulated by a nonconserved transcription factor, with functions analogous to Gcn4/Atf4.: Duncan CDS et al. Proc Natl Acad Sci U S A 2018 Feb 20;115(8):E1829-E1838
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.: Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.: Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.: Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.: Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.: UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
PMID:29214404 - The 19S proteasome regulates subtelomere silencing and facultative heterochromatin formation in fission yeast.: Seo HD et al. Curr Genet 2018 Jun;64(3):741-752